Plant Name: Achillea lycaonica
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.031E-13 | 4.914E-10 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2, NR1H4, PPARA, PPARD, PPARG, PTPN1, RORC |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 8.159E-10 | 1.184E-06 | ESR2, NR1H4, PPARA, PPARD, PPARG, RORC |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 2.588E-09 | 3.522E-06 | ESR2, NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 2.139E-07 | 1.664E-04 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 3.067E-07 | 2.303E-04 | ESR2, NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 1.040E-06 | 7.079E-04 | ESR2, NR1H4, PPARA, PPARD, PPARG, RORC |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.229E-27 | 2.676E-23 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 1.754E-06 | 1.061E-03 | ESR2, NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0065007; biological regulation | GO:0055088; lipid homeostasis | 3.478E-06 | 1.942E-03 | FABP3, FABP4, NPC1, NR1H4, PPARG |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 4.328E-06 | 2.207E-03 | NR1H4, PPARA, PPARD, PPARG, PTPN2 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 1.215E-05 | 4.812E-03 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.272E-05 | 4.860E-03 | AKR1B10, CYP1A2, HSD11B1, NPC1, NR1H4, PPARD |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.317E-05 | 4.860E-03 | CA2, CA7 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.317E-05 | 4.860E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 1.317E-05 | 4.860E-03 | GPBAR1, NR1H4 |
| BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 1.712E-05 | 6.112E-03 | CA2, CA9, CASP1, CASP7, CYP1A2, NPC1, PPARG, RORC, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 2.458E-05 | 8.195E-03 | FABP3, NR1H4, PPARG, TLR2 |
| BP | GO:0050896; response to stimulus | GO:0010243; response to organonitrogen compound | 2.484E-05 | 8.195E-03 | CASP1, CASP7, FABP3, NPC1, NR1H4, PPARA, PPARG, TLR2, TSHR |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 2.630E-05 | 8.245E-03 | PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0046320; regulation of fatty acid oxidation | 2.802E-05 | 8.595E-03 | FABP3, PPARA, PPARG |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 3.271E-05 | 9.371E-03 | ESR2, NPC1, NR1H4, RORC |
| BP | GO:0008152; metabolic process | GO:0006631; fatty acid metabolic process | 3.525E-05 | 9.716E-03 | CYP1A2, FAAH, FABP3, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 6.626E-21 | 7.214E-17 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.380E-19 | 7.513E-16 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 7.579E-27 | 5.760E-25 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 8.717E-11 | 3.312E-09 | FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 1.948E-04 | 4.935E-03 | CASP7; CASP1; TLR2 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 4.685E-04 | 8.902E-03 | PTPN1; ACP1; PTPRF |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 1.444E-03 | 1.829E-02 | PTPN1; PPARA; PTPRF |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.009E-03 | 1.534E-02 | CA2; CA4 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Melanoma | C43 | TERT; TLR2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Drug abuse | F10-F19 | PPARG |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9; TLR2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | TLR2 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1; PPARD |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| NA: NA | Dyslipidemia | NA | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | FAAH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | FAAH |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | FAAH |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; TLR2 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | FAAH |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PPARG |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | PPARG |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TLR2 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Prostate cancer | C61 | TERT; TLR2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1; HSD11B1 |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; GPBAR1; HSD11B1; PPARD; PPARG; PPARG |
| NA: NA | Edema | NA | CA2 |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PPARG |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Nicotine dependence | F17 | PPARG |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Radiation sickness | T66 | TLR2 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; HSD11B1; PPARD; PPARD; PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD; PPARG |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | FAAH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT; PPARG |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; CA4 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1; CA4; CA4 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD; PPARG |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT; TLR2 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | FAAH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSD11B1; HSD11B1; PPARG |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PPARG; PPARG |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; TERT |