Plant Name: Achillea lycaonica
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 2.139E-07 | 1.664E-04 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 3.067E-07 | 2.303E-04 | ESR2, NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 1.040E-06 | 7.079E-04 | ESR2, NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 1.754E-06 | 1.061E-03 | ESR2, NR1H4, PPARA, PPARD, PPARG, RORC |
| BP | GO:0065007; biological regulation | GO:0055088; lipid homeostasis | 3.478E-06 | 1.942E-03 | FABP3, FABP4, NPC1, NR1H4, PPARG |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 4.328E-06 | 2.207E-03 | NR1H4, PPARA, PPARD, PPARG, PTPN2 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 1.215E-05 | 4.812E-03 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.272E-05 | 4.860E-03 | AKR1B10, CYP1A2, HSD11B1, NPC1, NR1H4, PPARD |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.317E-05 | 4.860E-03 | CA2, CA7 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.317E-05 | 4.860E-03 | GPBAR1, NR1H4 |
Showing 1 to 10 of 24 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 7.579E-27 | 5.760E-25 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 8.717E-11 | 3.312E-09 | FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 4.685E-04 | 8.902E-03 | PTPN1; ACP1; PTPRF |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 1.444E-03 | 1.829E-02 | PTPN1; PPARA; PTPRF |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.009E-03 | 1.534E-02 | CA2; CA4 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 1.948E-04 | 4.935E-03 | CASP7; CASP1; TLR2 |
Showing 1 to 6 of 6 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| C00-D49: Neoplasms | Melanoma | C43 | TERT; TLR2 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9; TLR2 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | FAAH |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; TLR2 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT |
Showing 1 to 10 of 66 entries