CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; OPRD1;
Small molecule receptor (family A GPCR)	DRD3; HTR2C; GPBAR1;
Protein Phosphatase	PTPN1; ACP1; PTPRF; PTPN2;
Enzyme_unclassified	RECQL; HSD11B1; AKR1B10;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Aspartic protease	BACE1;
SLC superfamily of solute carriers	SLC22A8; SLC22A6;
Endoplasmic reticular retrotranslocon family	VCP;
Unclassified	MCL1; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Endoplasmic reticular retrotranslocon family	VCP	Transitional endoplasmic reticulum ATPase	P55072	CHEMBL1075145
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335

Showing 1 to 10 of 20 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	2.953E-06	1.811E-02	ACP1, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	3.054E-06	1.811E-02	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	6.104E-06	2.658E-02	PTPN1, PTPN2
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	3.054E-06	1.811E-02	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004725; protein tyrosine phosphatase activity	3.327E-06	1.811E-02	ACP1, PTPN1, PTPN2, PTPRF

Showing 1 to 5 of 5 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.959E-02	1.167E-01	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.153E-02	1.167E-01	AKR1B10
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.465E-04	2.709E-03	OPRD1, HTR2C, DRD3, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	1.073E-02	5.673E-02	PTPN2, MCL1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	5.298E-05	1.960E-03	PTPN1, ACP1, PTPRF
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	8.511E-03	5.248E-02	LMNA, MCL1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.265E-03	2.794E-02	NR1H4, SLC22A8
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	8.394E-03	5.248E-02	PTPN1, PTPRF
09150 Organismal Systems	09159 Environmental adaptation	hsa04710	Circadian rhythm	2.959E-02	1.167E-01	RORC
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	5.245E-03	4.851E-02	PTPN1, PTPRF

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRD1;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1;

Showing 1 to 10 of 16 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Phyllosma capensis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities