Plant Name: Ficus simplicissima
Taxonomic Information:
Plant ID: NPO15147
Plant Latin Name: Ficus simplicissima
Taxonomy Genus: Ficus
Taxonomy Family: Moraceae
Plant External Links:
NCBI TaxonomyDB:
1822162
Plant-of-the-World-Online:
853709-1
Used in Medicines:
Country/Region:
ChinaTraditional Medicine System:
TCMGeographical Distribution:
Nepal; Bangladesh; Myanmar; Indonesia; India; Cambodia; Vietnam; China; Laos; Thailand
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| DRD3; | |
| ALPL; | |
| SRC; IGF1R; PTK2; AXL; MAPK1; ALK; KDR; | |
| CA2; CA14; | |
| NFKB1; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2A6; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
| Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Protein Kinase | PTK2 | Focal adhesion kinase 1 | Q05397 | CHEMBL2695 |
| Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | ALK | ALK tyrosine kinase receptor | Q9UM73 | CHEMBL4247 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Small molecule receptor (family A GPCR) | DRD3 | Dopamine D3 receptor | P35462 | CHEMBL234 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 3.025E-08 | 1.098E-04 | IGF1R, KDR, PTK2, SRC |
| MF | GO:0060089; molecular transducer activity | GO:0004714; transmembrane receptor protein tyrosine kinase activity | 9.401E-08 | 2.559E-04 | ALK, AXL, IGF1R, KDR |
| BP | GO:0009987; cellular process | GO:0048010; vascular endothelial growth factor receptor signaling pathway | 1.727E-07 | 3.133E-04 | AXL, KDR, PTK2, SRC |
| BP | GO:0009987; cellular process | GO:0035690; cellular response to drug | 1.151E-06 | 9.279E-04 | AXL, KDR, MAPK1, NFKB1, SRC |
| BP | GO:0022610; biological adhesion | GO:0051893; regulation of focal adhesion assembly | 7.356E-06 | 3.601E-03 | KDR, PTK2, SRC |
| BP | GO:0040011; locomotion | GO:0030335; positive regulation of cell migration | 1.035E-05 | 4.421E-03 | IGF1R, KDR, MAPK1, PTK2, SRC |
| BP | Unclassified; | GO:2000021; regulation of ion homeostasis | 1.202E-05 | 4.901E-03 | CA2, DRD3, KDR, SRC |
| BP | GO:0050896; response to stimulus | GO:0010035; response to inorganic substance | 1.283E-05 | 4.901E-03 | AXL, CA2, KDR, MAPK1, SRC |
| BP | GO:0009987; cellular process | GO:0060159; regulation of dopamine receptor signaling pathway | 2.188E-05 | 7.111E-03 | ALK, DRD3 |
| BP | GO:0009987; cellular process | GO:0038127; ERBB signaling pathway | 2.691E-05 | 8.254E-03 | MAPK1, PTK2, SRC |
| BP | GO:0050896; response to stimulus | GO:0038166; angiotensin-activated signaling pathway | 3.206E-05 | 9.564E-03 | CA2, SRC |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 3.201E-05 | 9.564E-03 | ALK, AXL, IGF1R, KDR, MAPK1, PTK2, SRC |
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 7.661E-08 | 8.449E-06 | SRC, KDR, MAPK1, PTK2 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 1.906E-07 | 8.449E-06 | SRC, KDR, MAPK1, PTK2, IGF1R |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 1.860E-07 | 8.449E-06 | SRC, KDR, MAPK1, PTK2, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 2.469E-06 | 8.208E-05 | KDR, MAPK1, PTK2, NFKB1, IGF1R |
| 09150 Organismal Systems | 09151 Immune system | hsa04062 | Chemokine signaling pathway | 6.885E-06 | 1.831E-04 | SRC, MAPK1, NFKB1, PTK2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 1.109E-05 | 2.209E-04 | SRC, KDR, MAPK1, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 1.480E-05 | 2.286E-04 | KDR, MAPK1, NFKB1, IGF1R |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 1.583E-05 | 2.286E-04 | SRC, MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 1.163E-05 | 2.209E-04 | SRC, MAPK1, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 2.993E-05 | 3.317E-04 | MAPK1, NFKB1, IGF1R |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 1.719E-05 | 2.286E-04 | SRC, MAPK1, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04012 | ErbB signaling pathway | 2.795E-05 | 3.317E-04 | SRC, MAPK1, PTK2 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.307E-04 | 1.023E-03 | MAPK1, NFKB1, PTK2, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 4.633E-05 | 4.740E-04 | MAPK1, NFKB1, IGF1R |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 1.155E-04 | 1.023E-03 | LMNA, MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 1.308E-04 | 1.023E-03 | SRC, MAPK1, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 3.554E-04 | 2.327E-03 | SRC, MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05152 | Tuberculosis | 2.347E-04 | 1.698E-03 | SRC, MAPK1, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 2.426E-04 | 1.698E-03 | NFKB1, PTK2, IGF1R |
| 09140 Cellular Processes | 09142 Cell motility | hsa04810 | Regulation of actin cytoskeleton | 4.030E-04 | 2.437E-03 | SRC, MAPK1, PTK2 |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04144 | Endocytosis | 7.030E-04 | 3.634E-03 | SRC, KDR, IGF1R |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 6.858E-04 | 3.634E-03 | ALK, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 7.104E-04 | 3.634E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 9.229E-04 | 4.363E-03 | MAPK1, IGF1R |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 3.673E-04 | 2.327E-03 | SRC, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04730 | Long-term depression | 7.869E-04 | 3.876E-03 | MAPK1, IGF1R |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 9.514E-04 | 4.363E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 1.100E-03 | 4.547E-03 | MAPK1, IGF1R |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.010E-03 | 4.476E-03 | SRC, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 1.162E-03 | 4.547E-03 | MAPK1, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 1.162E-03 | 4.547E-03 | MAPK1, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 7.104E-04 | 3.634E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 1.162E-03 | 4.547E-03 | MAPK1, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 1.798E-03 | 5.979E-03 | SRC, MAPK1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.209E-03 | 6.528E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.608E-03 | 5.629E-03 | NFKB1, PTK2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 2.081E-03 | 6.528E-03 | MAPK1, IGF1R |
| 09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 1.917E-03 | 6.219E-03 | NFKB1, IGF1R |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05100 | Bacterial invasion of epithelial cells | 1.326E-03 | 4.897E-03 | SRC, PTK2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 2.123E-03 | 6.528E-03 | SRC, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 1.226E-03 | 4.660E-03 | MAPK1, NFKB1 |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04540 | Gap junction | 1.683E-03 | 5.739E-03 | SRC, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05146 | Amoebiasis | 2.166E-03 | 6.528E-03 | NFKB1, PTK2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 1.608E-03 | 5.629E-03 | MAPK1, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 2.429E-03 | 6.731E-03 | MAPK1, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 2.613E-03 | 7.091E-03 | MAPK1, NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 2.340E-03 | 6.621E-03 | MAPK1, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04660 | T cell receptor signaling pathway | 2.340E-03 | 6.621E-03 | MAPK1, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 2.999E-03 | 7.777E-03 | SRC, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 2.999E-03 | 7.777E-03 | MAPK1, NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04611 | Platelet activation | 3.201E-03 | 7.866E-03 | SRC, MAPK1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 3.099E-03 | 7.777E-03 | MAPK1, NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 3.099E-03 | 7.777E-03 | MAPK1, NFKB1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04114 | Oocyte meiosis | 3.253E-03 | 7.866E-03 | MAPK1, IGF1R |
| 09150 Organismal Systems | 09158 Development | hsa04380 | Osteoclast differentiation | 3.735E-03 | 8.402E-03 | MAPK1, NFKB1 |
| 09150 Organismal Systems | 09158 Development | hsa04360 | Axon guidance | 3.463E-03 | 8.156E-03 | MAPK1, PTK2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 3.790E-03 | 8.402E-03 | MAPK1, IGF1R |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 4.307E-03 | 9.391E-03 | MAPK1, IGF1R |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 3.790E-03 | 8.402E-03 | MAPK1, NFKB1 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 6.151E-05 | 5.844E-04 | CA2, CA14 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 3.495E-03 | 8.156E-03 | CYP2A6 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Renal cancer | C64 | KDR; |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | KDR; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR; |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR; |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
| C00-D49: Neoplasms | AML | NA | KDR; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | IGF1R; KDR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | PTK2; IGF1R; KDR; MAPK1; SRC; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | IGF1R; |
| G00-G99: Diseases of the nervous system G00-G99 | Motor neurone disease | G12.2 | IGF1R; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | IGF1R; SRC; |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR; |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | KDR; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Emesis | R11 | DRD3; |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
| NA: NA | Edema | NA | CA2; |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
| K00-K95: Diseases of the digestive system | Gastric motility disorder | K22.4 | DRD3; |
| H00-H59: Diseases of the eye and adnexa | Graves' ophthalmopathy | H06.2 | IGF1R; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Growth failure | R62.8 | IGF1R; |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR; |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR; |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | KDR; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | PTK2; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | DRD3; |
| C00-D49: Neoplasms | Breast cancer | C50 | IGF1R; KDR; |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR; |
| C00-D49: Neoplasms | Mesothelioma | C45 | PTK2; |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | SRC; |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR; |
| C00-D49: Neoplasms | Metastasis | C00-C97 | AXL; |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR; |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | IGF1R; |
| C00-D49: Neoplasms | Cancer | C00-C96 | PTK2; IGF1R; KDR; NFKB1; MAPK1; SRC; |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | SRC; |
| C00-D49: Neoplasms | Glioma | C71 | KDR; |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | SRC; |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | KDR; |
| C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Male sexual disorders | F52 | DRD3; |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | SRC; |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; |
| C00-D49: Neoplasms | Liver cancer | C22 | IGF1R; KDR; |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | IGF1R; KDR; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | SRC; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | SRC; |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | SRC; |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | SRC; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Drug abuse | F10-F19 | DRD3; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | IGF1R; KDR; AXL; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | KDR; |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | KDR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cocaine addiction | F14.2 | DRD3; |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR; |
| C00-D49: Neoplasms | Melanoma | C43 | KDR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD3; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic disorder | L40 | IGF1R; |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Female sexual dysfunction | F52 | DRD3; |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | KDR; |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR; |
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
