Plant ID: NPO15108
Plant Latin Name: Angiopteris evecta
Taxonomy Genus: Angiopteris
Taxonomy Family: Marattiaceae
NCBI TaxonomyDB:
13825
Plant-of-the-World-Online:
n.a.
Thailand; India
GPBAR1; | |
PTPN1; PTPN2; ACP1; PTPRF; | |
RECQL; HSD11B1; AKR1B10; | |
MAPK1; PRKCA; | |
CA2; CA1; CA12; CA9; CA5B; CA3; CA14; CA7; CA5A; CA6; | |
RORC; | |
NR1H4; | |
MMP12; MMP2; | |
HTT; LMNA; | |
L3MBTL1; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
Metallo protease | MMP12 | Matrix metalloproteinase 12 | P39900 | CHEMBL4393 |
Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
Protein Kinase | PRKCA | Protein kinase C alpha | P17252 | CHEMBL299 |
Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
Protein Phosphatase | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | P24666 | CHEMBL4903 |
Protein Phosphatase | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | P10586 | CHEMBL3521 |
Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.269E-26 | 2.764E-22 | CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 5.640E-06 | 6.464E-03 | CA2, CA7 |
BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 5.640E-06 | 6.464E-03 | GPBAR1, NR1H4 |
MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 5.640E-06 | 6.464E-03 | GPBAR1, NR1H4 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.025E-20 | 1.116E-16 | CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.189E-19 | 2.281E-15 | CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
MF | GO:0005488; binding | GO:0008270; zinc ion binding | 7.094E-16 | 2.574E-12 | CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, L3MBTL1, MMP12, MMP2, NR1H4, PRKCA, PTPN1, RORC |
BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 1.041E-05 | 1.063E-02 | ACP1, PTPN1, PTPN2, PTPRF |
MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 2.813E-05 | 2.356E-02 | CA1, CA2 |
MF | GO:0003824; catalytic activity | GO:0016791; phosphatase activity | 3.343E-05 | 2.696E-02 | ACP1, CA3, PTPN1, PTPN2, PTPRF |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 5.796E-26 | 7.419E-24 | CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14 |
09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 2.841E-06 | 1.818E-04 | PTPN1, MAPK1, ACP1, PTPRF |
09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.348E-04 | 1.071E-02 | MMP2, MAPK1, PRKCA |
09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 2.463E-04 | 1.051E-02 | MMP2, MAPK1, PRKCA |
09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 8.504E-04 | 2.177E-02 | PTPN1, MAPK1, PTPRF |
09150 Organismal Systems | 09155 Excretory system | hsa04960 | Aldosterone-regulated sodium reabsorption | 1.261E-03 | 2.548E-02 | MAPK1, PRKCA |
09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 1.393E-03 | 2.548E-02 | MMP2, MAPK1 |
09150 Organismal Systems | 09156 Nervous system | hsa04730 | Long-term depression | 2.960E-03 | 3.229E-02 | MAPK1, PRKCA |
09150 Organismal Systems | 09151 Immune system | hsa04664 | Fc epsilon RI signaling pathway | 3.784E-03 | 3.229E-02 | MAPK1, PRKCA |
09150 Organismal Systems | 09156 Nervous system | hsa04720 | Long-term potentiation | 3.569E-03 | 3.229E-02 | MAPK1, PRKCA |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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