Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC100998 PRKCA 1 19000 IC50 PMID: 9834166
NPC113733 POLB 2 Median: 51840
Range: 43400 to 60280
IC50 PMID: 14640519
PMID: 18343122
NPC13067 CYP3A4 2 Median: 39810.7
Range: 39810.7 to 39810.7
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC13067 CASP7 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC13067 KDM4E 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC13067 CASP1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC13067 ALDH1A1 1 22387.2 Potency PubChem BioAssay data set
CHEMBL1201862
NPC13067 HPGD 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC139891 TDP1 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC197316 L3MBTL1 1 15848.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC230301 DPP4 1 28840 IC50 DOI: 10.1039/C0MD00245C
NPC230301 POLB 1 26300 IC50 PMID: 14640519
NPC26960 PTPN1 1 32600 IC50 PMID: 25497963
NPC287597 CYP19A1 1 35300 IC50 PMID: 21261296
NPC51700 PPARA 1 41310 EC50 PMID: 21855333
NPC51700 AKR1B1 1 41000 IC50 PMID: 21561086
NPC51700 CYP19A1 1 32000 IC50 PMID: 18192087
NPC51700 PTPN6 1 25780 IC50 PMID: 18707891
NPC51700 POLB 1 18600 IC50 PMID: 15165161
NPC51700 CTSD 1 18200 IC50 DOI: 10.1007/s00044-012-0397-z
NPC51700 SLCO1B1 1 15848.93 IC50 PMID: 23571415
NPC64141 MMP9 1 14280 IC50 PMID: 22658537
NPC78326 ABCG2 1 17200 IC50 PMID: 21275386
NPC18335 XDH 1 10890 IC50 PMID: 17379526
NPC29883 CA2 2 Median: 10600
Range: 10600 to 10600
Ki PMID: 18501600
PMID: 18579385
NPC51700 SLCO1B3 1 11481.54 IC50 PMID: 23571415
NPC64141 MMP13 1 11090 IC50 PMID: 22658537