CMAUP Plant Collective Molecular Activities

Plant Name: Rhus chinensis

Taxonomic Information:

Plant ID: NPO14827
Plant Latin Name: Rhus chinensis
Taxonomy Genus: Rhus
Taxonomy Family: Anacardiaceae

Plant External Links:

NCBI TaxonomyDB: 289753
Plant-of-the-World-Online: 70452-1

Used in Medicines:

Country/Region:

Thailand; China; India

Traditional Medicine System:

Indian Folk; TCM; Siddha

Medicinal Functions:

Anthelmintic; Antiphlogistic; Antiseptic; Astringent; Cholagogue; Depurative; Haemostatic

Geographical Distribution:

Bangladesh; South Africa; Nepal; India; China; Thailand; Japan; Taiwan

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1; ADRA2C;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	TDP1; HPGD; GFER; NOX4; ALDH1A1; POLB;
Transferase	POLA1; FUT7;
Lyase	CA2; CA1; CA12; CA9; CA14; CA5B; CA3; CA7; CA5A; CA4; CA6;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Lysine demethylase	KDM4E;
Unclassified	LMNA; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Transferase	POLA1	DNA polymerase alpha subunit	P09884	CHEMBL1828
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.646E-09	1.665E-05	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.374E-30	1.824E-25	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.074E-06	8.266E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	6.074E-06	8.266E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	6.074E-06	8.266E-03	GPBAR1, NR1H4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.596E-23	5.004E-19	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.641E-21	7.148E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.029E-05	3.471E-02	CA1, CA2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.170E-29	1.344E-27	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4.696E-04	6.104E-03	CA2, CA4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.425E-03	3.835E-02	CA2, NR1H4
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	2.401E-02	1.422E-01	SMN2, SMN1
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	3.714E-02	1.422E-01	CA2
09120 Genetic Information Processing	09124 Replication and repair	hsa03030	DNA replication	4.923E-02	1.422E-01	POLA1
09100 Metabolism	09107 Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3.579E-02	1.422E-01	FUT7
09100 Metabolism	09107 Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4.253E-02	1.422E-01	FUT7
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	4.522E-02	1.422E-01	POLB
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	9.865E-02	2.137E-01	LMNA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Viral infections	B01, B02, A60, B00, B27, G05.1, P35.2	POLA1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases