CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.646E-09	1.665E-05	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.374E-30	1.824E-25	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.074E-06	8.266E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	6.074E-06	8.266E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	6.074E-06	8.266E-03	GPBAR1, NR1H4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.596E-23	5.004E-19	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.641E-21	7.148E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	5.170E-29	1.344E-27	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	4.696E-04	6.104E-03	CA2; CA4
hsa04976	Bile secretion_Homo sapiens_hsa04976	4.425E-03	3.835E-02	CA2; NR1H4

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
C00-D49: Neoplasms	Breast cancer	C50	CA9
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; MAPT
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
NA: NA	Edema	NA	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C; NPSR1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C; CA4; CA4
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Viral infections	B01, B02, A60, B00, B27, G05.1, P35.2	POLA1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	GPBAR1
C00-D49: Neoplasms	Renal cancer	C64	CA9
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Rhus chinensis

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases