CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Voltage-gated sodium channel	SCN3A; SCN2A; SCN1A; SCN11A; SCN8A; SCN4A; SCN9A;
Unclassified	HTT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Voltage-gated sodium channel	SCN3A	Sodium channel protein type III alpha subunit	Q9NY46	CHEMBL5163
Voltage-gated sodium channel	SCN2A	Sodium channel protein type II alpha subunit	Q99250	CHEMBL4187
Voltage-gated sodium channel	SCN1A	Sodium channel protein type I alpha subunit	P35498	CHEMBL1845
Voltage-gated sodium channel	SCN11A	Sodium channel protein type XI alpha subunit	Q9UI33	CHEMBL5167
Voltage-gated sodium channel	SCN8A	Sodium channel protein type VIII alpha subunit	Q9UQD0	CHEMBL5202
Voltage-gated sodium channel	SCN4A	Sodium channel protein type IV alpha subunit	P35499	CHEMBL2072
Voltage-gated sodium channel	SCN9A	Sodium channel protein type IX alpha subunit	Q15858	CHEMBL4296

Showing 1 to 8 of 8 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0019228; neuronal action potential	8.182E-20	4.454E-16	SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A
BP	GO:0065007; biological regulation	GO:0086010; membrane depolarization during action potential	1.084E-18	4.719E-15	SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A
BP	GO:0051179; localization	GO:0035725; sodium ion transmembrane transport	6.890E-16	1.667E-12	SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A
BP	GO:0051179; localization	GO:0034765; regulation of ion transmembrane transport	5.246E-14	9.520E-11	HTT, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A
CC	GO:0044464; cell part	GO:0033268; node of Ranvier	2.117E-08	1.002E-05	SCN1A, SCN2A, SCN8A
CC	GO:0044464; cell part	GO:0043194; axon initial segment	9.886E-06	3.986E-03	SCN1A, SCN8A
CC	GO:0044425; membrane part	GO:0001518; voltage-gated sodium channel complex	1.380E-22	3.006E-18	SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A
MF	GO:0005215; transporter activity	GO:0005244; voltage-gated ion channel activity	8.790E-14	1.276E-10	SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A
MF	GO:0005215; transporter activity	GO:0008381; mechanosensitive ion channel activity	3.351E-12	3.041E-09	SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A
MF	GO:0005215; transporter activity	GO:0005248; voltage-gated sodium channel activity	9.856E-21	7.154E-17	SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A

Showing 1 to 10 of 10 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09157 Sensory system	hsa04742	Taste transduction	3.802E-06	1.141E-05	SCN9A, SCN2A, SCN3A
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	5.046E-02	7.465E-02	SCN1A
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05016	Huntington's disease	7.465E-02	7.465E-02	HTT

Showing 1 to 3 of 3 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Infections with sarcoptes scabiei	B86	SCN1A;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	SCN1A;
C00-D49: Neoplasms	Gastric cancer	C16	SCN1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	SCN1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	SCN1A;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	SCN1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	SCN1A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	SCN1A;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	SCN1A;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	SCN1A;

Showing 1 to 10 of 35 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Neopicrorhiza scrophulariiflora

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities