Plant Name: Neopicrorhiza scrophulariiflora
Taxonomic Information:
Plant ID: NPO14720
Plant Latin Name: Neopicrorhiza scrophulariiflora
Taxonomy Genus: Neopicrorhiza
Taxonomy Family: Plantaginaceae
Plant External Links:
NCBI TaxonomyDB:
470706
Plant-of-the-World-Online:
914299-1
Used in Medicines:
Unknown.
Geographical Distribution:
Nepal; China
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| SCN3A; SCN2A; SCN1A; SCN11A; SCN8A; SCN4A; SCN9A; | |
| HTT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Voltage-gated sodium channel | SCN3A | Sodium channel protein type III alpha subunit | Q9NY46 | CHEMBL5163 |
| Voltage-gated sodium channel | SCN2A | Sodium channel protein type II alpha subunit | Q99250 | CHEMBL4187 |
| Voltage-gated sodium channel | SCN1A | Sodium channel protein type I alpha subunit | P35498 | CHEMBL1845 |
| Voltage-gated sodium channel | SCN11A | Sodium channel protein type XI alpha subunit | Q9UI33 | CHEMBL5167 |
| Voltage-gated sodium channel | SCN8A | Sodium channel protein type VIII alpha subunit | Q9UQD0 | CHEMBL5202 |
| Voltage-gated sodium channel | SCN4A | Sodium channel protein type IV alpha subunit | P35499 | CHEMBL2072 |
| Voltage-gated sodium channel | SCN9A | Sodium channel protein type IX alpha subunit | Q15858 | CHEMBL4296 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005215; transporter activity | GO:0005244; voltage-gated ion channel activity | 8.790E-14 | 1.276E-10 | SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A |
| MF | GO:0005215; transporter activity | GO:0008381; mechanosensitive ion channel activity | 3.351E-12 | 3.041E-09 | SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A |
| CC | GO:0044464; cell part | GO:0033268; node of Ranvier | 2.117E-08 | 1.002E-05 | SCN1A, SCN2A, SCN8A |
| CC | GO:0044464; cell part | GO:0043194; axon initial segment | 9.886E-06 | 3.986E-03 | SCN1A, SCN8A |
| CC | GO:0044425; membrane part | GO:0001518; voltage-gated sodium channel complex | 1.380E-22 | 3.006E-18 | SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A |
| MF | GO:0005215; transporter activity | GO:0005248; voltage-gated sodium channel activity | 9.856E-21 | 7.154E-17 | SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A |
| BP | GO:0009987; cellular process | GO:0019228; neuronal action potential | 8.182E-20 | 4.454E-16 | SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A |
| BP | GO:0065007; biological regulation | GO:0086010; membrane depolarization during action potential | 1.084E-18 | 4.719E-15 | SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A |
| BP | GO:0051179; localization | GO:0035725; sodium ion transmembrane transport | 6.890E-16 | 1.667E-12 | SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A |
| BP | GO:0051179; localization | GO:0034765; regulation of ion transmembrane transport | 5.246E-14 | 9.520E-11 | HTT, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN8A, SCN9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09157 Sensory system | hsa04742 | Taste transduction | 3.802E-06 | 1.141E-05 | SCN9A, SCN2A, SCN3A |
| 09150 Organismal Systems | 09156 Nervous system | hsa04728 | Dopaminergic synapse | 5.046E-02 | 7.465E-02 | SCN1A |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 7.465E-02 | 7.465E-02 | HTT |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | SCN1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | SCN1A; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | SCN1A; |
| I00-I99: Diseases of the circulatory system | Cerebral infarction | I63 | SCN1A; |
| I00-I99: Diseases of the circulatory system | Heart arrhythmia | I47-I49 | SCN1A; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cough | R05 | SCN1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Bipolar disorder | F31, F40-F42 | SCN1A; |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | SCN1A; |
| I00-I99: Diseases of the circulatory system | Cardiac failure | I50 | SCN1A; |
| I00-I99: Diseases of the circulatory system | Cardiac arrhythmias | I47-I49 | SCN1A; |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | SCN1A; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Local or regional analgesia and anesthesia | R20.0 | SCN1A; |
| C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | SCN1A; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Chronic pain | R52.1-R52.2, G89 | SCN9A; |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | SCN1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | SCN1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | SCN9A; SCN4A; SCN1A; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Cystic fibrosis | E84 | SCN1A; |
| C00-D49: Neoplasms | Gastric cancer | C16 | SCN1A; |
| NA: NA | Seizure disorder | NA | SCN1A; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | SCN1A; |
| O00-O9A: Pregnancy, childbirth and the puerperium | Oxytocic | O00-O99 | SCN1A; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Nervous and musculoskeletal disorders | R25-R29 | SCN4A; |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | SCN1A; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | SCN1A; |
| A00-B99: Certain infectious and parasitic diseases | Infections with sarcoptes scabiei | B86 | SCN1A; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | SCN1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Seizures occurring during or following neurosurgery | G40 | SCN1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Seizures | G40, P90, R56 | SCN1A; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Seizures associated with lennox-Gastaut syndrome | R56.9 | SCN1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Peripheral neuropathy | G64 | SCN1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | SCN1A; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | SCN1A; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Spasm | R25.2 | SCN1A; |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | SCN1A; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
