CMAUP Plant Collective Molecular Activities

Plant Name: Hypericum hirsutum

Taxonomic Information:

Plant ID: NPO14367
Plant Latin Name: Hypericum hirsutum
Taxonomy Genus: Hypericum
Taxonomy Family: Hypericaceae

Plant External Links:

NCBI TaxonomyDB: 673928
Plant-of-the-World-Online: 433492-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Canada; Turkey; Italy; France; Ireland; Norway; Belarus; Iran; Algeria; China; Belgium; Germany; Kazakhstan; Spain; Ukraine; Netherlands; Denmark; Poland; Finland; Sweden; Switzerland; Russia; Bulgaria; Romania; Albania; United Kingdom; Austria; Greece

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	RECQL; TDP1; GLO1; GFER; APEX1; POLB;
Hydrolase	ACHE;
Isomerase	TOP2A;
Protein Kinase	AURKA; KDR; CDK8; AURKB;
Lyase	CA2; CA12; CA14; CA7; CA4;
Transcription Factor	HIF1A;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Isomerase	TOP2A	DNA topoisomerase II alpha	P11388	CHEMBL1806
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.477E-12	4.874E-08	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.192E-10	1.738E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.583E-09	6.894E-06	CA12, CA14, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	9.018E-09	2.182E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.771E-08	1.910E-04	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.203E-07	3.998E-04	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	7.528E-07	1.093E-03	APEX1, CA2, CYP1A1, CYP1A2, CYP1B1, HIF1A, KDR
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	1.356E-06	1.697E-03	APEX1, POLB
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.571E-06	2.666E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.571E-06	2.666E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.066E-06	3.405E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0007346; regulation of mitotic cell cycle	8.006E-06	4.782E-03	APEX1, AURKA, AURKB, CDK8, CYP1A1, L3MBTL1, TOP2A
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	8.126E-06	4.782E-03	CYP1A1, CYP1A2
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	1.353E-05	7.016E-03	AURKA, AURKB
MF	GO:0005488; binding	GO:0020037; heme binding	1.477E-05	7.482E-03	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0032787; monocarboxylic acid metabolic process	1.589E-05	7.864E-03	CYP1A1, CYP1A2, CYP1B1, CYP2C19, GLO1, HIF1A
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.028E-05	9.398E-03	CYP1A2, CYP2C19
MF	GO:0003824; catalytic activity	GO:0035174; histone serine kinase activity	2.028E-05	9.398E-03	AURKA, AURKB

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.742E-12	3.174E-10	CA12, CA2, CA4, CA7, CA14
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.190E-06	4.490E-05	CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.277E-05	1.745E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.933E-05	4.032E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.840E-05	6.429E-04	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.499E-03	6.827E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.154E-04	2.155E-03	CA2, CA4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.040E-04	2.952E-03	CYP1A2, CYP2C19
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	6.536E-04	3.350E-03	POLB, APEX1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; KDR; ACHE; HIF1A;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKA; AURKB;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
C00-D49: Neoplasms	Solid tumours	C00-D48	TOP2A; AURKA; AURKB; KDR; HIF1A;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Breast cancer	C50	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Glioma	C71	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
NA: NA	Upper abdominal bloating	NA	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA;
C00-D49: Neoplasms	Liver cancer	C22	KDR;
C00-D49: Neoplasms	AML	NA	KDR;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases