Putative targets based on weak experimental activity

Plant ingredients against the target with activities between 10uM and 50uM


Ingredient ID Target (Gene Symbol) No. of Activity Values Activity Value (nM) Activity Type Activity Reference
NPC100887 AMY1A;AMY1B;AMY1C 1 48000 IC50 PMID: 18507367
NPC100887 BLM 1 44668.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC100887 MAPT 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC156654 L3MBTL1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC156654 KDM4E 1 35481.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC156654 POLB 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 DPP4 1 37150 IC50 DOI: 10.1039/C0MD00245C
NPC169749 ALPL 1 33200 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 ALPPL2 1 32300 EC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 KMT2A 1 31622.8 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 AMY1A;AMY1B;AMY1C 1 30200 IC50 PMID: 18507367
NPC169749 AKR1B1 1 29000 IC50 PMID: 18165015
NPC169749 CD38 1 24800 IC50 PMID: 21641214
NPC169749 DAPK1 1 23000 IC50 PMID: 26322379
NPC169749 ABCC2 1 22000 IC50 PMID: 19725578
NPC169749 ABCC1 1 20000 IC50 PMID: 19725578
NPC169749 CYP2D6 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 APOBEC3A 1 17500 IC50 PubChem BioAssay data set
CHEMBL1201862
NPC169749 MTOR 2 Median: 19881.25
Range: 16481.6 to 23280.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC169749 BLM 3 Median: 14125.4
Range: 14125.4 to 14125.4
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC169749 ALOX12 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 MAPK1 1 39810.7 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 TDP1 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 TP53 2 Median: 28370.85
Range: 25118.9 to 31622.8
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC241498 ATM 1 25118.9 Potency PubChem BioAssay data set
CHEMBL1201862
NPC241498 TDP1 2 Median: 46590.9
Range: 22387.2 to 70794.6
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC241498 MAPT 1 19952.6 Potency PubChem BioAssay data set
CHEMBL1201862
NPC169749 HSP90AB1 1 13500 IC50 PMID: 24548207
NPC231772 LMNA 1 14125.4 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 SMN1;SMN2 2 Median: 19622.15
Range: 14125.4 to 25118.9
Potency PubChem BioAssay data set
CHEMBL1201862
PubChem BioAssay data set
CHEMBL1201862
NPC231772 USP2 1 12589.3 Potency PubChem BioAssay data set
CHEMBL1201862
NPC231772 CYP2D6 1 12589.25 AC50 PubChem BioAssay data set
CHEMBL1201862
NPC294852 CYP1A1 1 10973 IC50 PMID: 20696580