Plant Name: Cissampelos pareira
Taxonomic Information:
Plant ID: NPO13978
Plant Latin Name: Cissampelos pareira
Taxonomy Genus: Cissampelos
Taxonomy Family: Menispermaceae
Plant External Links:
NCBI TaxonomyDB:
108409
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Pakistan; Tanzania; Indonesia; India; Rwanda; China; Vietnam; Thailand; Kenya; Argentina; PhilippinesTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM; HomeopathyGeographical Distribution:
Pakistan; Philippines; Indonesia; India; Rwanda; China; Vietnam; Thailand; Kenya; Argentina; Tanzania
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| PTPN1; PTPN2; CDC25B; | |
| BCHE; ACHE; | |
| PLA2G1B; FAAH; TERT; AKR1B10; USP2; POLB; | |
| PPARA; PPARD; PPARG; | |
| NR1H4; | |
| HIF1A; | |
| HTT; FABP5; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Hydrolase | BCHE | Butyrylcholinesterase | P06276 | CHEMBL1914 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 5.145E-08 | 1.900E-04 | BCHE, CYP1A2, CYP2D6 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 2.117E-07 | 5.761E-04 | NR1H4, PPARA, PPARD, PPARG, PTPN2 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 3.123E-07 | 6.182E-04 | NR1H4, PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 6.656E-07 | 9.662E-04 | NR1H4, PPARA, PPARD, PPARG |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 1.011E-06 | 1.101E-03 | CDC25B, FABP5, HIF1A, HTT, NR1H4, POLB, PPARA, PPARD, PPARG, PTPN2, SMN1, SMN2, TERT, USP2 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 1.114E-06 | 1.155E-03 | PLA2G1B, PPARA, PPARD, PPARG |
| MF | GO:0003824; catalytic activity | GO:0003990; acetylcholinesterase activity | 1.356E-06 | 1.284E-03 | ACHE, BCHE |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 4.066E-06 | 2.767E-03 | GPBAR1, NR1H4 |
| MF | GO:0005488; binding | GO:0008134; transcription factor binding | 3.832E-06 | 2.767E-03 | HIF1A, HTT, NR1H4, PPARA, PPARD, PPARG, TERT |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 4.066E-06 | 2.767E-03 | GPBAR1, NR1H4 |
| BP | GO:0032502; developmental process | GO:0048513; animal organ development | 4.609E-06 | 2.952E-03 | ACHE, CYP1A2, HIF1A, HTT, POLB, PPARA, PPARD, PPARG, USP2 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 8.126E-06 | 4.423E-03 | PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 9.152E-06 | 4.635E-03 | AKR1B10, CYP1A2, CYP2D6, NR1H4, PPARD |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 1.353E-05 | 5.885E-03 | PPARA, PPARG |
| MF | GO:0005488; binding | GO:0019899; enzyme binding | 1.409E-05 | 5.885E-03 | BCHE, CDC25B, CYP1A2, HIF1A, HTT, POLB, PPARA, PPARG, PTPN1, PTPN2, USP2 |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 1.571E-05 | 6.300E-03 | NR1H4, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 2.028E-05 | 7.011E-03 | PPARA, PPARG |
| BP | GO:0009987; cellular process | GO:0060336; negative regulation of interferon-gamma-mediated signaling pathway | 2.028E-05 | 7.011E-03 | PPARG, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 2.028E-05 | 7.011E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 2.028E-05 | 7.011E-03 | CYP1A2, CYP2D6 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 2.622E-05 | 8.273E-03 | NR1H4, PTPN1, PTPN2 |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 8.887E-05 | 1.861E-02 | SMN1, SMN2 |
| CC | GO:0032991; macromolecular complex | GO:0032797; SMN complex | 1.049E-04 | 2.059E-02 | SMN1, SMN2 |
| CC | GO:0044464; cell part | GO:0034719; SMN-Sm protein complex | 2.051E-04 | 3.284E-02 | SMN1, SMN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.093E-06 | 6.450E-05 | FABP5, PPARG, PPARA, PPARD |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.040E-04 | 1.487E-02 | PLA2G1B, CYP1A2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 2.832E-03 | 4.666E-02 | CYP2D6, CYP1A2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 3.164E-03 | 4.666E-02 | CYP2D6, CYP1A2 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.024E-02 | 7.550E-02 | PPARG, HIF1A, PPARD |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00564 | Glycerophospholipid metabolism | 5.293E-03 | 5.642E-02 | ACHE, PLA2G1B |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 6.910E-03 | 5.824E-02 | PTPN1, PPARA |
| 09120 Genetic Information Processing | 09122 Translation | hsa03013 | RNA transport | 1.652E-02 | 1.083E-01 | SMN2, SMN1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 2.052E-02 | 1.211E-01 | HTT, PPARG |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 5.737E-03 | 5.642E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
| NA: NA | Upper abdominal bloating | NA | ACHE; |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE; |
| C00-D49: Neoplasms | Cancer | C00-C96 | ACHE; CDC25B; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE; |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
