CMAUP Plant Collective Molecular Activities

Plant Name: Selaginella uncinata

Taxonomic Information:

Plant ID: NPO13931
Plant Latin Name: Selaginella uncinata
Taxonomy Genus: Selaginella
Taxonomy Family: Selaginellaceae

Plant External Links:

NCBI TaxonomyDB: 307165
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR2C; DRD3;
Peptide receptor (family A GPCR)	OPRD1;
Protein Phosphatase	PTPN1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Enzyme_unclassified	ALOX15; HSD17B10; ALDH1A1; USP2;
Aspartic protease	BACE1;
Endoplasmic reticular retrotranslocon family	VCP;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	SERPINA6; MCL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Endoplasmic reticular retrotranslocon family	VCP	Transitional endoplasmic reticulum ATPase	P55072	CHEMBL1075145
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Unclassified	SERPINA6	Corticosteroid binding globulin	P08185	CHEMBL2421
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015908; fatty acid transport	3.041E-07	1.104E-03	DRD3, PPARA, PPARD, PPARG
BP	GO:0048511; rhythmic process	GO:0042752; regulation of circadian rhythm	1.409E-06	3.836E-03	DRD3, PPARA, PPARG, USP2
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	7.279E-06	1.585E-02	PPARA, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	1.091E-05	1.588E-02	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	1.091E-05	1.588E-02	PPARA, PPARG
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.017E-05	1.588E-02	PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0019902; phosphatase binding	1.094E-05	1.588E-02	PPARA, PPARG, PTPN1, VCP
MF	GO:0005488; binding	GO:0008289; lipid binding	1.612E-05	1.847E-02	ALOX15, PPARA, PPARD, PPARG, SERPINA6, VCP
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	1.785E-05	1.851E-02	PPARA, PPARD, PPARG
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	3.991E-05	3.471E-02	PPARD, PPARG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.581E-05	1.007E-03	PPARG, PPARA, PPARD
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.548E-03	2.122E-02	OPRD1, HTR2C, DRD3
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.633E-03	2.122E-02	SLCO1B1, SLCO1B3
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	3.794E-03	3.121E-02	PTPN1, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.001E-03	3.121E-02	ALOX15, HTR2C
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	8.781E-03	5.708E-02	BACE1, HSD17B10
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.438E-02	1.188E-01	PPARG
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.438E-02	1.188E-01	ALOX15
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	5.789E-02	1.489E-01	PPARA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	6.110E-02	1.489E-01	PTPN1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1;
NA: NA	Acute nonspecific diarrhea	NA	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRD1;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1;
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1;
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases