CMAUP Plant Collective Molecular Activities

Plant Name: Selaginella uncinata

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015908; fatty acid transport	3.041E-07	1.104E-03	DRD3, PPARA, PPARD, PPARG
BP	GO:0048511; rhythmic process	GO:0042752; regulation of circadian rhythm	1.409E-06	3.836E-03	DRD3, PPARA, PPARG, USP2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	2.581E-05	1.007E-03	PPARG; PPARA; PPARD
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.548E-03	2.122E-02	OPRD1; HTR2C; DRD3
hsa04976	Bile secretion_Homo sapiens_hsa04976	1.633E-03	2.122E-02	SLCO1B1; SLCO1B3
hsa04931	Insulin resistance_Homo sapiens_hsa04931	3.794E-03	3.121E-02	PTPN1; PPARA
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	4.001E-03	3.121E-02	ALOX15; HTR2C

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD3; HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1
NA: NA	Acute nonspecific diarrhea	NA	OPRD1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; PPARD; PPARG; PPARG
NA: NA	Primary insomnia	NA	HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	HTR2C; OPRD1
C00-D49: Neoplasms	Aggressive non-hodgkin's lymphoma	C81, C81-C86, C82-C85, C91-C95	HTR2C
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PPARG
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HTR2C; HTR2C; PPARD; PPARD; PPARG
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD; PPARG
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR2C
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR2C
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	PPARG
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR2C; HTR2C; OPRD1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR2C; OPRD1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HTR2C; PPARG
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2C
NA: NA	Obstructive airway diseases	NA	SERPINA6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic macular edema	E08-E13, E08.3, E09.3, E10.3, E11.3, E13.3, H35.8, R60.9	SERPINA6
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	SERPINA6
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	HTR2C; OPRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3; HTR2C; PPARG
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1
NA: NA	Colour dead tissues	NA	PTPN1
NA: NA	Sleep initiation and maintenance disorders	NA	HTR2C
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
NA: NA	Dyslipidemia	NA	PPARD
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PPARG
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PPARG; PPARG
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR2C
J00-J99: Diseases of the respiratory system	Asthma	J45	SERPINA6
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	SERPINA6
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD; PPARG
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD3; HTR2C
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
C00-D49: Neoplasms	Cancer	C00-C96	MCL1
C00-D49: Neoplasms	Multiple myeloma	C90	VCP
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HTR2C
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases