Plant Name: Magnolia liliiflora
Taxonomic Information:
Plant ID: NPO13730
Plant Latin Name: Magnolia liliiflora
Taxonomy Genus: Magnolia
Taxonomy Family: Magnoliaceae
Plant External Links:
NCBI TaxonomyDB:
3403
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Unknown.
Geographical Distribution:
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CNR1; CNR2; PTAFR; | |
| TDP1; | |
| TRPA1; | |
| MAPK1; | |
| PPARA; | |
| PTGS1; | |
| TLR2; | |
| MAPT; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP3A4; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Small molecule receptor (family A GPCR) | CNR1 | Cannabinoid CB1 receptor | P21554 | CHEMBL218 |
| Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Small molecule receptor (family A GPCR) | PTAFR | Platelet activating factor receptor | P25105 | CHEMBL250 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0019233; sensory perception of pain | 2.459E-08 | 5.355E-04 | CNR1, CNR2, MAPK1, TRPA1 |
| BP | GO:0050896; response to stimulus | GO:0031663; lipopolysaccharide-mediated signaling pathway | 8.154E-07 | 5.000E-03 | MAPK1, PTAFR, TLR2 |
| MF | GO:0060089; molecular transducer activity | GO:0004949; cannabinoid receptor activity | 1.061E-06 | 5.000E-03 | CNR1, CNR2 |
| BP | GO:0065007; biological regulation | GO:0045776; negative regulation of blood pressure | 2.074E-06 | 5.514E-03 | CNR1, PPARA, PTAFR |
| BP | GO:0009987; cellular process | GO:0038171; cannabinoid signaling pathway | 2.121E-06 | 5.514E-03 | CNR1, CNR2 |
| BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 2.294E-06 | 5.514E-03 | CNR1, CNR2, MAPK1, PTAFR, TLR2, TRPA1 |
| BP | GO:0050896; response to stimulus | GO:0009636; response to toxic substance | 2.674E-06 | 5.514E-03 | CNR1, CNR2, MAPK1, TLR2, TRPA1 |
| BP | GO:0050896; response to stimulus | GO:0010243; response to organonitrogen compound | 2.785E-06 | 5.514E-03 | CNR1, CNR2, MAPK1, PPARA, PTAFR, TLR2 |
| MF | GO:0060089; molecular transducer activity | GO:0001875; lipopolysaccharide receptor activity | 3.534E-06 | 5.920E-03 | PTAFR, TLR2 |
| BP | GO:0008152; metabolic process | GO:0051001; negative regulation of nitric-oxide synthase activity | 7.417E-06 | 8.973E-03 | CNR1, CNR2 |
| MF | Unclassified; | GO:0004871; signal transducer activity | 2.280E-05 | 1.747E-02 | CNR1, CNR2, MAPK1, PPARA, PTAFR, TLR2, TRPA1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 5.270E-04 | 3.423E-02 | CNR2, CNR1, PTAFR |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 8.470E-04 | 3.423E-02 | MAPK1, TLR2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04723 | Retrograde endocannabinoid signaling | 1.612E-03 | 3.423E-02 | CNR1, MAPK1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 1.774E-03 | 3.423E-02 | MAPK1, TLR2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05142 | Chagas disease (American trypanosomiasis) | 1.708E-03 | 3.423E-02 | MAPK1, TLR2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.978E-03 | 3.423E-02 | MAPK1, PTGS1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 2.192E-03 | 3.423E-02 | MAPK1, TLR2 |
| 09150 Organismal Systems | 09151 Immune system | hsa04611 | Platelet activation | 2.340E-03 | 3.423E-02 | MAPK1, PTGS1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 3.067E-03 | 3.541E-02 | LMNA, MAPK1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 2.773E-03 | 3.541E-02 | MAPK1, PPARA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | PTAFR; |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTAFR; |
| H00-H59: Diseases of the eye and adnexa | Conjunctivitis | H10 | PTAFR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Thrombocytopenia | D69.6, P61.0 | PTAFR; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PTAFR; |
| H00-H59: Diseases of the eye and adnexa | Ocular allergy | H00-H59 | PTAFR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MAPK1; |
| I00-I99: Diseases of the circulatory system | Cardiac arrhythmias | I47-I49 | PTAFR; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | PTAFR; |
| G00-G99: Diseases of the nervous system G00-G99 | Brain ischaemia | G45.9, I67.8 | PTAFR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | PTAFR; MAPK1; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTAFR; |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PTAFR; |
| A00-B99: Certain infectious and parasitic diseases | Septic shock | A41.9 | PTAFR; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | PTAFR; |
| I00-I99: Diseases of the circulatory system | Cerebral infarction | I63 | PTAFR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
