CMAUP Plant Collective Molecular Activities

Plant Name: Magnolia liliiflora

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0019233; sensory perception of pain	2.459E-08	5.355E-04	CNR1, CNR2, MAPK1, TRPA1
BP	GO:0050896; response to stimulus	GO:0031663; lipopolysaccharide-mediated signaling pathway	8.154E-07	5.000E-03	MAPK1, PTAFR, TLR2
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	1.061E-06	5.000E-03	CNR1, CNR2
BP	GO:0065007; biological regulation	GO:0045776; negative regulation of blood pressure	2.074E-06	5.514E-03	CNR1, PPARA, PTAFR
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	2.121E-06	5.514E-03	CNR1, CNR2
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	2.294E-06	5.514E-03	CNR1, CNR2, MAPK1, PTAFR, TLR2, TRPA1
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	2.674E-06	5.514E-03	CNR1, CNR2, MAPK1, TLR2, TRPA1
BP	GO:0050896; response to stimulus	GO:0010243; response to organonitrogen compound	2.785E-06	5.514E-03	CNR1, CNR2, MAPK1, PPARA, PTAFR, TLR2
BP	GO:0050896; response to stimulus	GO:1901700; response to oxygen-containing compound	3.322E-06	5.920E-03	CNR1, CNR2, MAPK1, PPARA, PTAFR, TLR2, TRPA1
MF	GO:0060089; molecular transducer activity	GO:0001875; lipopolysaccharide receptor activity	3.534E-06	5.920E-03	PTAFR, TLR2
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	7.417E-06	8.973E-03	CNR1, CNR2
BP	GO:0050896; response to stimulus	GO:0080134; regulation of response to stress	8.059E-06	9.236E-03	CNR1, CNR2, LMNA, MAPK1, MAPT, PPARA, TLR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	5.270E-04	3.423E-02	CNR2; CNR1; PTAFR
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	8.470E-04	3.423E-02	MAPK1; TLR2
hsa04723	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.612E-03	3.423E-02	CNR1; MAPK1
hsa04620	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.774E-03	3.423E-02	MAPK1; TLR2
hsa05142	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.708E-03	3.423E-02	MAPK1; TLR2
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	1.978E-03	3.423E-02	MAPK1; PTGS1
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	2.192E-03	3.423E-02	MAPK1; TLR2
hsa04611	Platelet activation_Homo sapiens_hsa04611	2.340E-03	3.423E-02	MAPK1; PTGS1
hsa04210	Apoptosis_Homo sapiens_hsa04210	3.067E-03	3.541E-02	LMNA; MAPK1
hsa05160	Hepatitis C_Homo sapiens_hsa05160	2.773E-03	3.541E-02	MAPK1; PPARA
hsa05161	Hepatitis B_Homo sapiens_hsa05161	3.330E-03	3.541E-02	MAPK1; TLR2
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	4.380E-03	4.271E-02	MAPK1; MAPT
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	6.328E-03	4.936E-02	MAPK1; TLR2
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	6.089E-03	4.936E-02	MAPK1; PPARA
hsa05152	Tuberculosis_Homo sapiens_hsa05152	4.903E-03	4.412E-02	MAPK1; TLR2
hsa04015	Rap1 signaling pathway_Homo sapiens_hsa04015	6.820E-03	4.987E-02	CNR1; MAPK1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	PTAFR
J00-J99: Diseases of the respiratory system	Throat irritation	J39.2	TRPA1
C00-D49: Neoplasms	Melanoma	C43	TLR2
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	CNR1; CNR1; CNR1; CNR1; CNR1; CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	CNR1; CNR1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	CNR1
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	CNR1
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1; CNR2; PTAFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CNR1
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2
H00-H59: Diseases of the eye and adnexa	Conjunctivitis	H10	PTAFR
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	CNR1
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chemotherapy-induced nausea	R11	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Thrombocytopenia	D69.6, P61.0	PTAFR
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2
C00-D49: Neoplasms	Ovarian cancer	C56	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1
C00-D49: Neoplasms	Prostate cancer	C61	TLR2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR1; PTGS1; CNR2; TRPA1; PTAFR
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR1; PTGS1; CNR2
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	PTGS1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	CNR1; MAPT
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	CNR1
H00-H59: Diseases of the eye and adnexa	Ocular allergy	H00-H59	PTAFR
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	CNR1; CNR1; CNR1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	CNR1
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CNR2
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PTAFR
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TLR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	PTAFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anorexia	F50.0-F50.1	CNR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	CNR1
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	PTAFR
G00-G99: Diseases of the nervous system G00-G99	Brain ischaemia	G45.9, I67.8	PTAFR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	CNR1
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; PTAFR; TLR2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1; CNR2; PTAFR
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1
J00-J99: Diseases of the respiratory system	Asthma	J45	PTAFR
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	PTAFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CNR1
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PTAFR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CNR2
NA: NA	Rheumatold arthritis	NA	PTGS1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CNR1
NA: NA	Miosis during ocular surgery	NA	PTGS1
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	PTAFR
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	PTAFR
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases