CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; BLM; AOX1;
Protein Kinase	EGFR;
Lyase	CA4; CA12; CA7;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Oxidoreductase	ALDH2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751

Showing 1 to 10 of 15 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	2.524E-06	5.273E-03	ESR1, ESR2, ESRRA, ESRRB
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.664E-06	5.273E-03	CA12, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.923E-06	8.245E-03	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	5.764E-06	8.368E-03	ESR1, ESR2, ESRRA, ESRRB
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.709E-08	2.660E-04	BLM, CA12, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.714E-07	5.332E-04	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0005496; steroid binding	4.815E-07	1.311E-03	ESR1, ESR2, ESRRA, ESRRB
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	5.629E-07	1.362E-03	ESR1, ESR2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	3.374E-06	6.123E-03	ESR1, ESR2

Showing 1 to 9 of 9 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.306E-07	1.707E-05	CA12, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.028E-04	9.937E-03	ALDH2, AOX1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	5.127E-05	1.897E-03	ESR1, EGFR, ESR2

Showing 1 to 3 of 3 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
C00-D49: Neoplasms	Pancreatic cancer	C25	EGFR;
C00-D49: Neoplasms	Ovarian cancer	C56	EGFR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
C00-D49: Neoplasms	Lymphoma	C81-C86	EGFR;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Bertya dimerostigma

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities