CMAUP Plant Collective Molecular Activities

Plant Name: Zanthoxylum brachyacanthum

Taxonomic Information:

Plant ID: NPO13676
Plant Latin Name: Zanthoxylum brachyacanthum
Taxonomy Genus: Zanthoxylum
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 1056464
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF;
Enzyme_unclassified	RECQL; HSD11B1; AKR1B10; CD38;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4; CYP2C19; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	CD38	Lymphocyte differentiation antigen CD38	P28907	CHEMBL4660
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.703E-12	1.024E-07	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	5.326E-10	5.798E-06	AKR1B10, CYP1A2, CYP2C19, CYP2D6, CYP3A4, HSD11B1, NR1H4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	2.718E-08	1.184E-04	CYP1A2, CYP2C19, CYP2D6, CYP3A4, RORC
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.582E-08	1.425E-04	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.021E-07	2.471E-04	CYP1A2, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.021E-07	2.471E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	8.175E-07	1.780E-03	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.127E-06	1.976E-03	ACP1, PTPN1, PTPN2, PTPRF
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.929E-06	2.399E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.929E-06	2.399E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.929E-06	2.399E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.747E-06	3.148E-03	CYP2C19, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	3.148E-06	3.427E-03	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	3.856E-06	3.651E-03	PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.856E-06	3.651E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	7.636E-06	6.395E-03	CYP1A2, CYP2C19, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	8.394E-06	6.769E-03	NR1H4, PTPN1, PTPN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2.288E-07	5.032E-06	CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.875E-07	5.032E-06	HSD11B1, CYP2D6, CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.601E-07	5.367E-06	HSD11B1, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.516E-06	1.326E-05	CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.262E-05	8.833E-05	HSD11B1, CYP1A2, CYP3A4
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.630E-05	1.534E-04	PTPN1, ACP1, PTPRF
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.608E-04	1.304E-03	HSD11B1, AKR1B10, CYP1A2, CD38, CYP2C19, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.212E-03	5.302E-03	CYP1A2, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.444E-03	5.615E-03	NR1H4, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	3.543E-03	1.127E-02	CYP2D6, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases