Plant Name: Zanthoxylum brachyacanthum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 4.703E-12 | 1.024E-07 | CYP1A2, CYP2C19, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 5.326E-10 | 5.798E-06 | AKR1B10, CYP1A2, CYP2C19, CYP2D6, CYP3A4, HSD11B1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 2.718E-08 | 1.184E-04 | CYP1A2, CYP2C19, CYP2D6, CYP3A4, RORC |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 4.582E-08 | 1.425E-04 | CYP1A2, CYP2C19, CYP2D6, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.021E-07 | 2.471E-04 | CYP1A2, CYP2C19, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 1.021E-07 | 2.471E-04 | CYP1A2, CYP2D6, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 8.175E-07 | 1.780E-03 | CYP1A2, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 1.127E-06 | 1.976E-03 | ACP1, PTPN1, PTPN2, PTPRF |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 1.929E-06 | 2.399E-03 | CYP2D6, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 1.929E-06 | 2.399E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 1.929E-06 | 2.399E-03 | GPBAR1, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 2.747E-06 | 3.148E-03 | CYP2C19, CYP2D6, CYP3A4 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 3.148E-06 | 3.427E-03 | CYP1A2, CYP2C19, CYP2D6, CYP3A4 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 3.856E-06 | 3.651E-03 | PTPN1, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 3.856E-06 | 3.651E-03 | CYP1A2, CYP3A4 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 7.636E-06 | 6.395E-03 | CYP1A2, CYP2C19, CYP2D6, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 8.394E-06 | 6.769E-03 | NR1H4, PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0019748; secondary metabolic process | 9.478E-06 | 7.371E-03 | AKR1B10, CYP1A2, CYP2D6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.288E-07 | 5.032E-06 | CYP2D6; CYP1A2; CYP3A4; CYP2C19 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.875E-07 | 5.032E-06 | HSD11B1; CYP2D6; CYP1A2; CYP3A4 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 4.601E-07 | 5.367E-06 | HSD11B1; CYP1A2; CYP3A4; CYP2C19 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.516E-06 | 1.326E-05 | CYP1A2; CYP3A4; CYP2C19 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.262E-05 | 8.833E-05 | HSD11B1; CYP1A2; CYP3A4 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 2.630E-05 | 1.534E-04 | PTPN1; ACP1; PTPRF |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.608E-04 | 1.304E-03 | HSD11B1; AKR1B10; CYP1A2; CD38; CYP2C19; CYP3A4 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.212E-03 | 5.302E-03 | CYP1A2; CYP3A4 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 1.444E-03 | 5.615E-03 | NR1H4; CYP3A4 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 3.360E-03 | 1.127E-02 | PTPN1; PTPRF |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 3.543E-03 | 1.127E-02 | CYP2D6; CYP2C19 |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 5.399E-03 | 1.454E-02 | PTPN1; PTPRF |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.994E-03 | 1.165E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CD38 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; GPBAR1; HSD11B1 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | CD38 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSD11B1; HSD11B1 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | CD38 |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1 |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6 |