CMAUP Plant Collective Molecular Activities

Plant Name: Callicarpa macrophylla

Taxonomic Information:

Plant ID: NPO13153
Plant Latin Name: Callicarpa macrophylla
Taxonomy Genus: Callicarpa
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 536997
Plant-of-the-World-Online: 861393-1

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

Sowa-Rigpa; TCM; Ayurveda

Medicinal Functions:

Antirheumatic; Aromatic; Poultice; Stomachic

Geographical Distribution:

Australia; Bangladesh; Myanmar; Philippines; Nepal; India; Vietnam; China; Laos; Sri Lanka; Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1; HCAR2;
Protein Kinase	PRKCA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	AKR1B10;
Metallo protease	MMP12; MMP2;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	2.822E-07	4.201E-03	NR1H4, SLCO1B1, SLCO1B3
BP	GO:0009987; cellular process	GO:0050708; regulation of protein secretion	2.643E-05	9.149E-02	HCAR2, MMP12, NR1H4, PRKCA
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	2.941E-05	9.149E-02	SLCO1B1, SLCO1B3
BP	GO:0002376; immune system process	GO:0002684; positive regulation of immune system process	4.107E-05	9.936E-02	HCAR2, MMP12, MMP2, NR1H4, PRKCA
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	5.404E-05	1.070E-01	HCAR2, NR1H4, PRKCA, SLCO1B1
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	5.298E-05	1.070E-01	SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	7.249E-05	1.315E-01	SLCO1B1, SLCO1B3
MF	GO:0005488; binding	GO:0008270; zinc ion binding	3.313E-04	2.071E-01	MMP12, MMP2, NR1H4, PRKCA
MF	GO:0003824; catalytic activity	GO:0035403; histone kinase activity (H3-T6 specific)	9.317E-04	2.742E-01	PRKCA
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.176E-03	5.619E-01	SLCO1B1, SLCO1B3
CC	GO:0016020; membrane	GO:0005886; plasma membrane	6.142E-03	7.686E-01	GPBAR1, HCAR2, MMP2, PRKCA, SLCO1B1, SLCO1B3
CC	GO:0044421; extracellular region part	GO:0005578; proteinaceous extracellular matrix	7.048E-03	8.386E-01	MMP12, MMP2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.547E-06	2.412E-04	SLCO1B1, SLCO1B3, NR1H4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8.883E-04	2.013E-02	MMP2, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	7.220E-04	2.013E-02	MMP2, PRKCA
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	1.209E-03	2.056E-02	MMP2, PRKCA
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	3.521E-03	4.789E-02	MMP2, PRKCA
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.290E-02	7.019E-02	MMP2, PRKCA
09160 Human Diseases	09167 Infectious diseases	hsa05143	African trypanosomiasis	1.564E-02	7.019E-02	PRKCA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.342E-02	7.019E-02	AKR1B10
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	4.239E-02	7.019E-02	PRKCA
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	4.455E-02	7.019E-02	PRKCA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases