CMAUP Plant Collective Molecular Activities

Plant Name: Gynostemma pentaphyllum

Taxonomic Information:

Plant ID: NPO12934
Plant Latin Name: Gynostemma pentaphyllum
Taxonomy Genus: Gynostemma
Taxonomy Family: Cucurbitaceae

Plant External Links:

NCBI TaxonomyDB: 182084
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

TCM; Ayurveda

Medicinal Functions:

Alterative; Anticholesterolemic; Antispasmodic; Hepatic; Hypoglycaemic; Sedative; Tonic

Geographical Distribution:

India; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Phosphodiesterase 4	PDE4D;
Transcription Factor	STAT3;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Phosphodiesterase 4	PDE4D	Phosphodiesterase 4D	Q08499	CHEMBL288
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0042326; negative regulation of phosphorylation	3.231E-07	6.428E-03	PDE4D, PTPN1, STAT3, XDH
BP	GO:0050896; response to stimulus	GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway	3.374E-06	1.837E-02	PTPN1, STAT3
BP	GO:0008152; metabolic process	GO:0001932; regulation of protein phosphorylation	2.617E-05	6.306E-02	PDE4D, PTPN1, STAT3, XDH
BP	GO:0008152; metabolic process	GO:0006195; purine nucleotide catabolic process	2.896E-05	6.306E-02	PDE4D, XDH
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	2.203E-04	1.499E-01	PTPN1, STAT3
MF	GO:0005488; binding	GO:0001664; G-protein coupled receptor binding	1.097E-03	2.912E-01	PDE4D, STAT3
CC	GO:0044464; cell part	GO:0097443; sorting endosome	1.242E-03	3.073E-01	PTPN1
MF	GO:0005488; binding	GO:0043546; molybdopterin cofactor binding	1.242E-03	3.073E-01	XDH
CC	GO:0044464; cell part	GO:0005829; cytosol	3.935E-03	4.632E-01	PDE4D, PTPN1, STAT3, XDH

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	1.753E-04	5.260E-03	PTPN1, STAT3
09100 Metabolism	09104 Nucleotide metabolism	hsa00230	Purine metabolism	4.567E-04	6.850E-03	PDE4D, XDH
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	1.294E-02	4.126E-02	STAT3
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.432E-02	4.126E-02	STAT3
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.472E-02	4.126E-02	PTPN1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	9.997E-04	9.997E-03	XDH
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	1.808E-02	4.126E-02	PDE4D
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.044E-02	4.126E-02	STAT3
09140 Cellular Processes	09141 Transport and catabolism	hsa04146	Peroxisome	1.650E-02	4.126E-02	XDH
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	2.339E-02	4.126E-02	STAT3

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	STAT3;
C00-D49: Neoplasms	Multiple myeloma	C90	STAT3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3;
C00-D49: Neoplasms	Cancer	C00-C96	STAT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	STAT3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases