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Plant Name: Gynostemma pentaphyllum




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 PTPN1
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH
J00-J99: Diseases of the respiratory system Emphysema J43 PDE4D
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 PTPN1; PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH
J00-J99: Diseases of the respiratory system Asthma J45 PDE4D; PDE4D
NA: NA Colour dead tissues NA PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 PDE4D
C00-D49: Neoplasms Solid tumours C00-D48 STAT3
C00-D49: Neoplasms Multiple myeloma C90 STAT3
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 STAT3
J00-J99: Diseases of the respiratory system Bronchitis J20-J21, J42 PDE4D
C00-D49: Neoplasms Cancer C00-C96 STAT3
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 STAT3; PDE4D
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 XDH
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 PDE4D; PDE4D; PDE4D
I00-I99: Diseases of the circulatory system Heart failure I50 XDH
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Singapore, 117549, National University of Singapore

Principle Investigator:
Prof. Chen Yu Zong
phacyz@nus.edu.sg

Developer & Maintainer:
Dr. Zeng Xian
zengxian@u.edu.nus

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