CMAUP Plant Collective Molecular Activities

Plant Name: Siphonostegia chinensis

Taxonomic Information:

Plant ID: NPO12755
Plant Latin Name: Siphonostegia chinensis
Taxonomy Genus: Siphonostegia
Taxonomy Family: Orobanchaceae

Plant External Links:

NCBI TaxonomyDB: 374729
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK1;
Lyase	CA13; CA12; CA9;
Enzyme_unclassified	ALDH1A1; AKR1B10; AKR1B1;
Serine protease	ELANE;
Unclassified	APP; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2A6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Serine protease	ELANE	Leukocyte elastase	P08246	CHEMBL248
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.300E-08	9.037E-04	CA12, CA13, CA9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.417E-07	1.754E-03	AKR1B1, AKR1B10, APP, CYP2A6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006066; alcohol metabolic process	4.191E-07	2.282E-03	AKR1B1, AKR1B10, ALDH1A1, APP, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.293E-06	5.631E-03	CA12, CA13, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.392E-06	7.439E-03	CA12, CA13, CA9
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.392E-06	7.439E-03	AKR1B1, AKR1B10, ALDH1A1
BP	GO:0008152; metabolic process	GO:0044597; daunorubicin metabolic process	9.886E-06	1.296E-02	AKR1B1, AKR1B10
MF	GO:0003824; catalytic activity	GO:0001758; retinal dehydrogenase activity	7.417E-06	1.296E-02	AKR1B10, ALDH1A1
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	8.581E-06	1.296E-02	AKR1B1, MAPK1, MAPT
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	1.983E-05	2.056E-02	APP, CA12, CA13, CA9, CYP2A6, CYP3A4
CC	Unclassified;	GO:0097386; glial cell projection	4.787E-05	3.754E-02	AKR1B1, APP

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.117E-07	1.150E-05	CA12, CA9, CA13
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.059E-06	3.635E-04	CYP2A6, ALDH1A1, CYP3A4
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.211E-04	3.338E-03	APP, MAPK1, MAPT
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.965E-04	6.341E-03	CYP2A6, AKR1B10, ALDH1A1, AKR1B1, CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.056E-04	3.529E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.422E-04	3.338E-03	AKR1B10, AKR1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3.366E-04	4.953E-03	CYP2A6, CYP3A4
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.621E-04	3.338E-03	AKR1B10, AKR1B1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	5.540E-04	6.341E-03	AKR1B10, AKR1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.571E-04	7.798E-03	CYP2A6, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8.470E-04	7.931E-03	CYP2A6, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.067E-03	9.160E-03	CYP2A6, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	APP;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	APP;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP;
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP;
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP;
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1;
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	APP;
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1;
C00-D49: Neoplasms	Glioma	C71	APP;
NA: NA	Geographic retinal atrophy	NA	APP;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; APP;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases