CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.300E-08	9.037E-04	CA12, CA13, CA9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.417E-07	1.754E-03	AKR1B1, AKR1B10, APP, CYP2A6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006066; alcohol metabolic process	4.191E-07	2.282E-03	AKR1B1, AKR1B10, ALDH1A1, APP, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.293E-06	5.631E-03	CA12, CA13, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.392E-06	7.439E-03	CA12, CA13, CA9
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.392E-06	7.439E-03	AKR1B1, AKR1B10, ALDH1A1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	1.117E-07	1.150E-05	CA12; CA9; CA13
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	7.059E-06	3.635E-04	CYP2A6; ALDH1A1; CYP3A4
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	1.211E-04	3.338E-03	APP; MAPK1; MAPT
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	4.965E-04	6.341E-03	CYP2A6; AKR1B10; ALDH1A1; AKR1B1; CYP3A4
hsa00040	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.056E-04	3.529E-03	AKR1B10; AKR1B1
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	1.422E-04	3.338E-03	AKR1B10; AKR1B1
hsa00983	Drug metabolism - other enzymes_Homo sapiens_hsa00983	3.366E-04	4.953E-03	CYP2A6; CYP3A4
hsa00051	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.621E-04	3.338E-03	AKR1B10; AKR1B1
hsa00561	Glycerolipid metabolism_Homo sapiens_hsa00561	5.540E-04	6.341E-03	AKR1B10; AKR1B1
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	7.571E-04	7.798E-03	CYP2A6; CYP3A4
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	8.470E-04	7.931E-03	CYP2A6; CYP3A4
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	1.978E-03	1.567E-02	APP; MAPK1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.067E-03	9.160E-03	CYP2A6; CYP3A4
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	2.997E-03	2.205E-02	CYP2A6

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	APP
J00-J99: Diseases of the respiratory system	Pulmonary emphysema	J43	ELANE
J00-J99: Diseases of the respiratory system	Pulmonary disease	J00-J99	ELANE
NA: NA	Acute respiratory distress syndrome	NA	ELANE; ELANE; ELANE
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
C00-D49: Neoplasms	Breast cancer	C50	CA9
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	APP
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; CA9
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ELANE
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP
J00-J99: Diseases of the respiratory system	Asthma	J45	ELANE
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	ELANE
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP
NA: NA	Myocardial ischaemia-reperfusion injury	NA	ELANE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ELANE; AKR1B1
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	ELANE; ELANE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT; APP
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
C00-D49: Neoplasms	Glioma	C71	APP
NA: NA	Geographic retinal atrophy	NA	APP
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
J00-J99: Diseases of the respiratory system	Mucolytic	J00-J99	ELANE
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	ELANE; ELANE; ELANE
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	ELANE
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ELANE; ELANE
J00-J99: Diseases of the respiratory system	Bronchiectasis	J47, Q33.4	ELANE
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
C00-D49: Neoplasms	Renal cancer	C64	CA9
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; CA9; APP

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Siphonostegia chinensis

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases