CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; FFAR1; FFAR4;
Small molecule receptor (family C GPCR)	GRM1; GRM8;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	RECQL; HSD11B1; ALOX12; HSD17B10; AKR1B10; ALOX15; NOX4; POLB;
Protein Phosphatase	CDC25B;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
Protein Kinase	MET; FLT3; CDK1; MAPK1; PIM1; AXL; KDR; IGF1R; AURKB;
Lyase	CA2; CA1; CA12; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Lysine demethylase	KDM4E;
Serine protease	F10;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	NFKB1;
Transferase	FUT7;
SLC superfamily of solute carriers	SLC1A1;
Unclassified	LMNA; FABP3; FABP4; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1B1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687

Showing 1 to 10 of 53 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.332E-09	5.696E-06	CA1, CA12, CA14, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	8.885E-09	1.358E-05	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.985E-08	4.523E-05	CA1, CA12, CA2, CA4, CA7
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	2.179E-07	1.335E-04	ALOX12, CA12, CA2, CA7, FABP3, FABP4, FFAR1, GRIK5, GRM1, MAPK1, MET, NOX4, NPSR1, NR1H4
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	1.386E-06	5.520E-04	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	1.714E-06	6.421E-04	GRIK3, GRM1, GRM8
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	3.305E-06	1.058E-03	ALOX12, AURKB, AXL, CDK1, FFAR4, IGF1R, KDR, LMNA, MMP9, NFKB1, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	7.671E-06	2.198E-03	ALOX12, ALOX15
BP	GO:0050896; response to stimulus	GO:0034614; cellular response to reactive oxygen species	1.266E-05	3.317E-03	AXL, CDK1, CYP1B1, MAPK1, MMP9
BP	GO:0009987; cellular process	GO:0097237; cellular response to toxic substance	2.110E-05	4.837E-03	AXL, CDK1, CYP1B1, KDR, NFKB1

Showing 1 to 10 of 23 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.518E-12	5.664E-10	CA12, CA1, CA2, CA4, CA7, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.169E-04	4.895E-03	HSD11B1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.012E-03	7.066E-03	HSD11B1, CYP1B1, CYP3A4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5.079E-08	2.725E-06	GRIA2, GRIK5, ADORA3, GRM8, GRIK3, GRIK1, TSHR, GRM1, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.974E-04	2.119E-03	GRIA2, MAPK1, NFKB1, TSHR, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	3.625E-04	3.647E-03	KDR, MAPK1, MET, NFKB1, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.053E-03	7.066E-03	MAPK1, MET, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	1.977E-11	1.592E-09	GRIA2, GRIK5, SLC1A1, GRM8, GRIK3, MAPK1, GRIK1, GRM1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	2.069E-05	3.701E-04	GRIA2, MAPK1, GRM1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.421E-04	1.835E-03	CDK1, MAPK1, CDC25B, IGF1R

Showing 1 to 10 of 25 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cornus officinalis

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities