CMAUP Plant Collective Molecular Activities

Plant Name: Asarum heterotropoides

Taxonomic Information:

Plant ID: NPO12468
Plant Latin Name: Asarum heterotropoides
Taxonomy Genus: Asarum
Taxonomy Family: Aristolochiaceae

Plant External Links:

NCBI TaxonomyDB: 366663
Plant-of-the-World-Online: n.a.

Used in Medicines:

Unknown.

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Small molecule receptor (family A GPCR)	ADORA3; ADRB1;
Enzyme_unclassified	RECQL; TDP1; ALOX12; HSD17B10; NOX4; POLB;
Voltage-gated calcium channel	CACNA1C;
Protein Kinase	EPHB4; IRAK1; MAPK10; MET; AXL; SLK; MAP4K4; FLT3; MKNK2; CDK1; MAPK1; MAPK14; ERBB2; SIK2; EGFR; PIM1; BLK; IRAK4; KDR; CHEK2; IGF1R; ERBB4; LCK; AURKB; FRK; HCK; LYN;
Lyase	CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	HIF1A; TP53; NFKB1;
Unclassified	LMNA; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP3A4; CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	EPHB4	Ephrin type-B receptor 4	P54760	CHEMBL5147
Protein Kinase	IRAK1	Interleukin-1 receptor-associated kinase 1	P51617	CHEMBL3357
Protein Kinase	MAPK10	c-Jun N-terminal kinase 3	P53779	CHEMBL2637
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	SLK	Serine/threonine-protein kinase 2	Q9H2G2	CHEMBL4202
Protein Kinase	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4	O95819	CHEMBL6166
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	MKNK2	MAP kinase signal-integrating kinase 2	Q9HBH9	CHEMBL4204
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	MAPK14	MAP kinase p38 alpha	Q16539	CHEMBL260
Protein Kinase	ERBB2	Receptor protein-tyrosine kinase erbB-2	P04626	CHEMBL1824
Protein Kinase	SIK2	Serine/threonine-protein kinase SIK2	Q9H0K1	CHEMBL5699
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	BLK	Tyrosine-protein kinase BLK	P51451	CHEMBL2250
Protein Kinase	IRAK4	Interleukin-1 receptor-associated kinase 4	Q9NWZ3	CHEMBL3778
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	CHEK2	Serine/threonine-protein kinase Chk2	O96017	CHEMBL2527
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	ERBB4	Receptor protein-tyrosine kinase erbB-4	Q15303	CHEMBL3009
Protein Kinase	LCK	Tyrosine-protein kinase LCK	P06239	CHEMBL258
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	FRK	Tyrosine-protein kinase FRK	P42685	CHEMBL4223
Protein Kinase	HCK	Tyrosine-protein kinase HCK	P08631	CHEMBL3234
Protein Kinase	LYN	Tyrosine-protein kinase Lyn	P07948	CHEMBL3905
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADRB1	Beta-1 adrenergic receptor	P08588	CHEMBL213
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Voltage-gated calcium channel	CACNA1C	Voltage-gated L-type calcium channel alpha-1C subunit	Q13936	CHEMBL1940

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	Unclassified;	GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity	1.311E-11	3.911E-09	EGFR, ERBB2, ERBB4, KDR, LYN
BP	GO:0050896; response to stimulus	GO:0031663; lipopolysaccharide-mediated signaling pathway	1.692E-08	2.879E-06	HCK, IRAK1, LYN, MAPK1, MAPK14
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	2.459E-08	3.967E-06	EGFR, ERBB2, LCK, MAPK14, MAPT, MET, TP53
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	1.409E-07	1.882E-05	AXL, EGFR, ERBB2, ERBB4, LCK, MET, NOX4
MF	GO:0003824; catalytic activity	GO:0004715; non-membrane spanning protein tyrosine kinase activity	2.249E-07	2.915E-05	BLK, FRK, HCK, LCK, LYN
MF	GO:0005488; binding	GO:0005102; receptor binding	2.281E-07	2.924E-05	ADRB1, BLK, EGFR, ERBB2, ERBB4, FLT3, FRK, HCK, HIF1A, IGF1R, IRAK4, KDR, LCK, LYN, MAPT, NR1H4, TP53
MF	GO:0003824; catalytic activity	GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity	8.304E-07	9.321E-05	EGFR, ERBB2, ERBB4, LCK, MET
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	1.285E-06	1.385E-04	BLK, FRK, HCK, LCK, LYN
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	3.537E-06	3.501E-04	CHEK2, CYP1B1, EGFR, FLT3, MAPK1, NFKB1, NOX4, RORC
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	4.647E-06	4.439E-04	AURKB, CDK1, CHEK2, MAPK1, MAPK14, MKNK2
BP	GO:0009987; cellular process	GO:0034605; cellular response to heat	5.928E-06	5.447E-04	IRAK1, LYN, MAPT, TP53
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.928E-06	5.447E-04	CYP19A1, CYP1B1, CYP3A4, NOX4
MF	Unclassified;	GO:0004707; MAP kinase activity	6.184E-06	5.658E-04	MAPK1, MAPK10, MAPK14
BP	GO:0008152; metabolic process	GO:0046854; phosphatidylinositol phosphorylation	6.224E-06	5.671E-04	EGFR, ERBB2, ERBB4, LCK, MET
MF	Unclassified;	GO:0004872; receptor activity	7.160E-06	6.363E-04	ADORA3, ADRB1, AXL, EGFR, EPHB4, ERBB2, ERBB4, FLT3, IGF1R, KDR, MET, NPSR1, NR1H4, RORC, TSHR
MF	Unclassified;	GO:0004708; MAP kinase kinase activity	7.715E-06	6.614E-04	MAPK1, MAPK10, MAPK14
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.715E-06	6.614E-04	CA12, CA4, CA7
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	8.408E-06	7.015E-04	EGFR, IGF1R, MAPK1, NFKB1, NOX4, NR1H4, TP53, TSHR
MF	GO:0005488; binding	GO:0042802; identical protein binding	1.265E-05	1.013E-03	CHEK2, EGFR, ERBB2, ERBB4, FLT3, IGF1R, IRAK1, KDR, LCK, MAPK1, MAPT, MET, NFKB1, SLK, TP53
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	1.744E-05	1.333E-03	CA7, CACNA1C, KDR, LCK, LYN, NPSR1
CC	GO:0032991; macromolecular complex	GO:0043235; receptor complex	2.068E-05	1.558E-03	EGFR, ERBB2, ERBB4, IGF1R, IRAK1, LYN, TSHR
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	2.603E-05	1.902E-03	AXL, CDK1, CYP1B1, EGFR, HIF1A, KDR, MAPK1, TP53
BP	GO:0009987; cellular process	GO:0010638; positive regulation of organelle organization	2.957E-05	2.098E-03	AURKB, HCK, HIF1A, KDR, MAPK1, MAPT, MET, NOX4, TP53
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.959E-05	2.098E-03	CYP19A1, CYP1B1, CYP3A4
BP	GO:0065007; biological regulation	GO:0000187; activation of MAPK activity	3.703E-05	2.560E-03	CDK1, IRAK1, MAPK1, MAPK10, MAPK14
MF	GO:0005488; binding	GO:0046982; protein heterodimerization activity	4.372E-05	2.949E-03	ADRB1, AXL, EGFR, ERBB2, HIF1A, IRAK1, NFKB1, TP53
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	4.806E-05	3.152E-03	AXL, CDK1, EGFR, FLT3
CC	GO:0044464; cell part	GO:0005737; cytoplasm	4.831E-05	3.159E-03	ALOX12, CACNA1C, CYP3A4, EGFR, HIF1A, HSD17B10, IRAK1, IRAK4, LYN, MAP4K4, MAPK1, MAPK10, MAPK14, MAPT, MKNK2, NFKB1, NPSR1, PIM1, POLB, RECQL, SIK2, SLK, TDP1, TP53
BP	GO:0050896; response to stimulus	GO:0071480; cellular response to gamma radiation	4.850E-05	3.162E-03	CHEK2, NOX4, TP53
BP	GO:0008152; metabolic process	GO:0045893; positive regulation of transcription, DNA-templated	5.678E-05	3.647E-03	CHEK2, EGFR, ERBB2, ERBB4, HIF1A, IRAK1, MAPK1, MAPK14, MET, NFKB1, NR1H4, RORC, TP53
MF	GO:0005488; binding	GO:0043548; phosphatidylinositol 3-kinase binding	6.036E-05	3.843E-03	AXL, IGF1R, LCK
BP	GO:0050896; response to stimulus	GO:0050727; regulation of inflammatory response	6.758E-05	4.213E-03	CYP19A1, EGFR, HCK, LYN, MAPK14, NFKB1, NR1H4
BP	GO:0009987; cellular process	GO:0070372; regulation of ERK1 and ERK2 cascade	8.131E-05	4.970E-03	EGFR, ERBB2, ERBB4, KDR, LYN, NOX4
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	8.148E-05	4.970E-03	HIF1A, KDR, MAPT
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	8.315E-05	5.057E-03	ADORA3, CYP1B1, ERBB2, ERBB4, FRK, LMNA, LYN, NOX4, TP53
BP	GO:0009987; cellular process	GO:0045595; regulation of cell differentiation	9.358E-05	5.596E-03	AXL, CDK1, EGFR, ERBB2, ERBB4, HIF1A, KDR, LYN, MAP4K4, MAPK1, MAPK14, MAPT, NFKB1, RORC
MF	GO:0005488; binding	GO:0001784; phosphotyrosine residue binding	1.069E-04	6.176E-03	HCK, LCK, MAPK1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.164E-04	6.637E-03	CA12, CA4, CA7
CC	GO:0016020; membrane	GO:0045121; membrane raft	1.175E-04	6.678E-03	EGFR, HCK, KDR, LCK, LYN, MAPK1
BP	GO:0065007; biological regulation	GO:0007190; activation of adenylate cyclase activity	1.265E-04	7.153E-03	ADORA3, ADRB1, TSHR
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.287E-04	7.260E-03	CA4, EGFR, ERBB2, ERBB4, TSHR
BP	GO:0032501; multicellular organismal process	GO:0007435; salivary gland morphogenesis	1.423E-04	7.987E-03	EGFR, POLB
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	1.423E-04	7.987E-03	FLT3, KDR
MF	GO:0005488; binding	GO:0008134; transcription factor binding	1.444E-04	8.073E-03	FLT3, HIF1A, MAPK1, MAPK14, NFKB1, NR1H4, PIM1, TP53
BP	GO:0009987; cellular process	GO:0038128; ERBB2 signaling pathway	1.482E-04	8.169E-03	EGFR, ERBB2, ERBB4
BP	GO:0009987; cellular process	GO:0000226; microtubule cytoskeleton organization	1.569E-04	8.607E-03	AURKB, CDK1, CHEK2, LMNA, MAPT, SLK
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	1.631E-04	8.881E-03	HIF1A, IRAK1, LMNA, TP53
BP	GO:0009987; cellular process	GO:0043065; positive regulation of apoptotic process	1.774E-04	9.563E-03	CHEK2, CYP1B1, ERBB4, LCK, LYN, MAPT, NOX4, TP53
MF	GO:0005488; binding	GO:0005524; ATP binding	9.621E-20	2.328E-16	AURKB, AXL, BLK, CDK1, CHEK2, EGFR, EPHB4, ERBB2, ERBB4, FLT3, FRK, HCK, IGF1R, IRAK1, IRAK4, KDR, LCK, LYN, MAP4K4, MAPK1, MAPK10, MAPK14, MET, MKNK2, PIM1, RECQL, SIK2, SLK, TP53
BP	GO:0008152; metabolic process	GO:0038083; peptidyl-tyrosine autophosphorylation	3.737E-15	2.729E-12	BLK, EGFR, ERBB4, FRK, HCK, IGF1R, KDR, LCK, LYN

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	8.268E-11	1.298E-08	ERBB4, ERBB2, KDR, MAPK1, MAPK14, TP53, HIF1A, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	7.685E-10	4.022E-08	MAPK10, MKNK2, MAPK1, MAPT, CACNA1C, MAPK14, TP53, EGFR, NFKB1, MAP4K4
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.535E-10	2.775E-08	FLT3, ERBB2, MAPK1, TP53, MET, HIF1A, EGFR
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.641E-08	4.896E-07	MAPK10, ERBB2, MAPK1, TP53, EGFR, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	7.513E-09	2.949E-07	MKNK2, ERBB2, MAPK1, HIF1A, EGFR, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.247E-08	9.154E-07	MAPK10, FLT3, ERBB2, MAPK1, HIF1A, MET, TP53, EGFR, NFKB1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1.969E-08	4.896E-07	LYN, MAPK10, MAPK14, MET, EGFR, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	2.183E-08	4.896E-07	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.004E-07	1.576E-06	ERBB2, MAPK1, TP53, EGFR, NFKB1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.573E-08	7.013E-07	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	2.851E-07	3.731E-06	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	2.546E-07	3.634E-06	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	5.382E-07	6.499E-06	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05169	Epstein-Barr virus infection	7.678E-07	7.272E-06	MAPK10, LYN, IRAK1, CDK1, MAPK14, TP53, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	7.678E-07	7.272E-06	MAPK10, ERBB2, KDR, MAPK1, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	7.874E-07	7.272E-06	ERBB2, PIM1, CYP1B1, MAPK1, TP53, MET, EGFR, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	5.943E-07	6.664E-06	MAPK10, ADORA3, MAPK1, MAPK14, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.675E-06	1.195E-05	MAPK10, KDR, MAPK1, MET, EGFR, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.011E-06	8.819E-06	MAPK1, TP53, MET, EGFR, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.088E-06	8.989E-06	MAPK10, MAPK1, MAPK14, TP53, EGFR, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.162E-06	9.121E-06	IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.244E-06	9.298E-06	ERBB2, MAPK1, MET, EGFR, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	3.475E-06	2.224E-05	MAPK10, MAPK1, CACNA1C, MAPK14, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	2.783E-06	1.899E-05	MAPK10, ERBB4, ERBB2, MAPK1, EGFR
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5.807E-06	3.195E-05	MAPK10, PIM1, MAPK1, MAPK14, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5.008E-06	2.912E-05	MAPK10, CDK1, MAPK1, MAPK14, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05152	Tuberculosis	5.901E-06	3.195E-05	MAPK10, IRAK1, MAPK1, IRAK4, MAPK14, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	3.869E-06	2.336E-05	LYN, IRAK1, LCK, IRAK4, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.116E-05	5.478E-05	MAPK10, MAPK1, ADRB1, CACNA1C, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.322E-05	5.847E-05	LYN, POLB, CDK1, MAPK1, TP53, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.557E-05	6.606E-05	KDR, MAPK1, MAPK14, MET, EGFR, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.394E-05	8.948E-05	KDR, MAPK1, TP53, MET, EGFR, NFKB1, IGF1R
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	2.137E-05	8.668E-05	MAPK10, LCK, MAPK1, MAPK14, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	2.216E-05	8.668E-05	MAPK10, MAPK1, MAPK14, EGFR, IGF1R
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.837E-05	1.012E-04	MAPK10, LMNA, MAPK1, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	9.275E-06	4.854E-05	ERBB2, MAPK1, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	3.542E-06	2.224E-05	ERBB2, MAPK1, TP53, EGFR
09140 Cellular Processes	09141 Transport and catabolism	hsa04144	Endocytosis	4.919E-05	1.679E-04	ERBB4, KDR, ADRB1, MET, EGFR, IGF1R
09160 Human Diseases	09161 Cancers	hsa05223	Non-small cell lung cancer	1.249E-05	5.847E-05	ERBB2, MAPK1, TP53, EGFR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.341E-05	5.847E-05	FLT3, PIM1, MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05164	Influenza A	8.215E-05	2.632E-04	MAPK10, MAPK1, IRAK4, MAPK14, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	9.383E-05	2.888E-04	ERBB4, ERBB2, ADRB1, CACNA1C, EGFR
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	2.264E-05	8.668E-05	MAPK1, TP53, EGFR, IGF1R
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	2.707E-05	9.885E-05	LYN, MAPK10, MAPK1, MAPK14
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	9.383E-05	2.888E-04	FLT3, TP53, MET, NFKB1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	3.395E-05	1.184E-04	MAPK10, MAPK1, MAPK14, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.341E-05	5.847E-05	MAPK10, MAPK1, MAPK14, NFKB1
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	1.276E-04	3.780E-04	MAPK10, MAPK1, HIF1A, EGFR
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.774E-04	5.064E-04	MAPK10, MAPK1, MAPK14, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.276E-04	3.780E-04	MAPK10, MAPK1, CACNA1C, MAPK14
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	7.467E-05	2.442E-04	CDK1, MAPK1, ADRB1, EGFR
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	1.429E-04	4.154E-04	LCK, MAPK1, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	6.825E-05	2.280E-04	MAPK10, MAPK1, MAPK14, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	2.722E-04	7.499E-04	SLK, CDK1, MAPK1, IGF1R
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	4.974E-04	1.259E-03	POLB, LCK, CHEK2, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	2.264E-05	8.668E-05	MAPK10, MAPK1, MAPK14, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.990E-04	1.062E-03	IRAK1, IRAK4, TP53, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	5.217E-04	1.280E-03	MAPK10, MAPK1, TP53, NFKB1
09150 Organismal Systems	09153 Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5.492E-04	1.306E-03	MAPK1, ADRB1, CACNA1C, MAPK14
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	8.632E-04	1.882E-03	ADORA3, MAPK1, ADRB1, CACNA1C
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	8.826E-04	1.898E-03	MAPK1, CACNA1C, MAPT, HSD17B10
09160 Human Diseases	09167 Infectious diseases	hsa05168	Herpes simplex infection	1.261E-03	2.676E-03	MAPK10, CDK1, TP53, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04062	Chemokine signaling pathway	1.312E-03	2.747E-03	LYN, HCK, MAPK1, NFKB1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4.620E-03	8.243E-03	FLT3, KDR, MET, EGFR
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	3.726E-03	6.964E-03	LYN, MAPK1, MAPK14
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2.003E-03	3.982E-03	MAPK10, ALOX12, MAPK14
09150 Organismal Systems	09151 Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1.725E-03	3.516E-03	LYN, HCK, MAPK1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	3.392E-03	6.417E-03	MAPK1, TP53, HIF1A
09150 Organismal Systems	09149 Aging	hsa04211	Longevity regulating pathway - mammal	1.778E-03	3.579E-03	TP53, NFKB1, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5.689E-03	9.924E-03	MAPK1, MAPK14, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.928E-03	5.606E-03	MAPK1, ALOX12, CACNA1C
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	5.362E-03	9.459E-03	MAPK10, MKNK2, MAPK1
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	3.900E-03	7.203E-03	CHEK2, CDK1, TP53
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	4.356E-03	7.861E-03	MAPK10, CACNA1C, MAPK14
09150 Organismal Systems	09158 Development	hsa04360	Axon guidance	4.170E-03	7.612E-03	MAPK1, MET, EPHB4
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	8.567E-04	1.882E-03	LYN, MAPK1, NFKB1
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.570E-03	3.243E-03	LMNA, ADRB1, CACNA1C
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	8.567E-04	1.882E-03	MAPK1, TP53, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	4.825E-04	1.242E-03	LYN, MAPK1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	5.065E-04	1.262E-03	KDR, MAPK1, MAPK14
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	6.383E-04	1.496E-03	MAPK1, MET, HIF1A
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	5.313E-04	1.283E-03	MAPK10, MAPK1, TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	7.269E-04	1.678E-03	CHEK2, CDK1, TP53
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	7.581E-04	1.725E-03	MAPK10, MAPK14, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.366E-04	1.142E-03	CYP1B1, CYP3A4, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.814E-04	7.616E-04	CYP1B1, CYP19A1, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	2.492E-04	6.986E-04	MAPK10, MAPK1, CACNA1C
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.477E-03	4.801E-03	MAPK1, TP53
Unclassified	Unclassified	hsa04320	Dorso-ventral axis formation	2.148E-03	4.216E-03	MAPK1, EGFR
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.036E-05	5.246E-05	CA12, CA4, CA7

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	Acute supraventricular tachycardia	I47.1	ADRB1;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	ADRB1;
P00-P96: Certain conditions originating in the perinatal period	Central nervous system injury	P11.9	MAPK10;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3; EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
NA: NA	Cardiogenic shock	NA	ADRB1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
C00-D49: Neoplasms	CLL	NA	FLT3;
I00-I99: Diseases of the circulatory system	Circulatory disorders	I00-I99	ADRB1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; EGFR; ERBB2; CYP19A1;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	ERBB2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MAPK14;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR; LYN;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	MAPK14;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; ADORA3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADRB1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Bone disease	M00-M99	LYN;
C00-D49: Neoplasms	Brain cancer	C71, D33	EGFR;
I00-I99: Diseases of the circulatory system	Heart arrhythmia	I47-I49	ADRB1; CACNA1C;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MAPK14; IRAK4;
NA: NA	Angina	NA	ADRB1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Bladder cancer	C67	EGFR; ERBB2; CYP19A1;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
NA: NA	Acute respiratory distress syndrome	NA	MAPK14;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	ADRB1; CACNA1C;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADRB1;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	CACNA1C;
C00-D49: Neoplasms	HER2-positive urogenital cancer	NA	ERBB2;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; ERBB4; IGF1R; KDR; NFKB1; FLT3; CHEK2; HIF1A; ADORA3; EPHB4; MAPK1; MAPK14; EGFR; ERBB2; TP53;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; EGFR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; EGFR;
NA: NA	Rheumatold arthritis	NA	MAPK14;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MAPK14;
H00-H59: Diseases of the eye and adnexa	Retinal venous occlusion	H34.8	ERBB2;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
I00-I99: Diseases of the circulatory system	Ventricular fibrillation	I49.01	ADRB1;
NA: NA	Ventricular premature beats	NA	ADRB1;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR; EGFR;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	ADRB1;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADRB1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
I00-I99: Diseases of the circulatory system	Maintenance of normal sinus rhythm	I46-I49	ADRB1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MAPK14;
C00-D49: Neoplasms	Melanoma	C43	KDR; EGFR;
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; ERBB4; IGF1R; KDR; FLT3; CHEK2; HIF1A; MAPK1; EGFR; ERBB2; TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	ADRB1;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRB1;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; EGFR; TP53;
C00-D49: Neoplasms	Late-stage non-small cell lung cancer	C33-C34	EPHB4;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Lung cancer	C33-C34	EGFR;
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; MAPK14; EGFR;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3; EGFR; ERBB2;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
J00-J99: Diseases of the respiratory system	Asthma	J45	ERBB2;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; EGFR; ERBB2;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	LCK;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; ERBB2;
C00-D49: Neoplasms	Glioma	C71	KDR; EGFR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3; ADRB1;
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR;
C00-D49: Neoplasms	Non-hodgkin's lymphoma	C85	ERBB2;
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR; ERBB2;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
NA: NA	Neurogenic shock	NA	ADRB1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	ADRB1; MAPK14;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRB1;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
NA: NA	Inflammatory diseases	NA	MAPK14;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADRB1;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; ADRB1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ADRB1;
C00-D49: Neoplasms	Gastric cancer	C16	KDR; EGFR; ERBB2;
NA: NA	Metastatic hormone refractory prostate cancer	NA	LYN;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	ADRB1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	MAPK14;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R;
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	MAPK14;
C00-D49: Neoplasms	Urethral cancer	NA	EGFR;
H00-H59: Diseases of the eye and adnexa	Chronic open-angle glaucoma	H40	ADRB1;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; EGFR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; EGFR; ERBB2; TP53;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; ERBB4; IGF1R; KDR; AXL; EGFR;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR;
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	ADRB1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	MAPK14;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases