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Plant Name: Asarum heterotropoides




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Peptide receptor (family A GPCR)
NPSR1; TSHR; CCR2; CXCR1;
Small molecule receptor (family A GPCR)
ADORA3; ADORA1; ADRB1; GPBAR1; DRD4;
Enzyme_unclassified
ALPI; RECQL; PLA2G1B; TDP1; BLM; GLA; PIK3R1; GLO1; CYP2J2; HSD11B1; MPO; HSD17B1; AKR1B1; HSD17B10; ALOX15; HSD17B2; ALOX12; AKR1B10; NOX4; PYGL; POLB;
Protein Phosphatase
PTPRF; PTPN1; PTPN2; ACP1;
Hydrolase
ACHE; GAA;
Voltage-gated calcium channel
CACNA1D; CACNA1C;
Transient receptor potential channel
TRPA1;
Potassium channels
KCNA5;
Protein Kinase
PKN1; MET; BLK; MAP4K4; CSNK2A1; AKT1; DAPK1; AXL; NEK2; FLT3; NEK6; ABL1; HIPK4; MAP4K5; CAMK2B; BRSK1; IRAK4; SRC; IGF1R; SLK; PTK2; ERBB4; AURKB; LYN; CDK2; FLT4; EPHB4; GSK3B; CAMK2D; CAMK2G; PIM3; KDR; CHEK2; MAPK9; MKNK2; CDK1; MAPK1; MAPK14; SIK2; EGFR; ERBB2; PIM1; NUAK1; PHKG2; LCK; MAPK10; FRK; HCK; PRKD2; PRKD3; MINK1; IRAK1; LIMK1; RET; MYLK; ATM; ALK; CSNK1D;
Lyase
CA12; CA7; CA5A; CA3; CA14; CA5B; CA1; CA9; CA4; CA6; CA2;
Nuclear hormone receptor subfamily 1 group F
RORC;
Nuclear hormone receptor subfamily 1 group H
NR1H4;
Oxidoreductase
HMGCR; MAOA; ALOX5; XDH;
Lysine demethylase
KDM4E;
Metallo protease
MMP13; MMP3; MMP2; MMP9;
Aspartic protease
BACE1;
Transcription Factor
STAT6; HIF1A; NFKB1; TP53;
ATP-binding cassette
ABCC1; ABCG2;
Unclassified
LMNA; MAPT; THPO;
Methyl-lysine/arginine binding protein
SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP19A1; CYP1A2; CYP2C19; CYP2C9; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 P10632 CHEMBL3721
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Enzyme_unclassified PIK3R1 PI3-kinase p85-alpha subunit P27986 CHEMBL2506
Enzyme_unclassified GLO1 Glyoxalase I Q04760 CHEMBL2424
Enzyme_unclassified CYP2J2 Cytochrome P450 2J2 P51589 CHEMBL3491
Enzyme_unclassified HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 P28845 CHEMBL4235
Enzyme_unclassified MPO Myeloperoxidase P05164 CHEMBL2439
Enzyme_unclassified HSD17B1 Estradiol 17-beta-dehydrogenase 1 P14061 CHEMBL3181
Enzyme_unclassified AKR1B1 Aldose reductase P15121 CHEMBL1900
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified AKR1B10 Aldo-keto reductase family 1 member B10 O60218 CHEMBL5983
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified PYGL Liver glycogen phosphorylase P06737 CHEMBL2568
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Enzyme_unclassified ALPI Intestinal alkaline phosphatase P09923 CHEMBL5573
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified PLA2G1B Phospholipase A2 group 1B P04054 CHEMBL4426
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified BLM Bloom syndrome protein P54132 CHEMBL1293237
Enzyme_unclassified GLA Alpha-galactosidase A P06280 CHEMBL2524
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Hydrolase GAA Lysosomal alpha-glucosidase P10253 CHEMBL2608
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA5A Carbonic anhydrase VA P35218 CHEMBL4789
Lyase CA3 Carbonic anhydrase III P07451 CHEMBL2885
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA5B Carbonic anhydrase VB Q9Y2D0 CHEMBL3969
Lyase CA1 Carbonic anhydrase I P00915 CHEMBL261
Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lyase CA6 Carbonic anhydrase VI P23280 CHEMBL3025
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP13 Matrix metalloproteinase 13 P45452 CHEMBL280
Metallo protease MMP3 Matrix metalloproteinase 3 P08254 CHEMBL283
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Methyl-lysine/arginine binding protein SMN1;SMN2 Survival motor neuron protein Q16637 CHEMBL1293232
Nuclear hormone receptor subfamily 1 group F RORC Nuclear receptor ROR-gamma P51449 CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H NR1H4 Bile acid receptor FXR Q96RI1 CHEMBL2047
Oxidoreductase HMGCR HMG-CoA reductase P04035 CHEMBL402
Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Oxidoreductase ALOX5 Arachidonate 5-lipoxygenase P09917 CHEMBL215
Oxidoreductase XDH Xanthine dehydrogenase P47989 CHEMBL1929
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Peptide receptor (family A GPCR) CCR2 C-C chemokine receptor type 2 P41597 CHEMBL4015
Peptide receptor (family A GPCR) CXCR1 Interleukin-8 receptor A P25024 CHEMBL4029
Potassium channels KCNA5 Voltage-gated potassium channel subunit Kv1.5 P22460 CHEMBL4306
Protein Kinase MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 O95819 CHEMBL6166
Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Protein Kinase AKT1 Serine/threonine-protein kinase AKT P31749 CHEMBL4282
Protein Kinase DAPK1 Death-associated protein kinase 1 P53355 CHEMBL2558
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase NEK2 Serine/threonine-protein kinase NEK2 P51955 CHEMBL3835
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase NEK6 Serine/threonine-protein kinase NEK6 Q9HC98 CHEMBL4309
Protein Kinase ABL1 Tyrosine-protein kinase ABL P00519 CHEMBL1862
Protein Kinase HIPK4 Homeodomain-interacting protein kinase 4 Q8NE63 CHEMBL1075167
Protein Kinase MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 Q9Y4K4 CHEMBL4852
Protein Kinase CAMK2B CaM kinase II beta Q13554 CHEMBL4121
Protein Kinase BRSK1 BR serine/threonine-protein kinase 1 Q8TDC3 CHEMBL5650
Protein Kinase IRAK4 Interleukin-1 receptor-associated kinase 4 Q9NWZ3 CHEMBL3778
Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase SLK Serine/threonine-protein kinase 2 Q9H2G2 CHEMBL4202
Protein Kinase PTK2 Focal adhesion kinase 1 Q05397 CHEMBL2695
Protein Kinase ERBB4 Receptor protein-tyrosine kinase erbB-4 Q15303 CHEMBL3009
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Protein Kinase LYN Tyrosine-protein kinase Lyn P07948 CHEMBL3905
Protein Kinase CDK2 Cyclin-dependent kinase 2 P24941 CHEMBL301
Protein Kinase FLT4 Vascular endothelial growth factor receptor 3 P35916 CHEMBL1955
Protein Kinase EPHB4 Ephrin type-B receptor 4 P54760 CHEMBL5147
Protein Kinase GSK3B Glycogen synthase kinase-3 beta P49841 CHEMBL262
Protein Kinase CAMK2D CaM kinase II delta Q13557 CHEMBL2801
Protein Kinase CAMK2G CaM kinase II gamma Q13555 CHEMBL3829
Protein Kinase PIM3 Serine/threonine-protein kinase PIM3 Q86V86 CHEMBL5407
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase CHEK2 Serine/threonine-protein kinase Chk2 O96017 CHEMBL2527
Protein Kinase MAPK9 c-Jun N-terminal kinase 2 P45984 CHEMBL4179
Protein Kinase MKNK2 MAP kinase signal-integrating kinase 2 Q9HBH9 CHEMBL4204
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Protein Kinase MAPK14 MAP kinase p38 alpha Q16539 CHEMBL260
Protein Kinase SIK2 Serine/threonine-protein kinase SIK2 Q9H0K1 CHEMBL5699
Protein Kinase EGFR Epidermal growth factor receptor erbB1 P00533 CHEMBL203
Protein Kinase ERBB2 Receptor protein-tyrosine kinase erbB-2 P04626 CHEMBL1824
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 O60285 CHEMBL5784
Protein Kinase PHKG2 Phosphorylase kinase gamma subunit 2 P15735 CHEMBL2349
Protein Kinase LCK Tyrosine-protein kinase LCK P06239 CHEMBL258
Protein Kinase MAPK10 c-Jun N-terminal kinase 3 P53779 CHEMBL2637
Protein Kinase FRK Tyrosine-protein kinase FRK P42685 CHEMBL4223
Protein Kinase HCK Tyrosine-protein kinase HCK P08631 CHEMBL3234
Protein Kinase PRKD2 Serine/threonine-protein kinase D2 Q9BZL6 CHEMBL4900
Protein Kinase PRKD3 Protein kinase C nu O94806 CHEMBL2595
Protein Kinase MINK1 Misshapen-like kinase 1 Q8N4C8 CHEMBL5518
Protein Kinase IRAK1 Interleukin-1 receptor-associated kinase 1 P51617 CHEMBL3357
Protein Kinase LIMK1 LIM domain kinase 1 P53667 CHEMBL3836
Protein Kinase RET Tyrosine-protein kinase receptor RET P07949 CHEMBL2041
Protein Kinase MYLK Myosin light chain kinase, smooth muscle Q15746 CHEMBL2428
Protein Kinase ATM Serine-protein kinase ATM Q13315 CHEMBL3797
Protein Kinase ALK ALK tyrosine kinase receptor Q9UM73 CHEMBL4247
Protein Kinase CSNK1D Casein kinase I delta P48730 CHEMBL2828
Protein Kinase PKN1 Protein kinase N1 Q16512 CHEMBL3384
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase BLK Tyrosine-protein kinase BLK P51451 CHEMBL2250
Protein Phosphatase PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) P10586 CHEMBL3521
Protein Phosphatase PTPN1 Protein-tyrosine phosphatase 1B P18031 CHEMBL335
Protein Phosphatase PTPN2 T-cell protein-tyrosine phosphatase P17706 CHEMBL3807
Protein Phosphatase ACP1 Low molecular weight phosphotyrosine protein phosphatase P24666 CHEMBL4903
Small molecule receptor (family A GPCR) ADORA3 Adenosine A3 receptor P0DMS8 CHEMBL256
Small molecule receptor (family A GPCR) ADORA1 Adenosine A1 receptor P30542 CHEMBL226
Small molecule receptor (family A GPCR) ADRB1 Beta-1 adrenergic receptor P08588 CHEMBL213
Small molecule receptor (family A GPCR) GPBAR1 G-protein coupled bile acid receptor 1 Q8TDU6 CHEMBL5409
Small molecule receptor (family A GPCR) DRD4 Dopamine D4 receptor P21917 CHEMBL219
Transcription Factor STAT6 Signal transducer and activator of transcription 6 P42226 CHEMBL5401
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Transcription Factor TP53 Cellular tumor antigen p53 P04637 CHEMBL4096
Transient receptor potential channel TRPA1 Transient receptor potential cation channel subfamily A member 1 O75762 CHEMBL6007
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified MAPT Microtubule-associated protein tau P10636 CHEMBL1293224
Unclassified THPO Thrombopoietin P40225 CHEMBL1293256
Voltage-gated calcium channel CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Q01668 CHEMBL4138
Voltage-gated calcium channel CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Q13936 CHEMBL1940
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 2.669E-11 3.609E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
MF GO:0005488; binding GO:0019825; oxygen binding 3.023E-11 4.039E-09 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, NOX4
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 9.650E-11 1.236E-08 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2J2
MF GO:0005488; binding GO:0020037; heme binding 1.511E-10 1.901E-08 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2J2, CYP3A4, MPO, NOX4, SRC
MF GO:0005488; binding GO:0005506; iron ion binding 1.532E-10 1.917E-08 ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2J2, CYP3A4, XDH
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 2.010E-10 2.459E-08 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2J2, CYP3A4
CC GO:0044464; cell part GO:0005829; cytosol 1.737E-09 1.827E-07 ABL1, ACP1, AKR1B1, AKR1B10, AKT1, ALOX12, ALOX15, ALOX5, AURKB, BLK, BLM, CA1, CA2, CA3, CA7, CAMK2B, CAMK2D, CAMK2G, CCR2, CDK1, CDK2, CSNK1D, CSNK2A1, EPHB4, ERBB2, ERBB4, FLT3, FRK, GLO1, GSK3B, HCK, HIF1A, HSD17B1, IRAK1, IRAK4, LCK, LIMK1, LMNA, LYN, MAPK1, MAPK10, MAPK14, MAPK9, MAPT, MINK1, MYLK, NEK2, NEK6, NFKB1, PHKG2, PIK3R1, PIM1, PIM3, PKN1, PLA2G1B, PRKD2, PRKD3, PTK2, PTPN1, PTPN2, PYGL, RET, SMN1, SMN2, SRC, STAT6, TP53, XDH
MF Unclassified; GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity 2.292E-09 2.365E-07 EGFR, ERBB2, ERBB4, KDR, LYN
CC GO:0044464; cell part GO:0031234; extrinsic component of cytoplasmic side of plasma membrane 2.461E-09 2.516E-07 ABL1, ALOX15, BLK, FRK, HCK, LCK, LYN, PTK2, SRC
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 2.644E-09 2.677E-07 CYP1A2, CYP2C8, CYP2C9, CYP3A4
MF GO:0003824; catalytic activity GO:0004715; non-membrane spanning protein tyrosine kinase activity 3.048E-09 3.031E-07 ABL1, BLK, FRK, HCK, LCK, LYN, PTK2, SRC
BP Unclassified; GO:2000021; regulation of ion homeostasis 3.887E-09 3.778E-07 ABL1, ADORA1, CA2, CA7, CACNA1C, CAMK2D, KDR, LCK, LYN, NPSR1, PLA2G1B, SRC, TRPA1
BP Unclassified; GO:0032846; positive regulation of homeostatic process 1.056E-08 9.620E-07 ABL1, ATM, AURKB, CA2, CA7, EGFR, HIF1A, MAPK1, MAPK14, NEK2, NPSR1, NR1H4, PLA2G1B
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 1.414E-08 1.248E-06 AXL, EGFR, ERBB2, ERBB4, LCK, MET, NOX4, PIK3R1, PTK2, SRC, THPO
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 1.415E-08 1.248E-06 CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 3.921E-08 3.271E-06 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0016572; histone phosphorylation 4.301E-08 3.547E-06 ATM, AURKB, CDK1, CDK2, HIPK4, PKN1
BP GO:0009987; cellular process GO:1901796; regulation of signal transduction by p53 class mediator 6.444E-08 5.197E-06 AKT1, ATM, AURKB, BLM, CDK2, CHEK2, CSNK2A1, HIPK4, MAPK14, NUAK1, TP53
BP GO:0008283; cell proliferation GO:0048661; positive regulation of smooth muscle cell proliferation 7.753E-08 6.117E-06 AKR1B1, AKT1, EGFR, HMGCR, IRAK1, IRAK4, MMP2, MMP9
BP GO:0050896; response to stimulus GO:0031663; lipopolysaccharide-mediated signaling pathway 8.256E-08 6.444E-06 AKT1, HCK, IRAK1, LYN, MAPK1, MAPK14
BP GO:0009987; cellular process GO:0071276; cellular response to cadmium ion 8.256E-08 6.444E-06 AKT1, CYP1A2, EGFR, MAPK1, MAPK9, MMP9
BP GO:0009987; cellular process GO:0070374; positive regulation of ERK1 and ERK2 cascade 2.026E-07 1.490E-05 ABL1, ALOX15, EGFR, ERBB4, FLT4, HMGCR, KDR, NOX4, PRKD2, SRC, THPO
MF GO:0005488; binding GO:0008270; zinc ion binding 4.112E-07 2.852E-05 ALPI, BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP13, MMP2, MMP3, MMP9, NR1H4, PTPN1, RORC, TP53
BP GO:0032501; multicellular organismal process GO:0043536; positive regulation of blood vessel endothelial cell migration 7.326E-07 4.762E-05 ABL1, AKT1, HIF1A, KDR, MAPK14, PRKD2
BP GO:0048511; rhythmic process GO:0048511; rhythmic process 1.108E-06 6.809E-05 ATM, AXL, CSNK1D, CSNK2A1, DRD4, EGFR, GSK3B, MAPK10, MAPK9, RORC, SRC, TP53
MF GO:0005488; binding GO:0042803; protein homodimerization activity 1.204E-06 7.320E-05 ABCG2, ACHE, AKT1, BLM, CAMK2B, CAMK2D, CAMK2G, CCR2, CHEK2, ERBB4, FLT3, FLT4, GLA, HMGCR, IRAK1, MAPT, NFKB1, PYGL, SLK, XDH
CC GO:0044464; cell part GO:0043005; neuron projection 1.204E-06 7.320E-05 ABL1, ADORA1, BACE1, CA2, CAMK2B, CAMK2D, CAMK2G, CCR2, CSNK1D, LIMK1, MAPK1, MAPK10, MAPK9, MAPT, MINK1, PTPRF, RET, SMN1, SMN2, SRC
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 1.251E-06 7.547E-05 CYP1A2, CYP2C8, CYP2C9, CYP3A4
BP GO:0050896; response to stimulus GO:0046626; regulation of insulin receptor signaling pathway 1.409E-06 8.405E-05 NR1H4, PIK3R1, PTPN1, PTPN2, SIK2, SRC
BP GO:0009987; cellular process GO:1900034; regulation of cellular response to heat 1.555E-06 9.199E-05 ATM, CAMK2B, CAMK2D, CAMK2G, GSK3B, MAPK1, MAPT
MF GO:0005488; binding GO:0051721; protein phosphatase 2A binding 1.600E-06 9.441E-05 AKT1, HMGCR, MAPT, PTPN1, TP53
BP GO:0009987; cellular process GO:0071407; cellular response to organic cyclic compound 1.700E-06 9.897E-05 ABL1, AKT1, BLM, CHEK2, CYP1A1, CYP1B1, EGFR, FLT3, MAPK1, NFKB1, NOX4, RORC, SRC
MF GO:0005488; binding GO:0005524; ATP binding 1.807E-34 3.382E-31 ABCC1, ABCG2, ABL1, AKT1, ALK, ATM, AURKB, AXL, BLK, BLM, BRSK1, CAMK2B, CAMK2D, CAMK2G, CDK1, CDK2, CHEK2, CSNK1D, CSNK2A1, DAPK1, EGFR, EPHB4, ERBB2, ERBB4, FLT3, FLT4, FRK, GSK3B, HCK, HIPK4, IGF1R, IRAK1, IRAK4, KDR, LCK, LIMK1, LYN, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK14, MAPK9, MET, MINK1, MKNK2, MYLK, NEK2, NEK6, NUAK1, PHKG2, PIM1, PIM3, PKN1, PRKD2, PRKD3, PTK2, PYGL, RECQL, RET, SIK2, SLK, SRC, TP53
MF GO:0003824; catalytic activity GO:0050321; tau-protein kinase activity 1.797E-06 1.033E-04 BRSK1, CSNK1D, GSK3B, PHKG2
BP GO:0008152; metabolic process GO:0006691; leukotriene metabolic process 2.718E-06 1.498E-04 ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B
CC GO:0043226; organelle GO:0005654; nucleoplasm 3.052E-06 1.670E-04 ABL1, AKR1B1, AKT1, ALOX5, ATM, AURKB, BLM, BRSK1, CAMK2B, CAMK2D, CAMK2G, CDK1, CDK2, CHEK2, CSNK1D, CSNK2A1, ERBB4, FRK, GSK3B, HCK, HIF1A, LMNA, MAPK1, MAPK10, MAPK14, MAPK9, NEK2, NEK6, NFKB1, NR1H4, NUAK1, PIM1, PKN1, POLB, PRKD2, PRKD3, PTPN2, RECQL, RORC, SMN1, SMN2, SRC, STAT6, TP53
MF GO:0003824; catalytic activity GO:0101020; estrogen 16-alpha-hydroxylase activity 3.687E-06 1.982E-04 CYP1A1, CYP2C8, CYP3A4
BP GO:0008152; metabolic process GO:2000379; positive regulation of reactive oxygen species metabolic process 4.090E-06 2.183E-04 AKT1, EGFR, MAPK14, MAPT, NOX4, TP53, XDH
BP GO:0009987; cellular process GO:0038096; Fc-gamma receptor signaling pathway involved in phagocytosis 4.811E-06 2.518E-04 ABL1, HCK, LIMK1, LYN, MAPK1, PIK3R1, PTK2, SRC
MF GO:0005488; binding GO:0001784; phosphotyrosine residue binding 5.074E-06 2.630E-04 ABL1, HCK, LCK, MAPK1, PIK3R1
BP GO:0009987; cellular process GO:0070301; cellular response to hydrogen peroxide 5.209E-06 2.681E-04 ABL1, AKR1B1, AXL, CDK1, CYP1B1, STAT6
MF GO:0003824; catalytic activity GO:0008392; arachidonic acid epoxygenase activity 5.847E-06 2.968E-04 CYP2C19, CYP2C8, CYP2C9, CYP2J2
MF GO:0003824; catalytic activity GO:0035173; histone kinase activity 5.847E-06 2.968E-04 AURKB, CDK1, CDK2, PKN1
BP GO:0048511; rhythmic process GO:0042752; regulation of circadian rhythm 7.218E-06 3.596E-04 ADORA1, CSNK1D, DRD4, MAPK10, MAPK9, RORC, TP53
BP GO:0008152; metabolic process GO:0002933; lipid hydroxylation 7.335E-06 3.630E-04 CYP1A1, CYP2C8, CYP3A4
MF GO:0003824; catalytic activity GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity 8.274E-06 4.058E-04 EGFR, ERBB2, ERBB4, LCK, MET, PIK3R1
CC GO:0016020; membrane GO:0016323; basolateral plasma membrane 8.692E-06 4.234E-04 ABCC1, ADORA1, CA2, CA4, CA9, EGFR, ERBB2, ERBB4, TSHR
BP GO:0009987; cellular process GO:0038128; ERBB2 signaling pathway 8.792E-06 4.273E-04 EGFR, ERBB2, ERBB4, PIK3R1, SRC
CC GO:0016020; membrane GO:0045121; membrane raft 9.724E-06 4.664E-04 BACE1, EGFR, HCK, KCNA5, KDR, LCK, LYN, MAPK1, RET, SRC, STAT6
BP GO:0009987; cellular process GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage 9.850E-06 4.704E-04 ABL1, ATM, CHEK2, PIK3R1, POLB, TP53
BP Unclassified; GO:0032845; negative regulation of homeostatic process 1.024E-05 4.856E-04 ADORA1, ATM, HMGCR, LCK, MAP4K4, PIM3, SRC, TRPA1
BP Unclassified; GO:0044236; multicellular organism metabolic process 1.212E-05 5.674E-04 ADRB1, HIF1A, MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP GO:0050896; response to stimulus GO:0009612; response to mechanical stimulus 1.271E-05 5.891E-04 AKT1, EGFR, KCNA5, MAPK14, MAPK9, MPO, NFKB1, SRC, TRPA1
MF GO:0060089; molecular transducer activity GO:0005021; vascular endothelial growth factor-activated receptor activity 1.277E-05 5.891E-04 FLT3, FLT4, KDR
MF GO:0098772; molecular function regulator GO:0005088; Ras guanyl-nucleotide exchange factor activity 1.400E-05 6.340E-04 ADRB1, CAMK2B, CAMK2D, CAMK2G, EGFR, ERBB2, ERBB4, MET, PTK2, RET
BP GO:0050896; response to stimulus GO:0055093; response to hyperoxia 1.438E-05 6.454E-04 CYP1A1, KCNA5, POLB, TP53
BP GO:0009987; cellular process GO:0030168; platelet activation 1.545E-05 6.907E-04 AKT1, AXL, LCK, LYN, MAPK1, PIK3R1, SRC
MF Unclassified; GO:0032403; protein complex binding 1.808E-05 7.986E-04 ABL1, ACHE, ADORA1, ATM, EGFR, FLT3, IGF1R, KDR, LCK, LYN, MMP13, MMP9, PIK3R1, PTPN1, PTPN2, PTPRF, SRC, TSHR
CC GO:0044464; cell part GO:0042995; cell projection 1.996E-05 8.746E-04 ABL1, ADORA1, AKR1B1, BACE1, CA2, CAMK2B, CAMK2D, CAMK2G, CCR2, CSNK1D, HCK, HIF1A, LIMK1, MAPK1, MAPK10, MAPK9, MAPT, MINK1, MYLK, PTK2, PTPRF, RET, SMN1, SMN2, SRC
BP GO:0009987; cellular process GO:0006975; DNA damage induced protein phosphorylation 2.032E-05 8.850E-04 ABL1, ATM, CHEK2
BP GO:0050896; response to stimulus GO:0061179; negative regulation of insulin secretion involved in cellular response to glucose stimulus 3.032E-05 1.272E-03 HMGCR, MAP4K4, PIM3
BP GO:0009987; cellular process GO:0000733; DNA strand renaturation 3.032E-05 1.272E-03 BLM, RECQL, TP53
MF GO:0005488; binding GO:0032052; bile acid binding 3.032E-05 1.272E-03 NR1H4, PLA2G1B, PYGL
BP GO:0008152; metabolic process GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation 3.853E-05 1.574E-03 ABL1, ADORA1, ERBB4, FLT3, LYN, PTPN1, SRC, TP53
BP GO:0009987; cellular process GO:0031334; positive regulation of protein complex assembly 3.934E-05 1.601E-03 ALOX15, GSK3B, HCK, MAPK9, MAPT, MET, MMP3, SRC, TP53
BP GO:0050896; response to stimulus GO:0071480; cellular response to gamma radiation 4.075E-05 1.637E-03 ATM, CHEK2, NOX4, TP53
MF GO:0003824; catalytic activity GO:0033764; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4.075E-05 1.637E-03 HSD11B1, HSD17B1, HSD17B10, HSD17B2
BP GO:0022610; biological adhesion GO:0051893; regulation of focal adhesion assembly 4.426E-05 1.749E-03 ABL1, KDR, PTK2, SLK, SRC
BP GO:0008152; metabolic process GO:0045740; positive regulation of DNA replication 4.840E-05 1.879E-03 CDK1, CDK2, EGFR, IGF1R, PLA2G1B
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 5.216E-05 2.003E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 5.216E-05 2.003E-03 ALOX12, ALOX15
MF GO:0005488; binding GO:0043548; phosphatidylinositol 3-kinase binding 5.454E-05 2.080E-03 AXL, IGF1R, LCK, PIK3R1
BP GO:0009987; cellular process GO:0050714; positive regulation of protein secretion 5.513E-05 2.094E-03 ABL1, ACHE, BLK, EGFR, HIF1A, MAPK14, NR1H4, PLA2G1B, SRC
BP GO:0008152; metabolic process GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity 6.257E-05 2.332E-03 FLT3, LYN, PTK2, SRC
BP GO:0009987; cellular process GO:0090399; replicative senescence 7.815E-05 2.841E-03 ATM, CHEK2, TP53
BP GO:0051179; localization GO:0042307; positive regulation of protein import into nucleus 7.930E-05 2.873E-03 CDK1, EGFR, ERBB4, MAPK1, MAPK14, PIK3R1
MF GO:0005488; binding GO:0051879; Hsp90 protein binding 8.119E-05 2.927E-03 CSNK2A1, HIF1A, KDR, MAPT
BP GO:0008152; metabolic process GO:0046854; phosphatidylinositol phosphorylation 8.392E-05 3.005E-03 EGFR, ERBB2, ERBB4, LCK, MET, PIK3R1
BP GO:0009987; cellular process GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 8.645E-05 3.081E-03 ATM, CDK1, CDK2, CHEK2, TP53
BP GO:0008152; metabolic process GO:0010907; positive regulation of glucose metabolic process 9.187E-05 3.242E-03 AKT1, PHKG2, PTPN2, SRC
MF Unclassified; GO:0099600; transmembrane receptor activity 1.001E-04 3.488E-03 ADORA1, ADORA3, ADRB1, ALK, AXL, CCR2, CXCR1, DRD4, EGFR, EPHB4, ERBB2, ERBB4, FLT3, FLT4, GPBAR1, IGF1R, KDR, MET, NPSR1, PTPRF, RET, TSHR
MF GO:0005488; binding GO:0008134; transcription factor binding 1.003E-04 3.488E-03 FLT3, GSK3B, HIF1A, MAPK1, MAPK14, MAPK9, NEK6, NFKB1, NR1H4, PIK3R1, PIM1, PKN1, SRC, TP53
BP GO:0065007; biological regulation GO:0051881; regulation of mitochondrial membrane potential 1.007E-04 3.493E-03 ABL1, AKT1, KDR, MAPT, SRC
BP GO:0008152; metabolic process GO:0006703; estrogen biosynthetic process 1.011E-04 3.493E-03 CYP19A1, HSD17B1, HSD17B2
BP GO:0009987; cellular process GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response 1.011E-04 3.493E-03 PIK3R1, PTPN1, PTPN2
BP GO:0065007; biological regulation GO:0032212; positive regulation of telomere maintenance via telomerase 1.035E-04 3.573E-03 ATM, AURKB, MAPK1, NEK2
BP GO:0009987; cellular process GO:0071456; cellular response to hypoxia 1.103E-04 3.777E-03 AKT1, HIF1A, IRAK1, LMNA, SRC, TP53
CC GO:0032991; macromolecular complex GO:0043235; receptor complex 1.222E-04 4.125E-03 ABCG2, EGFR, ERBB2, ERBB4, FLT4, IGF1R, IRAK1, LYN, RET, TSHR
BP GO:0065007; biological regulation GO:0043281; regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.310E-04 4.375E-03 AKT1, CSNK2A1, DAPK1, LCK, MAPT, MMP9, SRC, XDH
BP GO:0008152; metabolic process GO:0031331; positive regulation of cellular catabolic process 1.460E-04 4.833E-03 AKT1, ATM, CDK1, CSNK1D, DAPK1, GSK3B, HIF1A, KDR, PHKG2, PTK2, PTPN1
BP GO:0002376; immune system process GO:0001922; B-1 B cell homeostasis 1.557E-04 5.039E-03 ABL1, HIF1A
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.557E-04 5.039E-03 CA2, CA7
BP GO:0009987; cellular process GO:0038183; bile acid signaling pathway 1.557E-04 5.039E-03 GPBAR1, NR1H4
MF GO:0005488; binding GO:0002039; p53 binding 1.544E-04 5.039E-03 BLM, GSK3B, HIF1A, NUAK1, TP53
MF GO:0003824; catalytic activity GO:0070576; vitamin D 24-hydroxylase activity 1.557E-04 5.039E-03 CYP1A1, CYP3A4
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 1.557E-04 5.039E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 1.557E-04 5.039E-03 ALOX12, ALOX15
MF GO:0060089; molecular transducer activity GO:0038181; bile acid receptor activity 1.557E-04 5.039E-03 GPBAR1, NR1H4
BP GO:0050896; response to stimulus GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway 1.591E-04 5.101E-03 LYN, MAPK1, PTPN1
MF Unclassified; GO:0004708; MAP kinase kinase activity 1.591E-04 5.101E-03 MAPK1, MAPK10, MAPK14
BP GO:0065007; biological regulation GO:0042593; glucose homeostasis 1.613E-04 5.142E-03 AKT1, HIF1A, NOX4, NR1H4, PIK3R1, PTPN2, PYGL
BP Unclassified; GO:0044243; multicellular organismal catabolic process 1.883E-04 5.882E-03 MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 1.947E-04 6.049E-03 ALOX12, ALOX15, ALOX5
MF GO:0003824; catalytic activity GO:0004697; protein kinase C activity 1.947E-04 6.049E-03 PKN1, PRKD2, PRKD3
BP GO:0022610; biological adhesion GO:0033628; regulation of cell adhesion mediated by integrin 1.973E-04 6.111E-03 CYP1B1, LYN, PTK2, RET
BP GO:0009987; cellular process GO:1903201; regulation of oxidative stress-induced cell death 2.008E-04 6.201E-03 AKT1, HIF1A, MET, MMP3, TP53
CC GO:0043226; organelle GO:0016604; nuclear body 2.143E-04 6.563E-03 ABL1, BLM, CDK2, CHEK2, HIF1A, LIMK1, LMNA, MAPK14, MAPT, MKNK2, NEK6, RORC, SMN1, SMN2, TP53
BP GO:0032502; developmental process GO:0031100; animal organ regeneration 2.276E-04 6.893E-03 AXL, CDK1, CSNK2A1, EGFR, FLT3
BP GO:0008152; metabolic process GO:0016311; dephosphorylation 2.311E-04 6.970E-03 ACP1, ALPI, CA3, CAMK2G, LCK, POLB, PTPN1, PTPN2, PTPRF
BP GO:0065007; biological regulation GO:1904355; positive regulation of telomere capping 2.352E-04 7.075E-03 AURKB, MAPK1, NEK2
BP Unclassified; GO:0051279; regulation of release of sequestered calcium ion into cytosol 2.420E-04 7.218E-03 ABL1, CACNA1C, CAMK2D, LYN, NPSR1
BP GO:0009987; cellular process GO:1901216; positive regulation of neuron death 2.420E-04 7.218E-03 ABL1, ATM, GSK3B, MAPT, TP53
BP GO:0009987; cellular process GO:0046427; positive regulation of JAK-STAT cascade 2.420E-04 7.218E-03 AKR1B1, CYP1B1, ERBB4, FLT3, LYN
BP GO:0023052; signaling GO:0050806; positive regulation of synaptic transmission 2.527E-04 7.508E-03 ADORA1, CA2, CA7, DRD4, EGFR, MAPK1
BP GO:0051179; localization GO:0046326; positive regulation of glucose import 2.620E-04 7.740E-03 AKT1, MAPK14, NR1H4, PIK3R1
BP GO:0009987; cellular process GO:1902905; positive regulation of supramolecular fiber organization 2.707E-04 7.966E-03 ABL1, ALOX15, HCK, LIMK1, MAPT, MET, NOX4
BP GO:0032502; developmental process GO:0045597; positive regulation of cell differentiation 2.749E-04 8.056E-03 ABL1, AKT1, AXL, CA2, CAMK2B, CCR2, CSNK1D, HIF1A, KDR, LIMK1, LYN, MAPK14, MAPK9, MAPT, NFKB1, RET, THPO
BP GO:0008152; metabolic process GO:0050999; regulation of nitric-oxide synthase activity 2.865E-04 8.308E-03 AKT1, EGFR, GLA, HIF1A
BP GO:0032501; multicellular organismal process GO:0097746; regulation of blood vessel diameter 2.885E-04 8.331E-03 ADORA1, ADRB1, AKT1, EGFR, HMGCR, KCNA5
BP GO:0009987; cellular process GO:2001235; positive regulation of apoptotic signaling pathway 3.005E-04 8.634E-03 GSK3B, LCK, MAPK9, MMP9, PTPN2, RET, TP53
BP GO:0065007; biological regulation GO:0032431; activation of phospholipase A2 activity 3.100E-04 8.812E-03 EGFR, PLA2G1B
BP GO:0009987; cellular process GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway 3.100E-04 8.812E-03 PTPN1, PTPN2
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 3.100E-04 8.812E-03 CYP1A1, CYP1A2
BP GO:0009987; cellular process GO:0090199; regulation of release of cytochrome c from mitochondria 3.127E-04 8.867E-03 AKT1, LMNA, MMP9, TP53
BP GO:0009987; cellular process GO:0090342; regulation of cell aging 3.406E-04 9.509E-03 ABL1, LMNA, NEK6, NUAK1
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 2.588E-21 1.311E-18 CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP GO:0008152; metabolic process GO:0018105; peptidyl-serine phosphorylation 1.971E-20 8.761E-18 AKT1, ATM, AURKB, CAMK2B, CAMK2D, CAMK2G, CDK1, CDK2, CHEK2, CSNK1D, GSK3B, HIPK4, MAPK1, MAPK14, MAPK9, MKNK2, NEK6, PHKG2, PKN1, PRKD2, SRC
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 5.473E-16 1.295E-13 ABL1, BLK, EGFR, ERBB4, FRK, HCK, IGF1R, KDR, LCK, LYN, PTK2, SRC
BP GO:0051179; localization GO:0015701; bicarbonate transport 1.217E-14 2.409E-12 CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP Unclassified; GO:0032844; regulation of homeostatic process 6.164E-14 1.104E-11 ABL1, ADORA1, ATM, AURKB, CA2, CA7, CACNA1C, CAMK2D, EGFR, HIF1A, HMGCR, KDR, LCK, LYN, MAP4K4, MAPK1, MAPK14, NEK2, NPSR1, NR1H4, PIM3, PLA2G1B, SRC, TRPA1
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 6.253E-14 1.107E-11 CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP GO:0008152; metabolic process GO:0018107; peptidyl-threonine phosphorylation 3.760E-13 6.020E-11 AKT1, CAMK2B, CAMK2D, CAMK2G, CDK1, CHEK2, CSNK2A1, GSK3B, MAPK1, PHKG2, PKN1, PRKD2
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa04012 ErbB signaling pathway_Homo sapiens_hsa04012 3.780E-17 3.798E-15 CAMK2B; GSK3B; CAMK2D; SRC; PIK3R1; EGFR; PTK2; MAPK10; MAPK9; ERBB4; ERBB2; ABL1; AKT1; MAPK1; CAMK2G
hsa05205 Proteoglycans in cancer_Homo sapiens_hsa05205 2.645E-16 1.772E-14 CAMK2B; CAMK2D; SRC; MMP2; PIK3R1; MAPK14; HIF1A; MMP9; PTK2; EGFR; IGF1R; ERBB4; ERBB2; KDR; AKT1; MAPK1; TP53; MET; CAMK2G
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 1.583E-20 3.181E-18 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 5.592E-15 2.810E-13 CAMK2B; GSK3B; CAMK2D; PIK3R1; IRAK4; MAPK14; NFKB1; MAPK10; MAPK9; IRAK1; ABL1; AKT1; MAPK1; TP53; CAMK2G
hsa05200 Pathways in cancer_Homo sapiens_hsa05200 5.768E-13 2.319E-11 RET; GSK3B; FLT3; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; EGFR; NFKB1; PTK2; IGF1R; MAPK10; MAPK9; CDK2; ERBB2; ABL1; AKT1; MAPK1; MET; TP53
hsa04912 GnRH signaling pathway_Homo sapiens_hsa04912 1.689E-12 5.657E-11 MAPK10; CAMK2B; MAPK9; CAMK2D; SRC; MMP2; MAPK1; CACNA1D; CACNA1C; MAPK14; CAMK2G; EGFR
hsa04510 Focal adhesion_Homo sapiens_hsa04510 1.244E-11 3.126E-10 GSK3B; SRC; FLT4; PIK3R1; PTK2; EGFR; MYLK; IGF1R; MAPK10; MAPK9; ERBB2; KDR; AKT1; MAPK1; MET
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 7.622E-12 2.189E-10 CAMK2B; CAMK2D; MKNK2; ERBB2; AKT1; MAPK1; PIK3R1; HIF1A; CAMK2G; EGFR; NFKB1; IGF1R
hsa04750 Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 8.859E-11 1.619E-09 MAPK10; CYP2J2; CAMK2B; MAPK9; CAMK2D; TRPA1; SRC; ALOX12; PIK3R1; MAPK14; CAMK2G
hsa05230 Central carbon metabolism in cancer_Homo sapiens_hsa05230 3.604E-11 7.244E-10 RET; FLT3; ERBB2; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A; EGFR
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 1.279E-10 1.836E-09 CAMK2B; CAMK2D; ADRB1; CACNA1D; PIK3R1; CACNA1C; NFKB1; TSHR; MAPK10; MAPK9; ADORA1; AKT1; MAPK1; CAMK2G
hsa04728 Dopaminergic synapse_Homo sapiens_hsa04728 1.117E-10 1.728E-09 MAPK10; CAMK2B; GSK3B; MAPK9; CAMK2D; MAOA; AKT1; CACNA1D; CACNA1C; MAPK14; CAMK2G; DRD4
hsa04520 Adherens junction_Homo sapiens_hsa04520 1.002E-10 1.678E-09 PTPN1; CSNK2A1; SRC; ERBB2; MAPK1; ACP1; MET; PTPRF; EGFR; IGF1R
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 3.819E-10 4.797E-09 CYP2J2; CYP2C9; CYP2C8; MAOA; ALOX5; ALOX15; MAPK1; CACNA1D; ALOX12; CACNA1C; CYP2C19
hsa05215 Prostate cancer_Homo sapiens_hsa05215 6.486E-10 7.669E-09 GSK3B; CDK2; ERBB2; AKT1; MAPK1; PIK3R1; TP53; EGFR; NFKB1; IGF1R
hsa05214 Glioma_Homo sapiens_hsa05214 7.138E-10 7.970E-09 CAMK2B; CAMK2D; AKT1; MAPK1; PIK3R1; TP53; CAMK2G; EGFR; IGF1R
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 1.786E-11 3.989E-10 CYP2J2; CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa05169 Epstein-Barr virus infection_Homo sapiens_hsa05169 1.803E-09 1.594E-08 LYN; GSK3B; CSNK2A1; PIK3R1; MAPK14; NFKB1; MAPK10; MAPK9; IRAK1; CDK2; CDK1; AKT1; TP53
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 8.054E-10 8.257E-09 MAPK10; MAPK9; ABCC1; ADORA3; ADORA1; AKT1; MAPK1; PIK3R1; MAPK14; TP53; NFKB1
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 8.216E-10 8.257E-09 MAPK10; MAPK9; ERBB2; AKT1; MAPK1; PIK3R1; TP53; EGFR; NFKB1
hsa05219 Bladder cancer_Homo sapiens_hsa05219 3.705E-10 4.797E-09 DAPK1; SRC; MMP2; ERBB2; MAPK1; MMP9; TP53; EGFR
hsa05120 Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 1.081E-09 1.035E-08 LYN; MAPK10; MAPK9; CXCR1; SRC; MAPK14; MET; EGFR; NFKB1
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 1.823E-09 1.594E-08 MAPK10; GSK3B; MAPK9; SRC; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 7.407E-09 5.134E-08 PLA2G1B; FLT4; PIK3R1; EGFR; NFKB1; IGF1R; MAPK10; MAPK9; KDR; ABL1; AKT1; MAPK1; MET
hsa05161 Hepatitis B_Homo sapiens_hsa05161 6.506E-09 4.829E-08 MAPK10; MAPK9; SRC; CDK2; AKT1; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1
hsa05152 Tuberculosis_Homo sapiens_hsa05152 4.617E-09 3.569E-08 MAPK10; CAMK2B; MAPK9; CAMK2D; IRAK1; SRC; AKT1; MAPK1; IRAK4; MAPK14; CAMK2G; NFKB1
hsa04910 Insulin signaling pathway_Homo sapiens_hsa04910 3.873E-09 3.114E-08 MAPK10; PTPN1; GSK3B; MAPK9; MKNK2; PHKG2; AKT1; MAPK1; PIK3R1; PYGL; PTPRF
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 1.047E-08 7.014E-08 MAPK10; MAPK9; IRAK1; ALOX5; AKT1; MAPK1; PIK3R1; IRAK4; MAPK14; NFKB1
hsa04010 MAPK signaling pathway_Homo sapiens_hsa04010 2.959E-08 1.802E-07 CACNA1D; CACNA1C; MAPK14; EGFR; NFKB1; MAPK10; MAPK9; MKNK2; AKT1; MAPK1; MAPT; TP53; MAP4K4
hsa04015 Rap1 signaling pathway_Homo sapiens_hsa04015 3.103E-08 1.835E-07 PRKD3; SRC; FLT4; KDR; AKT1; MAPK1; PRKD2; PIK3R1; MAPK14; MET; EGFR; IGF1R
hsa04913 Ovarian steroidogenesis_Homo sapiens_hsa04913 1.975E-09 1.654E-08 CYP2J2; HSD17B1; ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R
hsa04914 Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 2.891E-08 1.802E-07 MAPK10; MAPK9; CDK2; CDK1; AKT1; MAPK1; PIK3R1; MAPK14; IGF1R
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 3.770E-08 2.048E-07 MAPK10; MAPK9; MMP2; PIM1; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1
hsa04020 Calcium signaling pathway_Homo sapiens_hsa04020 5.730E-08 2.892E-07 CAMK2B; CAMK2D; ERBB4; ERBB2; PHKG2; CACNA1D; ADRB1; CACNA1C; CAMK2G; EGFR; MYLK
hsa05160 Hepatitis C_Homo sapiens_hsa05160 3.316E-08 1.852E-07 MAPK10; GSK3B; MAPK9; AKT1; MAPK1; PIK3R1; MAPK14; TP53; EGFR; NFKB1
hsa04068 FoxO signaling pathway_Homo sapiens_hsa04068 3.316E-08 1.852E-07 MAPK10; MAPK9; CDK2; AKT1; MAPK1; ATM; PIK3R1; MAPK14; EGFR; IGF1R
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 5.755E-08 2.892E-07 MAPK10; MAPK9; IRAK1; AKT1; MAPK1; PIK3R1; IRAK4; MAPK14; NFKB1
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 4.872E-08 2.577E-07 MAPK10; MAPK9; IRAK1; AKT1; MAPK1; PIK3R1; IRAK4; MAPK14; NFKB1
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 1.159E-08 7.514E-08 CYP2J2; CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 8.463E-08 3.840E-07 LYN; GSK3B; HCK; CXCR1; SRC; AKT1; MAPK1; PIK3R1; NFKB1; PTK2; CCR2
hsa04725 Cholinergic synapse_Homo sapiens_hsa04725 8.598E-08 3.840E-07 CAMK2B; ACHE; CAMK2D; AKT1; MAPK1; CACNA1D; PIK3R1; CACNA1C; CAMK2G
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 1.264E-07 5.184E-07 GSK3B; FLT4; PIK3R1; PTK2; EGFR; NFKB1; IGF1R; CDK2; KDR; AKT1; MAPK1; PKN1; TP53; MET
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 6.727E-09 4.829E-08 HSD11B1; HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 7.948E-08 3.715E-07 MAPK10; MAPK9; MMP3; AKT1; MAPK1; PIK3R1; MAPK14; MMP9; NFKB1
hsa04931 Insulin resistance_Homo sapiens_hsa04931 7.341E-08 3.513E-07 MAPK10; PTPN1; GSK3B; MAPK9; AKT1; PIK3R1; PYGL; NFKB1; PTPRF
hsa04261 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 9.157E-08 4.001E-07 CAMK2B; CAMK2D; AKT1; MAPK1; CACNA1D; ADRB1; PIK3R1; CACNA1C; MAPK14; CAMK2G
hsa04921 Oxytocin signaling pathway_Homo sapiens_hsa04921 1.693E-07 6.807E-07 CAMK2B; CAMK2D; SRC; MAPK1; CACNA1D; PIK3R1; CACNA1C; CAMK2G; EGFR; MYLK
hsa04210 Apoptosis_Homo sapiens_hsa04210 6.279E-07 2.214E-06 MAPK10; MAPK9; LMNA; AKT1; MAPK1; ATM; PIK3R1; TP53; NFKB1
hsa05162 Measles_Homo sapiens_hsa05162 4.914E-07 1.796E-06 GSK3B; IRAK1; CSNK2A1; CDK2; AKT1; PIK3R1; IRAK4; TP53; NFKB1
hsa05202 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 5.675E-07 2.037E-06 FLT3; MMP3; ATM; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 1.237E-06 4.010E-06 ABCC1; ERBB2; PIM1; ABL1; CYP1B1; MAPK1; ATM; TP53; MMP9; MET; EGFR; NFKB1
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 1.086E-07 4.646E-07 HSD11B1; CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19
hsa05213 Endometrial cancer_Homo sapiens_hsa05213 7.285E-08 3.513E-07 GSK3B; ERBB2; AKT1; MAPK1; PIK3R1; TP53; EGFR
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 6.899E-07 2.350E-06 GSK3B; MAPK9; LCK; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 5.076E-06 1.457E-05 CYP2J2; PLA2G1B; MAOA; GAA; ALOX15; AKR1B1; ALOX12; HMGCR; PYGL; CYP2C19; CYP3A4; CYP19A1; HSD17B10; HSD11B1; CYP2C9; CYP2C8; AKR1B10; HSD17B1; ALOX5; HSD17B2; CYP1A2; CYP1A1; ALPI; XDH
hsa04022 cGMP-PKG signaling pathway_Homo sapiens_hsa04022 2.734E-06 8.454E-06 ADORA3; ADORA1; AKT1; MAPK1; CACNA1D; ADRB1; PIK3R1; CACNA1C; MYLK
hsa05164 Influenza A_Homo sapiens_hsa05164 4.014E-06 1.201E-05 MAPK10; GSK3B; MAPK9; AKT1; MAPK1; PIK3R1; IRAK4; MAPK14; NFKB1
hsa04114 Oocyte meiosis_Homo sapiens_hsa04114 2.468E-06 7.750E-06 CAMK2B; CAMK2D; SLK; CDK2; CDK1; MAPK1; CAMK2G; IGF1R
hsa04664 Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 4.809E-07 1.790E-06 LYN; MAPK10; MAPK9; AKT1; MAPK1; PIK3R1; MAPK14
hsa05223 Non-small cell lung cancer_Homo sapiens_hsa05223 1.234E-07 5.166E-07 ALK; ERBB2; AKT1; MAPK1; PIK3R1; TP53; EGFR
hsa04370 VEGF signaling pathway_Homo sapiens_hsa04370 2.254E-07 8.884E-07 SRC; KDR; AKT1; MAPK1; PIK3R1; MAPK14; PTK2
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 4.185E-06 1.219E-05 MAPK10; MAPK9; LCK; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1
hsa04310 Wnt signaling pathway_Homo sapiens_hsa04310 7.190E-06 1.953E-05 MAPK10; CAMK2B; GSK3B; MAPK9; CAMK2D; CSNK2A1; TP53; CAMK2G
hsa05218 Melanoma_Homo sapiens_hsa05218 6.483E-07 2.247E-06 AKT1; MAPK1; PIK3R1; TP53; MET; EGFR; IGF1R
hsa05210 Colorectal cancer_Homo sapiens_hsa05210 2.526E-07 9.765E-07 MAPK10; GSK3B; MAPK9; AKT1; MAPK1; PIK3R1; TP53
hsa04925 Aldosterone synthesis and secretion_Homo sapiens_hsa04925 1.599E-06 5.103E-06 CAMK2B; CAMK2D; PRKD3; PRKD2; CACNA1D; CACNA1C; CAMK2G
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 1.441E-05 3.621E-05 LYN; POLB; SRC; CDK2; CDK1; MAPK1; PIK3R1; TP53; NFKB1
hsa04915 Estrogen signaling pathway_Homo sapiens_hsa04915 6.167E-06 1.746E-05 SRC; MMP2; AKT1; MAPK1; PIK3R1; MMP9; EGFR
hsa04922 Glucagon signaling pathway_Homo sapiens_hsa04922 7.043E-06 1.939E-05 CAMK2B; CAMK2D; PHKG2; AKT1; SIK2; PYGL; CAMK2G
hsa05231 Choline metabolism in cancer_Homo sapiens_hsa05231 7.043E-06 1.939E-05 MAPK10; MAPK9; AKT1; MAPK1; PIK3R1; HIF1A; EGFR
hsa04064 NF-kappa B signaling pathway_Homo sapiens_hsa04064 4.064E-06 1.201E-05 LYN; IRAK1; CSNK2A1; LCK; ATM; IRAK4; NFKB1
hsa05131 Shigellosis_Homo sapiens_hsa05131 3.514E-07 1.333E-06 MAPK10; MAPK9; SRC; ABL1; MAPK1; MAPK14; NFKB1
hsa05133 Pertussis_Homo sapiens_hsa05133 9.453E-07 3.167E-06 MAPK10; MAPK9; IRAK1; MAPK1; IRAK4; MAPK14; NFKB1
hsa04611 Platelet activation_Homo sapiens_hsa04611 2.428E-05 5.952E-05 LYN; SRC; AKT1; MAPK1; PIK3R1; MAPK14; MYLK
hsa04919 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 1.956E-05 4.854E-05 GSK3B; SRC; AKT1; MAPK1; PIK3R1; TP53; HIF1A
hsa04144 Endocytosis_Homo sapiens_hsa04144 8.932E-05 1.890E-04 RET; CXCR1; ERBB4; SRC; KDR; ADRB1; MET; EGFR; IGF1R
hsa05166 HTLV-I infection_Homo sapiens_hsa05166 8.672E-05 1.854E-04 POLB; GSK3B; LCK; CHEK2; AKT1; ATM; PIK3R1; TP53; NFKB1
hsa04110 Cell cycle_Homo sapiens_hsa04110 2.697E-05 6.532E-05 GSK3B; CHEK2; CDK2; ABL1; CDK1; ATM; TP53
hsa04360 Axon guidance_Homo sapiens_hsa04360 3.146E-05 7.354E-05 GSK3B; LIMK1; ABL1; MAPK1; MET; PTK2; EPHB4
hsa04060 Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 5.664E-04 1.035E-03 CXCR1; THPO; FLT3; FLT4; KDR; MET; EGFR; CCR2
hsa05168 Herpes simplex infection_Homo sapiens_hsa05168 3.302E-04 6.261E-04 MAPK10; MAPK9; CSNK2A1; CDK2; CDK1; TP53; NFKB1
hsa04810 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 7.864E-04 1.399E-03 SRC; LIMK1; MAPK1; PIK3R1; PTK2; EGFR; MYLK
hsa04666 Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 4.886E-05 1.092E-04 LYN; HCK; LIMK1; AKT1; MAPK1; PIK3R1
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 1.834E-04 3.544E-04 BACE1; GSK3B; MAPK1; CACNA1D; CACNA1C; MAPT; HSD17B10
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 1.224E-05 3.113E-05 LYN; GSK3B; AKT1; MAPK1; PIK3R1; NFKB1
hsa04550 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 4.958E-04 9.228E-04 GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; IGF1R
hsa04932 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 6.855E-04 1.241E-03 MAPK10; GSK3B; MAPK9; AKT1; PIK3R1; NFKB1
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 1.224E-05 3.113E-05 ABL1; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa04723 Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 7.760E-05 1.677E-04 MAPK10; MAPK9; MAPK1; CACNA1D; CACNA1C; MAPK14
hsa04630 Jak-STAT signaling pathway_Homo sapiens_hsa04630 8.685E-04 1.518E-03 THPO; PIM1; AKT1; STAT6; PIK3R1; PTPN2
hsa04072 Phospholipase D signaling pathway_Homo sapiens_hsa04072 3.459E-03 5.652E-03 CXCR1; AKT1; MAPK1; PIK3R1; EGFR
hsa04152 AMPK signaling pathway_Homo sapiens_hsa04152 1.130E-02 1.734E-02 AKT1; PIK3R1; HMGCR; IGF1R
hsa05146 Amoebiasis_Homo sapiens_hsa05146 3.319E-02 4.765E-02 PIK3R1; NFKB1; PTK2
hsa04713 Circadian entrainment_Homo sapiens_hsa04713 5.507E-05 1.203E-04 CAMK2B; CAMK2D; MAPK1; CACNA1D; CACNA1C; CAMK2G
hsa05222 Small cell lung cancer_Homo sapiens_hsa05222 3.137E-05 7.354E-05 CDK2; AKT1; PIK3R1; TP53; NFKB1; PTK2
hsa04540 Gap junction_Homo sapiens_hsa04540 3.574E-05 8.258E-05 SRC; CDK1; MAPK1; ADRB1; CSNK1D; EGFR
hsa05132 Salmonella infection_Homo sapiens_hsa05132 3.137E-05 7.354E-05 MAPK10; MAPK9; MAPK1; PKN1; MAPK14; NFKB1
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 2.859E-06 8.706E-06 FLT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1
hsa04670 Leukocyte transendothelial migration_Homo sapiens_hsa04670 1.453E-03 2.470E-03 MMP2; PIK3R1; MAPK14; MMP9; PTK2
hsa04727 GABAergic synapse_Homo sapiens_hsa04727 2.392E-02 3.509E-02 SRC; CACNA1D; CACNA1C
hsa05031 Amphetamine addiction_Homo sapiens_hsa05031 7.424E-06 1.990E-05 CAMK2B; CAMK2D; MAOA; CACNA1D; CACNA1C; CAMK2G
hsa04916 Melanogenesis_Homo sapiens_hsa04916 6.913E-04 1.241E-03 CAMK2B; GSK3B; CAMK2D; MAPK1; CAMK2G
hsa04270 Vascular smooth muscle contraction_Homo sapiens_hsa04270 1.566E-03 2.601E-03 PLA2G1B; MAPK1; CACNA1D; CACNA1C; MYLK
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 1.224E-05 3.113E-05 HSD11B1; CYP2C9; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa04211 Longevity regulating pathway - mammal_Homo sapiens_hsa04211 5.212E-04 9.610E-04 AKT1; PIK3R1; TP53; NFKB1; IGF1R
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 8.816E-06 2.332E-05 CYP2C9; CYP2C8; MAOA; CYP1A2; CYP3A4; CYP2C19
hsa05410 Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 2.053E-02 3.057E-02 LMNA; CACNA1D; CACNA1C
hsa05414 Dilated cardiomyopathy_Homo sapiens_hsa05414 3.691E-03 5.982E-03 LMNA; ADRB1; CACNA1D; CACNA1C
hsa04911 Insulin secretion_Homo sapiens_hsa04911 3.275E-04 6.261E-04 CAMK2B; CAMK2D; CACNA1D; CACNA1C; CAMK2G
hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 1.516E-02 2.302E-02 LMNA; CACNA1D; CACNA1C
hsa05100 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 2.197E-03 3.620E-03 SRC; PIK3R1; MET; PTK2
hsa05140 Leishmaniasis_Homo sapiens_hsa05140 1.604E-04 3.191E-04 IRAK1; MAPK1; IRAK4; MAPK14; NFKB1
hsa04930 Type II diabetes mellitus_Homo sapiens_hsa04930 1.018E-06 3.354E-06 MAPK10; MAPK9; MAPK1; CACNA1D; PIK3R1; CACNA1C
hsa04971 Gastric acid secretion_Homo sapiens_hsa04971 1.710E-04 3.370E-04 CAMK2B; CAMK2D; CA2; CAMK2G; MYLK
hsa04213 Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 1.025E-02 1.609E-02 AKT1; PIK3R1; IGF1R
hsa05321 Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 1.069E-02 1.665E-02 RORC; STAT6; NFKB1
hsa04730 Long-term depression_Homo sapiens_hsa04730 8.588E-03 1.359E-02 LYN; MAPK1; IGF1R
hsa04976 Bile secretion_Homo sapiens_hsa04976 1.406E-04 2.825E-04 CA2; NR1H4; HMGCR; CYP3A4; ABCG2
hsa05211 Renal cell carcinoma_Homo sapiens_hsa05211 9.922E-05 2.035E-04 AKT1; MAPK1; PIK3R1; MET; HIF1A
hsa04920 Adipocytokine signaling pathway_Homo sapiens_hsa04920 1.475E-03 2.470E-03 MAPK10; MAPK9; AKT1; NFKB1
hsa04720 Long-term potentiation_Homo sapiens_hsa04720 9.922E-05 2.035E-04 CAMK2B; CAMK2D; MAPK1; CACNA1C; CAMK2G
hsa04115 p53 signaling pathway_Homo sapiens_hsa04115 1.227E-04 2.491E-04 CHEK2; CDK2; CDK1; ATM; TP53
hsa04923 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 4.485E-05 1.025E-04 ADORA1; AKT1; ADRB1; PIK3R1; TSHR
hsa04622 RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 1.475E-03 2.470E-03 MAPK10; MAPK9; MAPK14; NFKB1
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 9.222E-05 1.931E-04 CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP3A4
hsa00561 Glycerolipid metabolism_Homo sapiens_hsa00561 8.200E-03 1.308E-02 AKR1B10; AKR1B1; GLA
hsa04924 Renin secretion_Homo sapiens_hsa04924 1.055E-03 1.829E-03 ADORA1; ADRB1; CACNA1D; CACNA1C
hsa04150 mTOR signaling pathway_Homo sapiens_hsa04150 8.277E-04 1.459E-03 AKT1; MAPK1; PIK3R1; HIF1A
hsa04621 NOD-like receptor signaling pathway_Homo sapiens_hsa04621 4.889E-05 1.092E-04 MAPK10; MAPK9; MAPK1; MAPK14; NFKB1
hsa04960 Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 3.045E-02 4.403E-02 MAPK1; PIK3R1
hsa04973 Carbohydrate digestion and absorption_Homo sapiens_hsa04973 3.842E-03 6.179E-03 AKT1; CACNA1D; PIK3R1
hsa00040 Pentose and glucuronate interconversions_Homo sapiens_hsa00040 2.624E-02 3.822E-02 AKR1B10; AKR1B1
hsa04320 Dorso-ventral axis formation_Homo sapiens_hsa04320 1.523E-02 2.302E-02 MAPK1; EGFR
hsa00051 Fructose and mannose metabolism_Homo sapiens_hsa00051 2.104E-02 3.109E-02 AKR1B10; AKR1B1
hsa04710 Circadian rhythm_Homo sapiens_hsa04710 1.862E-02 2.793E-02 RORC; CSNK1D
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 1.728E-04 3.373E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa05216 Thyroid cancer_Homo sapiens_hsa05216 1.074E-03 1.844E-03 RET; MAPK1; TP53
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 5.472E-05 1.203E-04 AKR1B10; GAA; AKR1B1; GLA
hsa04964 Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 1.118E-02 1.728E-02 CA2; CA4
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 4.798E-04 9.014E-04 CYP1A2; XDH
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 ACHE; CA1
A00-B99: Certain infectious and parasitic diseases Infections disease A00-B99 MPO
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 MAOA
C00-D49: Neoplasms Advanced breast cancer C50 CYP19A1; SRC
I00-I99: Diseases of the circulatory system Acute supraventricular tachycardia I47.1 ADRB1
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH
G00-G99: Diseases of the nervous system G00-G99 Central nervous system disease G00-G99 MAPT
G00-G99: Diseases of the nervous system G00-G99 Central and peripheral nervous diseases G96.9 ADRB1
P00-P96: Certain conditions originating in the perinatal period Central nervous system injury P11.9 MAPK10
I00-I99: Diseases of the circulatory system Cerebrovascular ischaemia I61-I63 HMGCR; ADORA3; EGFR
G00-G99: Diseases of the nervous system G00-G99 Multiple scierosis G35 MPO; ADORA1; CCR2; CCR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 MAOA; CAMK2B; ACHE; CAMK2D; CAMK2G; CYP3A4
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 KDR
NA: NA Cardiogenic shock NA ADRB1
E00-E89: Endocrine, nutritional and metabolic diseases Fabry's disease E75.2 GLA
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR; KDR
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR
C00-D49: Neoplasms Advanced cancers C00-C96 EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 MAPT; ACHE; ADORA1
C00-D49: Neoplasms CLL NA FLT3
I00-I99: Diseases of the circulatory system Circulatory disorders I00-I99 ADRB1
C00-D49: Neoplasms Clear cell renal cell carcinoma C64 CA9
J00-J99: Diseases of the respiratory system Allergic rhinitis J00, J30, J31.0, T78.4 PLA2G1B
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53
C00-D49: Neoplasms Breast cancer C50 CYP19A1; FLT3; FLT3; CA9; IGF1R; CDK1; EGFR; EGFR; EGFR; ERBB2; ERBB2; ERBB2; KDR; KDR; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 MAOA
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Chronic pain R52.1-R52.2, G89 ERBB2
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 MPO; ALOX5; MAPK14; CCR2
C00-D49: Neoplasms Chronic myelogenous leukaemia C92.1 ABL1; ABL1; SRC
C00-D49: Neoplasms Chronic lymphocytic leukaemia C91 LYN; EGFR
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 MAPT; ACHE; RET
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R
I00-I99: Diseases of the circulatory system Acute and chronic heart failure I50 ADORA1
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 MMP2
I00-I99: Diseases of the circulatory system Acute coronary syndrome I74 MAPK14
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; FLT4; ADORA3; KDR
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 PLA2G1B; ALOX5; ADORA1; ADRB1
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 MAOA; MAPT; ACHE; ACHE; ACHE; GSK3B; CCR2
C00-D49: Neoplasms AML NA FLT3; KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue Bone disease M00-M99 LYN
C00-D49: Neoplasms Brain cancer C71, D33 SRC; EGFR; EGFR
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9
I00-I99: Diseases of the circulatory system Heart arrhythmia I47-I49 CACNA1C; ADRB1
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 MPO; PLA2G1B; ALOX5; MMP13; IRAK4; MAPK14; CCR2
NA: NA Angina NA ADRB1; ADRB1
C00-D49: Neoplasms Biliary cancer C22, C24 KDR
C00-D49: Neoplasms Bladder cancer C67 CYP19A1; EGFR; ERBB2
C00-D49: Neoplasms Thyroid cancer C73 TSHR; RET; KDR
C00-D49: Neoplasms Thymoma C37, D15.0 CDK2
I00-I99: Diseases of the circulatory system Thrombosis I80-I82 HMGCR; ALOX5
J00-J99: Diseases of the respiratory system Throat irritation J39.2 TRPA1
NA: NA Acute respiratory distress syndrome NA MAPK14
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR
I00-I99: Diseases of the circulatory system Angina pectoris I20 CACNA1C; ADRB1; ADRB1; ADRB1; KCNA5
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A
I00-I99: Diseases of the circulatory system Cardiac arrhythmias I47-I49 ADORA1; ADORA1; ADRB1
I00-I99: Diseases of the circulatory system Cardiac disease I00-I99 ADORA1
I00-I99: Diseases of the circulatory system Cardiac failure I50 CACNA1C
NA: NA Cardiovascular disease NA HMGCR
C00-D49: Neoplasms HER2-positive urogenital cancer NA ERBB2
C00-D49: Neoplasms Cancer C00-C96 MET; CSNK2A1; AKT1; FLT3; FLT3; CA9; ABL1; MMP2; ACHE; SRC; IGF1R; PTK2; ERBB4; CDK2; FLT4; EPHB4; GSK3B; ADORA3; HIF1A; MAPK9; CDK1; MAPK1; MAPK14; MMP9; NFKB1; EGFR; ERBB2; ERBB2; PIM1; TP53; RET; CA1; KDR; CHEK2
C00-D49: Neoplasms Multiple myeloma C90 HMGCR; SRC; IGF1R
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes Vulnerary S00-T98 EGFR
NA: NA Edema NA CA2
C00-D49: Neoplasms Ovarian cancer C56 MMP2; EGFR; EGFR; KDR; KDR; KDR; KDR
C00-D49: Neoplasms Metastatic cancer NA CCR2
C00-D49: Neoplasms Metastasis C00-C97 AXL
C00-D49: Neoplasms Metastatic breast cancer C50 KDR
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic disorders E70-E89 HSD11B1; GPBAR1
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic syndrome x E88.81 HSD11B1
C00-D49: Neoplasms Mesothelioma C45 PTK2
C00-D49: Neoplasms Pancreatic cancer C25 AKT1; FLT3; MMP2; EGFR; KDR
NA: NA Rheumatold arthritis NA MAPK14
J00-J99: Diseases of the respiratory system Rhinitis J00, J30, J31.0 ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 AKR1B1; PLA2G1B; ALOX5; MMP3; CAMK2B; CAMK2D; CAMK2G; MAPK14; CCR2; CCR2
H00-H59: Diseases of the eye and adnexa Retinal venous occlusion H34.8 ERBB2
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 MAOA
I00-I99: Diseases of the circulatory system Ventricular fibrillation I49.01 ADRB1
NA: NA Ventricular premature beats NA ADRB1
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
NA: NA Dyslipidemia NA HMGCR
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 MYLK; CA2; CA1
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 EGFR; KDR
G00-G99: Diseases of the nervous system G00-G99 Migraine G43 ADRB1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Schizophrenia F20 DRD4
A00-B99: Certain infectious and parasitic diseases Sepsis A40, A41 ADORA1; ADRB1
S00-T88: Injury, poisoning and certain other consequences of external causes Vascular restinosis following vascular graft surgery T82.858A FLT4
I00-I99: Diseases of the circulatory system Orthostatic hypotension I95.1 ADORA1
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 ALOX5; MMP13; MMP3; MMP2
A00-B99: Certain infectious and parasitic diseases Malaria B54 ADORA3
I00-I99: Diseases of the circulatory system Maintenance of normal sinus rhythm I46-I49 ADRB1
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R
K00-K95: Diseases of the digestive system Ulcerative colitis K51 MMP9
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 PLA2G1B; ABCC1; ALOX5; MAPK14; CCR2
I00-I99: Diseases of the circulatory system Arteriosclerosis I70 HMGCR; PLA2G1B; CCR2
I00-I99: Diseases of the circulatory system Arrhythmia I47-I49 KCNA5
C00-D49: Neoplasms Melanoma C43 EGFR; KDR; KDR
C00-D49: Neoplasms Malignant tumor C00-C75, C7A, C7B EGFR
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Fatigue R53 ADORA1
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR
G00-G99: Diseases of the nervous system G00-G99 Spinal muscular atrophy G00-G99 SMN1;SMN2
C00-D49: Neoplasms Solid tumours C00-D48 MET; AKT1; FLT3; CA9; ABL1; MMP2; SRC; IGF1R; PTK2; ERBB4; AURKB; CDK2; FLT4; HIF1A; MAPK1; MMP9; EGFR; ERBB2; TP53; RET; KDR; KDR; KDR; CHEK2
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 HSD11B1; PTPN1; PTPN1; NFKB1; GPBAR1
A00-B99: Certain infectious and parasitic diseases Septic shock A41.9 ADRB1
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET
I00-I99: Diseases of the circulatory system Heart failure I50 ADORA1; XDH; ADRB1; ADRB1
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53
C00-D49: Neoplasms Head and neck squamous cell carcinoma C44 EGFR
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1; EGFR; EGFR; EGFR; TP53; KDR; KDR
C00-D49: Neoplasms Late-stage non-small cell lung cancer C33-C34 EPHB4
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
C00-D49: Neoplasms Leukemia C90-C95 AKT1; FLT3; ABL1
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A PTK2; TP53
E00-E89: Endocrine, nutritional and metabolic diseases Lipid metabolism disorder E75-E78 HSD11B1
C00-D49: Neoplasms Liver cancer C22 IGF1R; KDR
C00-D49: Neoplasms Lung cancer C33-C34 ABL1; MMP2; FLT4; EGFR
C00-D49: Neoplasms Locally advanced head and neck cancer C07-C14, C32, C33 EGFR
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
S00-T88: Injury, poisoning and certain other consequences of external causes Myocardial reperfusion injury T86.4 AKT1
S00-T88: Injury, poisoning and certain other consequences of external causes Nerve injury T14.4 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp L20-L30 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 ALOX5; FLT3; MAPK14; EGFR
L00-L99: Diseases of the skin and subcutaneous tissue Pruritus L29 PLA2G1B; ALOX5
C00-D49: Neoplasms Prostate cancer C61 FLT3; ABL1; FLT4; EGFR; ERBB2
N00-N99: Diseases of the genitourinary system Prostate disease N42.9 CYP19A1
L00-L99: Diseases of the skin and subcutaneous tissue Dermatitis L20-L30 ALOX5
I00-I99: Diseases of the circulatory system Atherosclerosis I70 HSD11B1; HMGCR; ALOX5; CCR2
J00-J99: Diseases of the respiratory system Asthma J45 PLA2G1B; ALOX5; ALOX5; ADORA1; ERBB2
A00-B99: Certain infectious and parasitic diseases HBV infection B16, B18.0, B18.1 HMGCR
C00-D49: Neoplasms Lymphoma C81-C86 AKT1; CA9; HIF1A; EGFR; ERBB2
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET
C00-D49: Neoplasms Myelodysplastic syndrome D46 KDR
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychotic disorders F20-F29 DRD4
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9
E00-E89: Endocrine, nutritional and metabolic diseases Autoimmune diabetes E08-E13 ADORA1; LCK
C00-D49: Neoplasms Glioblastoma NA FLT3
C00-D49: Neoplasms Glioblastoma multiforme C71 SRC; EGFR; EGFR; ERBB2
C00-D49: Neoplasms Glioma C71 ABL1; EGFR; EGFR; KDR
C00-D49: Neoplasms Gliosarcoma NA FLT3
NA: NA GIST NA FLT3
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1; ACHE; ADORA3; ADORA1; ADRB1; CA1; CA1
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1; ABCC1; ABCC1; XDH
J00-J99: Diseases of the respiratory system Influenza virus J11.1 HSD11B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CA2
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses L20-L30 PLA2G1B
C00-D49: Neoplasms Inflammatory breast cancer C50 EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 MAOA; MAOA
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 HSD11B1; PTPN1
C00-D49: Neoplasms Non-small-cell lung cancer NA EGFR
C00-D49: Neoplasms Non-hodgkin's lymphoma C85 ERBB2
E00-E89: Endocrine, nutritional and metabolic diseases Non-insulin dependent diabetes E11.9 HSD11B1
C00-D49: Neoplasms Refractory breast cancer C50 EGFR
K00-K95: Diseases of the digestive system Gastrointestinal disease K00-K93 EGFR
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 ERBB2; KDR
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH
C00-D49: Neoplasms Intestinal cancer NA ABL1
I00-I99: Diseases of the circulatory system Ischemic stroke I61-I63 MMP3
I00-I99: Diseases of the circulatory system Ischemia I99.8 SRC; ADORA3
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 MAOA; ADORA1; CCR2
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 NPSR1
NA: NA Neurogenic shock NA ADRB1
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 HMGCR; KDR
C00-D49: Neoplasms Renal cancer C64 CA9; KDR
C00-D49: Neoplasms Renal cell carcinoma NA MMP2; KDR; KDR
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53
N00-N99: Diseases of the genitourinary system Renal failure N17, N18, N19 ADORA1
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1
J00-J99: Diseases of the respiratory system Respiratory disease J00-J99 ALOX5
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR
A00-B99: Certain infectious and parasitic diseases Cryptosporidium infection A07.2 EGFR
I00-I99: Diseases of the circulatory system Coronary artery disease I20-I25 MAPK14; MAPK14; ADRB1
E00-E89: Endocrine, nutritional and metabolic diseases Hyperlipidaemia E78 HMGCR; ADORA1
NA: NA Hyperlipidemia NA HMGCR
I00-I99: Diseases of the circulatory system Hypertension I10-I16 ADORA1; ADRB1; ADRB1; ADRB1; ADRB1; ADRB1; ADRB1
E00-E89: Endocrine, nutritional and metabolic diseases Hypertriglyceridemia E78.1, E78.2, E78.3, I47-I49 ADORA1
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
NA: NA Inflammatory diseases NA MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 HSD11B1; HSD11B1; AKR1B1; PTPN1; GSK3B; ADORA1; ADRB1
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH
C00-D49: Neoplasms Myeloid leukemia C92 FLT3; ABL1
E00-E89: Endocrine, nutritional and metabolic diseases Pompe's disease E74.02 GAA
I00-I99: Diseases of the circulatory system Myocardial infarction I21, I22 HMGCR; MMP3
E00-E89: Endocrine, nutritional and metabolic diseases Hypercholesterolemia E78 HSD11B1; HMGCR
E00-E89: Endocrine, nutritional and metabolic diseases Atrial fibrillation E78, I48 ADORA1; ADORA1; KCNA5
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 HSD11B1; ADRB1; ADRB1; CA4; CA4
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 ACHE; ADRB1; ADRB1; CA4; CA2
C00-D49: Neoplasms Gastric cancer C16 EGFR; EGFR; ERBB2; KDR; KDR
NA: NA Metastatic hormone refractory prostate cancer NA LYN
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic nephropathy E11.21 CCR2
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
L00-L99: Diseases of the skin and subcutaneous tissue Diabetic foot ulcer L88-L89 EGFR
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 IGF1R
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 ADRB1; ADRB1; CA2
C00-D49: Neoplasms Hormonally-responsive breast cancer C50 CYP19A1
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3
E00-E89: Endocrine, nutritional and metabolic diseases Inflammation E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 ALOX5; ADORA3
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 MAPK14
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 MMP13; ACHE; IGF1R; CDK1; TRPA1; KCNA5
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE
NA: NA Colour dead tissues NA PTPN1
H00-H59: Diseases of the eye and adnexa Diabetic retinopathy H36, E10.3, E11.3, E13.3 MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases Dietary shortage E40-E46 ABL1
NA: NA Upper abdominal bloating NA ACHE
C00-D49: Neoplasms Urethral cancer NA EGFR
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE
H00-H59: Diseases of the eye and adnexa Chronic open-angle glaucoma H40 ADRB1; ADRB1
C00-D49: Neoplasms Hematological malignancies C81-C86 SRC; AURKB; TP53
C00-D49: Neoplasms Hematologic malignancies C81-C86 AKT1
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE
NA: NA Hepatitis C virus infection NA ADORA3
NA: NA Hematopoietic stem cell transplantation NA FLT3
L00-L99: Diseases of the skin and subcutaneous tissue Contact dermatitis L23, L24, L25 PLA2G1B
C00-D49: Neoplasms Colon cancer C50 FLT3; EGFR
C00-D49: Neoplasms Colorectal cancer C18-C21 FLT3; IGF1R; MMP9; EGFR; EGFR; ERBB2; TP53; KDR
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; AXL; IGF1R; IGF1R; ERBB4; CDK2; ATM; EGFR; EGFR; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Obese insulin-resistant disorders E11 CCR2
C00-D49: Neoplasms Osteosarcoma C40-C41 SRC; GSK3B
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis M80-M81, Z79.890 SRC
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 MAOA
E00-E89: Endocrine, nutritional and metabolic diseases Dyslipidaemias E78 HMGCR
NA: NA Early satiation associated with functional dyspepsia NA ACHE
H00-H59: Diseases of the eye and adnexa Corneal ulcers H16.0 MMP3
K00-K95: Diseases of the digestive system Chemotherapy or radiotherapy-induced mucositis K12.3, R52, G89 HMGCR
N00-N99: Diseases of the genitourinary system Endometriosis N80 CYP19A1
E00-E89: Endocrine, nutritional and metabolic diseases Elevated CRP E78.0 HMGCR
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2
C00-D49: Neoplasms Esophageal cancer C15 EGFR
J00-J99: Diseases of the respiratory system Bronchodilator J45 ADRB1
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 MPO; MAOA; ACHE; ADORA1
G00-G99: Diseases of the nervous system G00-G99 Epilepsy G40 MAOA
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Erectile dysfunction F52.2, N48.4 DRD4
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3; ABL1; CDK2
J00-J99: Diseases of the respiratory system Acute lung injury J80 MAPK14
C00-D49: Neoplasms Acute myeloid leukemia C92.0 FLT3; FLT3; AURKB; TP53; TP53
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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Developer & Maintainer:
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