CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	MIF; ALOX12; HSD17B10; ALOX15; NOX4; POLB;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA7; CA4;
Unclassified	LMNA; FABP3; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	MIF	Macrophage migration inhibitory factor	P14174	CHEMBL2085
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242

Showing 1 to 10 of 26 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.475E-07	1.338E-04	CA12, CA2, CA4, CA7
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	1.982E-07	1.660E-04	ALOX12, CA12, CA2, CA7, FABP3, FABP4, FFAR1, MET, NOX4, NPSR1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.375E-07	2.534E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	1.742E-06	8.822E-04	ALOX12, ALOX15
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	2.035E-06	9.845E-04	ALOX15, AXL, CYP1A1, CYP1B1, FABP4, FFAR4, FLT3, IGF1R, KDR, NOX4
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	4.379E-06	1.703E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.222E-06	1.880E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	5.654E-06	1.986E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	5.796E-06	2.003E-03	ALOX15, FFAR4, KDR, MIF, NOX4
BP	GO:0008152; metabolic process	GO:0072593; reactive oxygen species metabolic process	1.002E-05	3.073E-03	ALOX12, CYP1A1, CYP1B1, NOX4

Showing 1 to 10 of 19 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.278E-09	3.695E-07	CA12, CA2, CA4, CA7
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	3.671E-05	1.285E-03	CYP1A1, CYP1B1, IGF1R
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4.043E-04	9.434E-03	CA2, CA4

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;

Showing 1 to 10 of 79 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Descurainia sophia

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities