Plant Name: Descurainia sophia
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FFAR1; FFAR4; DRD4; | |
| TSHR; NPSR1; CXCR1; | |
| ALPI; TDP1; PLA2G1B; RECQL; MIF; PIK3R1; GLO1; HPGD; MPO; AKR1B1; HSD17B10; ALOX15; ALDH1A1; HSD17B2; ALOX12; NOX4; PYGL; POLB; | |
| GAA; | |
| TRPA1; | |
| AKT1; MET; CSNK2A1; DAPK1; FLT3; NEK6; PKN1; CAMK2B; SRC; IGF1R; PTK2; AURKB; GSK3B; CDK1; PIM1; NUAK1; ALK; AXL; NEK2; KDR; | |
| CA3; CA14; CA7; CA5A; CA1; CA4; CA6; CA2; CA12; CA9; | |
| PPARA; PPARG; PPARD; | |
| NR1I2; | |
| KDM4E; | |
| MAOA; ALOX5; PTGS1; XDH; | |
| MMP13; MMP3; MMP2; MMP9; | |
| BACE1; | |
| TLR2; | |
| STAT6; HIF1A; NFKB1; TP53; | |
| ABCC1; ABCG2; | |
| LMNA; FABP5; FABP2; FABP4; FABP3; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
Showing 1 to 10 of 88 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 5.053E-09 | 1.068E-06 | ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B, TLR2 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 8.270E-08 | 1.354E-05 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.936E-07 | 2.833E-05 | CYP1A2, CYP2C8, CYP3A4, NR1I2 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 7.019E-07 | 8.307E-05 | ALOX12, ALOX15, ALOX5, HPGD |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 8.606E-07 | 9.916E-05 | AKT1, AURKB, CAMK2B, CDK1, GSK3B, NEK6, PKN1, SRC |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 1.486E-06 | 1.594E-04 | AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, PKN1 |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 1.725E-06 | 1.800E-04 | AKT1, FABP3, FFAR1, PPARG, SRC, TLR2 |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 1.809E-06 | 1.876E-04 | CYP1A1, CYP2C8, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0055093; response to hyperoxia | 2.268E-06 | 2.245E-04 | CYP1A1, POLB, PPARG, TP53 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 2.268E-06 | 2.245E-04 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
Showing 1 to 10 of 91 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 7.686E-03 | 1.488E-02 | GAA; AKR1B1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.057E-07 | 4.113E-06 | CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.898E-04 | 7.116E-04 | CYP1A2; XDH |
| hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.036E-02 | 1.964E-02 | MAOA; MIF |
| hsa00360 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 2.494E-03 | 5.682E-03 | MAOA; MIF |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.833E-05 | 1.500E-04 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.528E-02 | 4.136E-02 | GAA; PYGL |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 3.080E-07 | 4.620E-06 | CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; PTGS1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.606E-07 | 4.113E-06 | CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 9.865E-06 | 6.704E-05 | CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
Showing 1 to 10 of 113 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3 |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| C00-D49: Neoplasms | Cancer | C00-C96 | AKT1; MET; TLR2; CSNK2A1; CA1; FLT3; FLT3; MMP2; SRC; IGF1R; PTK2; GSK3B; HIF1A; CDK1; MMP9; NFKB1; PIM1; TP53; CA9; KDR |
| C00-D49: Neoplasms | Multiple myeloma | C90 | SRC; IGF1R |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | AKT1; MET; TLR2; FLT3; MMP2; SRC; IGF1R; PTK2; AURKB; HIF1A; MMP9; TP53; CA9; KDR; KDR; KDR |
Showing 1 to 10 of 180 entries