CMAUP Plant Collective Molecular Activities

Plant Name: Leontice robustum

Taxonomic Information:

Plant ID: NPO12214
Plant Latin Name: Leontice robustum
Taxonomy Genus: Leontice
Taxonomy Family: Berberidaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1;
Enzyme_unclassified	BLM;
Hydrolase	ACHE;
Ionotropic glutamate receptor	GRIA4; GRIK2; GRIA1; GRIK3; GRIK5; GRIK1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIK2	Glutamate receptor ionotropic kainate 2	Q13002	CHEMBL3683
Ionotropic glutamate receptor	GRIA1	Glutamate receptor ionotropic, AMPA 1	P42261	CHEMBL2009
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	8.628E-13	2.087E-09	GRIK1, GRIK2, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	4.883E-12	9.667E-09	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
CC	GO:0044464; cell part	GO:0043204; perikaryon	1.314E-08	1.590E-05	GRIK2, GRIK3, GRIK5, SMN1, SMN2
MF	GO:0005215; transporter activity	GO:0008381; mechanosensitive ion channel activity	6.709E-08	5.217E-05	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	2.741E-07	1.865E-04	GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0098782; mechanosensitived potassium channel activity	1.101E-06	6.145E-04	GRIK1, GRIK2, GRIK3, GRIK5
CC	GO:0032991; macromolecular complex	GO:0032983; kainate selective glutamate receptor complex	1.463E-06	7.584E-04	GRIK2, GRIK5
BP	GO:0032501; multicellular organismal process	GO:0007399; nervous system development	2.276E-06	1.078E-03	ACHE, GRIK1, SMN1, SMN2, TSHR
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	2.924E-06	1.355E-03	GRIA1, GRIA4
MF	Unclassified;	GO:0004872; receptor activity	3.348E-06	1.488E-03	ADORA3, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TSHR
CC	GO:0030054; cell junction	GO:0030054; cell junction	8.594E-06	3.283E-03	ACHE, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
CC	GO:0044464; cell part	GO:0043005; neuron projection	1.079E-05	3.981E-03	GRIA1, GRIA4, GRIK3, GRIK5, SMN1, SMN2
CC	GO:0044456; synapse part	GO:0043195; terminal bouton	1.118E-05	4.056E-03	GRIK2, GRIK3, GRIK5
BP	GO:0051179; localization	GO:0034220; ion transmembrane transport	1.902E-05	6.573E-03	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
MF	GO:0005488; binding	GO:0030165; PDZ domain binding	2.994E-05	9.877E-03	GRIA1, GRIK2, GRIK5
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	1.125E-15	1.225E-11	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	9.524E-15	6.663E-11	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0051967; negative regulation of synaptic transmission, glutamatergic	4.417E-05	1.374E-02	GRIK2, GRIK3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3.421E-12	9.578E-11	GRIA1, GRIK5, ADORA3, GRIK3, GRIK1, GRIK2, TSHR, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	8.688E-11	1.216E-09	GRIA1, GRIK5, GRIK3, GRIK1, GRIK2, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	3.258E-04	2.447E-03	GRIA1, TSHR, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	3.496E-04	2.447E-03	GRIA1, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	9.802E-04	5.489E-03	GRIA1, GRIA4
09150 Organismal Systems	09159 Environmental adaptation	hsa04713	Circadian entrainment	1.958E-03	8.835E-03	GRIA1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	2.209E-03	8.835E-03	GRIA1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	3.571E-03	1.250E-02	GRIA1, GRIA4
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	6.252E-03	1.945E-02	SMN2, SMN1
09120 Genetic Information Processing	09124 Replication and repair	hsa03440	Homologous recombination	2.012E-02	5.633E-02	BLM

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; GRIK1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	GRIK1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; ADORA3;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRIK1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases