Plant Name: Leontice robustum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005215; transporter activity | GO:0015277; kainate selective glutamate receptor activity | 8.628E-13 | 2.087E-09 | GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0023052; signaling | GO:0060079; excitatory postsynaptic potential | 4.883E-12 | 9.667E-09 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 1.314E-08 | 1.590E-05 | GRIK2, GRIK3, GRIK5, SMN1, SMN2 |
| MF | GO:0005215; transporter activity | GO:0008381; mechanosensitive ion channel activity | 6.709E-08 | 5.217E-05 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0044456; synapse part | GO:0045211; postsynaptic membrane | 2.741E-07 | 1.865E-04 | GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| MF | Unclassified; | GO:0099600; transmembrane receptor activity | 6.554E-07 | 3.756E-04 | ADORA3, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TSHR |
| MF | GO:0005215; transporter activity | GO:0098782; mechanosensitived potassium channel activity | 1.101E-06 | 6.145E-04 | GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0032991; macromolecular complex | GO:0032983; kainate selective glutamate receptor complex | 1.463E-06 | 7.584E-04 | GRIK2, GRIK5 |
| BP | GO:0032501; multicellular organismal process | GO:0007399; nervous system development | 2.276E-06 | 1.078E-03 | ACHE, GRIK1, SMN1, SMN2, TSHR |
| MF | GO:0005215; transporter activity | GO:0004971; AMPA glutamate receptor activity | 2.924E-06 | 1.355E-03 | GRIA1, GRIA4 |
| MF | Unclassified; | GO:0004872; receptor activity | 3.348E-06 | 1.488E-03 | ADORA3, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TSHR |
| CC | GO:0030054; cell junction | GO:0030054; cell junction | 8.594E-06 | 3.283E-03 | ACHE, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0044464; cell part | GO:0043005; neuron projection | 1.079E-05 | 3.981E-03 | GRIA1, GRIA4, GRIK3, GRIK5, SMN1, SMN2 |
| CC | GO:0044456; synapse part | GO:0043195; terminal bouton | 1.118E-05 | 4.056E-03 | GRIK2, GRIK3, GRIK5 |
| BP | GO:0051179; localization | GO:0034220; ion transmembrane transport | 1.902E-05 | 6.573E-03 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| MF | GO:0005488; binding | GO:0030165; PDZ domain binding | 2.994E-05 | 9.877E-03 | GRIA1, GRIK2, GRIK5 |
| MF | GO:0005215; transporter activity | GO:0005234; extracellularly glutamate-gated ion channel activity | 1.125E-15 | 1.225E-11 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0009987; cellular process | GO:0035235; ionotropic glutamate receptor signaling pathway | 9.524E-15 | 6.663E-11 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 3.421E-12 | 9.578E-11 | GRIA1; GRIK5; ADORA3; GRIK3; GRIK1; GRIK2; TSHR; GRIA4 |
| hsa04724 | Glutamatergic synapse_Homo sapiens_hsa04724 | 8.688E-11 | 1.216E-09 | GRIA1; GRIK5; GRIK3; GRIK1; GRIK2; GRIA4 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 3.258E-04 | 2.447E-03 | GRIA1; TSHR; GRIA4 |
| hsa05033 | Nicotine addiction_Homo sapiens_hsa05033 | 3.496E-04 | 2.447E-03 | GRIA1; GRIA4 |
| hsa05031 | Amphetamine addiction_Homo sapiens_hsa05031 | 9.802E-04 | 5.489E-03 | GRIA1; GRIA4 |
| hsa04713 | Circadian entrainment_Homo sapiens_hsa04713 | 1.958E-03 | 8.835E-03 | GRIA1; GRIA4 |
| hsa04723 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.209E-03 | 8.835E-03 | GRIA1; GRIA4 |
| hsa04728 | Dopaminergic synapse_Homo sapiens_hsa04728 | 3.571E-03 | 1.250E-02 | GRIA1; GRIA4 |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 6.252E-03 | 1.945E-02 | SMN2; SMN1 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1 |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1 |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | GRIK1; ACHE |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ADORA3; ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | GRIK1; GRIK1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | ADORA3 |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| NA: NA | Hepatitis C virus infection | NA | ADORA3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ADORA3 |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; ACHE; ACHE |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | ADORA3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | GRIA1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ADORA3 |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
| NA: NA | Upper abdominal bloating | NA | ACHE |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Convulsions | R56.0 | GRIA1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | GRIA1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | GRIA4; ACHE |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| C00-D49: Neoplasms | Cancer | C00-C96 | ADORA3; ACHE |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | GRIK1 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | GRIK1 |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | GRIK1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE |