CMAUP Plant Collective Molecular Activities

Plant Name: Illicium difengpi

Taxonomic Information:

Plant ID: NPO11871
Plant Latin Name: Illicium difengpi
Taxonomy Genus: Illicium
Taxonomy Family: Schisandraceae

Plant External Links:

NCBI TaxonomyDB: 124772
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; GPBAR1; CNR2;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALOX12; IDH1; GFER; AKR1B10; ALOX15; USP2;
Transcription Factor	TP53;
Unclassified	LMNA; MAPT;
Transferase	FASN;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP3A4; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	IDH1	Isocitrate dehydrogenase [NADP] cytoplasmic	O75874	CHEMBL2007625
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transferase	FASN	Fatty acid synthase	P49327	CHEMBL4158
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.287E-11	4.980E-07	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	7.512E-10	8.178E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	5.894E-09	2.139E-05	CYP1A2, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.642E-08	7.149E-05	ALOX12, ALOX15, CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.760E-07	2.395E-04	CYP1A2, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.203E-07	2.822E-04	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	3.222E-07	3.692E-04	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.461E-07	3.769E-04	AKR1B10, CYP1A2, CYP2C19, CYP2C9, CYP3A4, NR1H4
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	1.356E-06	1.094E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	1.356E-06	1.094E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.934E-06	1.504E-03	CYP1A2, CYP2C19, CYP2C9
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.066E-06	2.606E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	4.066E-06	2.606E-03	CNR1, CNR2
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	4.066E-06	2.606E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	4.066E-06	2.606E-03	ALOX12, ALOX15
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.066E-06	2.606E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	8.126E-06	4.782E-03	CNR1, CNR2
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	9.344E-06	4.787E-03	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	8.614E-06	4.787E-03	CYP2C19, CYP2C9, CYP3A4
CC	GO:0044464; cell part	GO:0043204; perikaryon	9.673E-06	4.787E-03	CNR2, MAPK1, SMN1, SMN2
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	1.353E-05	6.406E-03	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0020037; heme binding	1.477E-05	6.845E-03	CYP1A2, CYP2C19, CYP2C9, CYP3A4
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	8.887E-05	3.024E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	1.049E-04	3.462E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.472E-10	1.958E-08	CYP2C9, CYP1A2, ALOX15, CYP3A4, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.563E-07	1.039E-05	CYP2C9, ALOX15, MAPK1, ALOX12, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	7.092E-07	3.144E-05	CYP2C9, ALOX15, ALOX12, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.093E-06	3.635E-05	CYP2C9, CYP1A2, CYP3A4, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.828E-06	1.070E-04	CYP2C9, AKR1B10, FASN, IDH1, CYP1A2, ALOX15, ALOX12, CYP2C19, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.190E-06	5.825E-05	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	6.066E-05	1.008E-03	IDH1, MAPK1, TP53
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.539E-05	1.008E-03	CYP2C9, CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.840E-05	1.159E-03	CYP2C9, CYP1A2, CYP3A4
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	5.365E-04	6.487E-03	LMNA, MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	5.040E-04	6.487E-03	MAPK1, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TP53;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases