Plant Name: Ligularia macrophylla
Taxonomic Information:
Plant ID: NPO1183
Plant Latin Name: Ligularia macrophylla
Taxonomy Genus: Ligularia
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FFAR1; FFAR4; | |
| TSHR; | |
| TDP1; ALOX15; ALDH1A1; HPGD; | |
| PPARD; PPARA; PPARG; | |
| NR1I2; | |
| PTGS1; | |
| FABP3; GLI2; GLI1; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
| Nuclear hormone receptor subfamily 1 group I | NR1I2 | Pregnane X receptor | O75469 | CHEMBL3401 |
| Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | GLI2 | Zinc finger protein GLI2 | P10070 | CHEMBL5119 |
| Unclassified | GLI1 | Zinc finger protein GLI1 | P08151 | CHEMBL5461 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 6.503E-08 | 2.781E-04 | NR1I2, PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 1.390E-07 | 3.783E-04 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 2.332E-07 | 4.615E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0032502; developmental process | GO:0060032; notochord regression | 6.433E-07 | 8.755E-04 | GLI1, GLI2 |
| BP | GO:0032502; developmental process | GO:0007418; ventral midline development | 1.929E-06 | 2.211E-03 | GLI1, GLI2 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 2.053E-06 | 2.235E-03 | FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 3.348E-06 | 3.170E-03 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0023052; signaling | GO:0021938; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation | 3.856E-06 | 3.359E-03 | GLI1, GLI2 |
| BP | GO:0032502; developmental process | GO:0021696; cerebellar cortex morphogenesis | 6.423E-06 | 4.512E-03 | GLI1, GLI2 |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 6.423E-06 | 4.512E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 7.636E-06 | 5.039E-03 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 9.631E-06 | 5.519E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 9.631E-06 | 5.519E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 9.631E-06 | 5.519E-03 | ALOX15, HPGD |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 9.631E-06 | 5.519E-03 | FABP3, PPARG |
| BP | GO:0032501; multicellular organismal process | GO:0007507; heart development | 1.064E-05 | 5.779E-03 | GLI2, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 1.088E-05 | 5.779E-03 | NR1I2, PPARA, PPARD, PPARG |
| MF | Unclassified; | GO:0004872; receptor activity | 1.239E-05 | 6.274E-03 | FFAR1, FFAR4, HPGD, NR1I2, PPARA, PPARD, PPARG, TSHR |
| MF | GO:0060089; molecular transducer activity | GO:0004955; prostaglandin receptor activity | 2.884E-05 | 1.185E-02 | HPGD, PPARG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 2.288E-07 | 7.780E-06 | FABP3, PPARG, PPARA, PPARD |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 2.303E-04 | 3.916E-03 | PPARG, GLI1, PPARD, GLI2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 4.939E-04 | 5.106E-03 | PPARA, GLI1, TSHR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 9.011E-04 | 5.106E-03 | TSHR, PTGS1 |
| 09160 Human Diseases | 09161 Cancers | hsa05217 | Basal cell carcinoma | 8.693E-04 | 5.106E-03 | GLI1, GLI2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04340 | Hedgehog signaling pathway | 7.188E-04 | 5.106E-03 | GLI1, GLI2 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.103E-03 | 5.359E-03 | ALOX15, PTGS1 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 3.543E-03 | 1.506E-02 | ALOX15, PTGS1 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 8.897E-03 | 3.361E-02 | HPGD, PPARG |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 2.296E-02 | 7.096E-02 | PPARG |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
