Plant Name: Ligularia macrophylla
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 6.503E-08 | 2.781E-04 | NR1I2, PPARA, PPARD, PPARG |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 1.390E-07 | 3.783E-04 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 2.332E-07 | 4.615E-04 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0032502; developmental process | GO:0060032; notochord regression | 6.433E-07 | 8.755E-04 | GLI1, GLI2 |
| BP | GO:0032502; developmental process | GO:0007418; ventral midline development | 1.929E-06 | 2.211E-03 | GLI1, GLI2 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 2.053E-06 | 2.235E-03 | FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 3.348E-06 | 3.170E-03 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0023052; signaling | GO:0021938; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation | 3.856E-06 | 3.359E-03 | GLI1, GLI2 |
| BP | GO:0032502; developmental process | GO:0021696; cerebellar cortex morphogenesis | 6.423E-06 | 4.512E-03 | GLI1, GLI2 |
| BP | GO:0051179; localization | GO:0010891; negative regulation of sequestering of triglyceride | 6.423E-06 | 4.512E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 7.636E-06 | 5.039E-03 | NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0010887; negative regulation of cholesterol storage | 9.631E-06 | 5.519E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:0010871; negative regulation of receptor biosynthetic process | 9.631E-06 | 5.519E-03 | PPARA, PPARG |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 9.631E-06 | 5.519E-03 | ALOX15, HPGD |
| MF | GO:0005488; binding | GO:0050543; icosatetraenoic acid binding | 9.631E-06 | 5.519E-03 | FABP3, PPARG |
| BP | GO:0032501; multicellular organismal process | GO:0007507; heart development | 1.064E-05 | 5.779E-03 | GLI2, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 1.088E-05 | 5.779E-03 | NR1I2, PPARA, PPARD, PPARG |
| MF | Unclassified; | GO:0004872; receptor activity | 1.239E-05 | 6.274E-03 | FFAR1, FFAR4, HPGD, NR1I2, PPARA, PPARD, PPARG, TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.288E-07 | 7.780E-06 | FABP3; PPARG; PPARA; PPARD |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 2.303E-04 | 3.916E-03 | PPARG; GLI1; PPARD; GLI2 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 4.939E-04 | 5.106E-03 | PPARA; GLI1; TSHR |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 9.011E-04 | 5.106E-03 | TSHR; PTGS1 |
| hsa05217 | Basal cell carcinoma_Homo sapiens_hsa05217 | 8.693E-04 | 5.106E-03 | GLI1; GLI2 |
| hsa04340 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 7.188E-04 | 5.106E-03 | GLI1; GLI2 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.103E-03 | 5.359E-03 | ALOX15; PTGS1 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 3.543E-03 | 1.506E-02 | ALOX15; PTGS1 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 8.897E-03 | 3.361E-02 | HPGD; PPARG |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| S00-T88: Injury, poisoning and certain other consequences of external causes | Postoperative inflammation | T81 | PTGS1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | PTGS1 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PPARG; PPARG |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | PTGS1 |
| NA: NA | Dyslipidemia | NA | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | FFAR1 |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARG; PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PPARG; PPARD; PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | PTGS1 |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | PTGS1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Nicotine dependence | F17 | PPARG |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Drug abuse | F10-F19 | PPARG |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dietary shortage | E40-E46 | PTGS1 |
| NA: NA | Rheumatold arthritis | NA | PTGS1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | PTGS1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | PTGS1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | PTGS1 |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | PTGS1 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTGS1 |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | PTGS1; PPARG |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PTGS1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | FFAR1; PPARG; PPARG; PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARG; PPARD |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| NA: NA | Miosis during ocular surgery | NA | PTGS1 |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | PPARG |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | FFAR1; PPARG |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | PPARD; NR1I2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | PPARG |