CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR7; HTR2B; DRD1; HTR6; HCAR2; HTR1A; HTR5A;
Enzyme_unclassified	TDP1; CDA;
Lyase	CA2; CA1; CA7; CA12; CA9; CA14;
Metallo protease	MMP2; MMP9;
Bromodomain	CREBBP;
Unclassified	F3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	CREBBP	CREB-binding protein	Q92793	CHEMBL5747
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333

Showing 1 to 10 of 19 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.599E-12	2.830E-08	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	2.182E-11	6.786E-08	HTR1A, HTR2B, HTR5A, HTR6, HTR7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.921E-10	4.348E-07	CA1, CA12, CA2, CA7, CA9
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	3.225E-09	4.682E-06	HTR1A, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.748E-06	2.494E-03	CA2, CA7
BP	Unclassified;	GO:0042310; vasoconstriction	2.901E-06	2.527E-03	HTR1A, HTR2B, HTR7
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	5.820E-06	4.224E-03	DRD1, HTR1A, HTR2B, HTR7
BP	GO:0032501; multicellular organismal process	GO:0006939; smooth muscle contraction	1.357E-05	7.286E-03	DRD1, HTR2B, HTR7
CC	GO:0016020; membrane	GO:0005886; plasma membrane	3.551E-06	2.896E-03	CA12, CA14, CA2, CA9, DRD1, F3, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, MMP2, TDP1
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	2.182E-11	6.786E-08	HTR1A, HTR2B, HTR5A, HTR6, HTR7

Showing 1 to 10 of 14 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.757E-15	2.104E-13	CA12, CA1, CA2, CA7, CA9, CA14
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.559E-07	2.911E-06	HTR6, HTR7, HTR1A, HTR2B, DRD1, HTR5A
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	5.863E-07	8.209E-06	HTR6, HTR7, HTR2B, DRD1, HTR5A
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	9.628E-07	1.078E-05	HCAR2, CREBBP, HTR6, HTR1A, DRD1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	5.498E-08	1.539E-06	HTR6, HTR7, HTR1A, HTR2B, HTR5A
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	6.858E-04	6.401E-03	MMP2, MMP9

Showing 1 to 6 of 6 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B;
C00-D49: Neoplasms	Chronic myeloid leukemia	NA	CREBBP;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2; F3;
C00-D49: Neoplasms	Cancer	C00-C96	MMP9; MMP2; CA1; CA9;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; CDA; MMP2; CA9;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Renealmia alpinia

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities