CMAUP Plant Collective Molecular Activities

Plant Name: Renealmia alpinia

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR7; HTR5A; DRD1; HCAR2; HTR2B; HTR1A; HTR6;
Hydrolase	GAA;
Enzyme_unclassified	TDP1; CDA; HKDC1; HPGD; USP2;
Lyase	CA2; CA1; CA12; CA9; CA7; CA5A; CA3; CA14; CA5B; CA6;
Metallo protease	MMP9; MMP1; MMP2;
Bromodomain	CREBBP;
SLC superfamily of solute carriers	SLC28A1; SLC28A3;
Unclassified	HTT; LMNA; F3; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP3A4; CYP1A2;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	CREBBP	CREB-binding protein	Q92793	CHEMBL5747
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
SLC superfamily of solute carriers	SLC28A1	Sodium/nucleoside cotransporter 1	O00337	CHEMBL5551
SLC superfamily of solute carriers	SLC28A3	Solute carrier family 28 member 3	Q9HAS3	CHEMBL5707
Small molecule receptor (family A GPCR)	HTR7	Serotonin 7 (5-HT7) receptor	P34969	CHEMBL3155
Small molecule receptor (family A GPCR)	HTR5A	Serotonin 5a (5-HT5a) receptor	P47898	CHEMBL3426
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Small molecule receptor (family A GPCR)	HTR2B	Serotonin 2b (5-HT2b) receptor	P41595	CHEMBL1833
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Small molecule receptor (family A GPCR)	HTR6	Serotonin 6 (5-HT6) receptor	P50406	CHEMBL3371
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.853E-11	2.138E-07	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, CDA, CREBBP, MMP1, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	6.975E-10	1.266E-06	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	6.975E-10	1.266E-06	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0005488; binding	GO:0051378; serotonin binding	3.321E-09	4.520E-06	HTR1A, HTR2B, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	2.375E-08	2.722E-05	HTR1A, HTR5A, HTR7
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.184E-07	1.121E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.816E-25	8.310E-21	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.293E-06	1.005E-03	CYP1A2, CYP2D6, CYP3A4
MF	GO:0005215; transporter activity	GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity	3.377E-06	2.372E-03	SLC28A1, SLC28A3
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	8.935E-06	5.450E-03	HPGD, MMP2, MMP9
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	1.012E-05	5.450E-03	SLC28A1, SLC28A3
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.012E-05	5.450E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.012E-05	5.450E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	1.012E-05	5.450E-03	SLC28A1, SLC28A3
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.026E-05	5.450E-03	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.022E-05	9.570E-03	CYP1A2, CYP3A4
BP	Unclassified;	GO:0042310; vasoconstriction	2.101E-05	9.735E-03	HTR1A, HTR2B, HTR7
BP	GO:0009987; cellular process	GO:0007187; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	2.147E-05	9.738E-03	DRD1, HTR1A, HTR5A, HTR6, HTR7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.043E-19	3.313E-15	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.320E-18	4.529E-14	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Chronic myeloid leukemia	NA	CREBBP
NA: NA	Peripheral sensory neuropathies	NA	HTR1A
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B
C00-D49: Neoplasms	Breast cancer	C50	CA9
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR6
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR1A; HTR1A; MAPT; HTR6; HTR6; HTR6
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1; HTR1A
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1; HTR6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR1A; HTR2B
NA: NA	Anxiety disorders	NA	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A; HTR1A
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
NA: NA	Social phobia	NA	HTR1A
NA: NA	Bulimia nervosa	NA	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; HTR1A; HTR6; HTR6
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2; F3
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; MMP9; MMP2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1; HTR1A
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1; HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	HCAR2
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HCAR2
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	HTR6
NA: NA	Edema	NA	CA2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; MMP9; MMP2; CDA
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR7
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A; HTR1A
NA: NA	Episode	NA	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1; HCAR2
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A
NA: NA	Schizoaffective disorder	NA	HTR1A
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	HTR2B
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HTR2B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR6
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT; HTR6
C00-D49: Neoplasms	Renal cancer	C64	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; HTR1A
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR1A
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR7; DRD1; HTR1A; HTR1A; HTR6
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR1A; HTR2B; CYP2D6
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR7; HCAR2; HTR1A; HTR1A
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	CREBBP
NA: NA	Cervical dystonia	NA	HTR1A
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1; HTR1A; MAPT; HTR6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2; CYP2D6

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases