CMAUP Plant Collective Molecular Activities

Plant Name: Veronicastrum sibiricum

Taxonomic Information:

Plant ID: NPO11138
Plant Latin Name: Veronicastrum sibiricum
Taxonomy Genus: Veronicastrum
Taxonomy Family: Plantaginaceae

Plant External Links:

NCBI TaxonomyDB: 74695
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; CES2;
Protein Phosphatase	PTPN11; PTPN6;
Unclassified	MAPT; LMNA;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	CES2	Carboxylesterase 2	O00748	CHEMBL3180
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Protein Phosphatase	PTPN11	Protein-tyrosine phosphatase 2C	Q06124	CHEMBL3864
Protein Phosphatase	PTPN6	Protein-tyrosine phosphatase 1C	P29350	CHEMBL3166
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0033277; abortive mitotic cell cycle	1.126E-07	2.451E-03	PTPN11, PTPN6
BP	GO:0002376; immune system process	GO:0035855; megakaryocyte development	1.348E-05	1.283E-01	PTPN11, PTPN6
BP	GO:0022610; biological adhesion	GO:0033628; regulation of cell adhesion mediated by integrin	8.723E-05	2.374E-01	PTPN11, PTPN6
BP	GO:0009987; cellular process	GO:0060338; regulation of type I interferon-mediated signaling pathway	1.156E-04	2.714E-01	PTPN11, PTPN6
BP	GO:0051179; localization	GO:0060341; regulation of cellular localization	1.371E-04	2.714E-01	LMNA, MAPT, PTPN11, PTPN6
MF	GO:0003824; catalytic activity	GO:0042578; phosphoric ester hydrolase activity	2.232E-04	3.758E-01	PTPN11, PTPN6, TDP1
MF	GO:0003824; catalytic activity	GO:0004725; protein tyrosine phosphatase activity	5.699E-04	4.782E-01	PTPN11, PTPN6
MF	GO:0003824; catalytic activity	GO:0047374; methylumbelliferyl-acetate deacetylase activity	1.087E-03	5.772E-01	CES2
CC	GO:0043226; organelle	GO:0005634; nucleus	1.940E-03	7.162E-01	L3MBTL1, LMNA, MAPT, PTPN11, PTPN6, TDP1
CC	GO:0044464; cell part	GO:0030673; axolemma	5.785E-03	9.543E-01	MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09151 Immune system	hsa04650	Natural killer cell mediated cytotoxicity	9.289E-04	1.523E-02	PTPN6, PTPN11
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	1.269E-03	1.523E-02	PTPN6, PTPN11
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.082E-03	1.665E-02	PTPN6, PTPN11
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.599E-02	5.124E-02	CES2
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	2.288E-02	5.124E-02	PTPN11
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2.356E-02	5.124E-02	PTPN11
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	2.528E-02	5.124E-02	PTPN6
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	2.528E-02	5.124E-02	PTPN11
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	2.425E-02	5.124E-02	PTPN11
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	2.562E-02	5.124E-02	LMNA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases