CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	ALPL; TDP1; ALOX12; HSD17B10; NOX4; POLB;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA12; CA7; CA4;
Lysine demethylase	KDM4E;
Transcription Factor	NFKB1;
Transferase	FUT7;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729

Showing 1 to 10 of 23 entries

Previous1 2 3Next

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	2.977E-07	5.893E-04	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, NFKB1, PIM1
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	2.293E-06	2.497E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	2.965E-06	2.934E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.026E-05	7.449E-03	CA12, CA4, CA7
BP	GO:0065007; biological regulation	GO:0042592; homeostatic process	1.402E-05	8.723E-03	ALOX12, AXL, CA12, CA7, FLT3, MET, NOX4, NPSR1, POLB
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.647E-07	1.034E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0008144; drug binding	1.237E-05	8.165E-03	AURKB, AXL, CDK1, CYP1B1, FLT3, IGF1R, KDR, MET, NOX4, PIM1

Showing 1 to 7 of 7 entries

Previous1Next

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.939E-07	8.760E-05	CA12, CA4, CA7
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.208E-04	2.959E-03	KDR, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	5.690E-04	9.293E-03	KDR, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.733E-05	1.606E-03	FLT3, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	4.915E-05	1.606E-03	FLT3, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	3.377E-04	6.619E-03	PIM1, CYP1B1, MET, NFKB1

Showing 1 to 6 of 6 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;

Showing 1 to 10 of 71 entries

Previous1 2 3 4 5…8Next

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Acanthospermum glabratum

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities