Plant Name: Acanthospermum glabratum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CXCR1; NPSR1; | |
| DRD4; | |
| TDP1; RECQL; ALPI; ALPL; PLA2G1B; P4HB; PIK3R1; GLO1; HPGD; MPO; AKR1B1; HSD17B2; ALOX12; NOX4; ALOX15; ALDH1A1; HSD17B10; PYGL; POLB; | |
| GAA; | |
| DAPK1; AKT1; CAMK2B; MET; FLT3; NEK6; CDK1; PIM1; NEK2; AXL; IGF1R; NUAK1; ALK; KDR; GSK3B; SRC; PTK2; AURKB; PKN1; CSNK2A1; | |
| CA2; CA12; CA1; CA9; CA5B; CA5A; CA3; CA7; CA4; CA6; CA14; | |
| ALOX5; MAOA; XDH; | |
| KDM4E; | |
| BACE1; | |
| MMP13; MMP9; MMP3; MMP2; | |
| HIF1A; TP53; NFKB1; STAT6; | |
| FUT7; | |
| ABCG2; ABCC1; | |
| LMNA; MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Showing 1 to 10 of 78 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 5.072E-08 | 1.125E-05 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 1.476E-07 | 2.869E-05 | ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 3.375E-07 | 5.638E-05 | AKT1, AURKB, CAMK2B, CDK1, GSK3B, NEK6, PKN1, SRC |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 4.315E-07 | 6.960E-05 | ALOX12, ALOX15, ALOX5, HPGD |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 7.270E-07 | 1.070E-04 | AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, PKN1 |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 1.256E-06 | 1.709E-04 | CYP1A1, CYP2C8, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.397E-06 | 1.855E-04 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| BP | GO:0050896; response to stimulus | GO:0009725; response to hormone | 2.197E-06 | 2.737E-04 | AKR1B1, AKT1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, FLT3, HPGD, NFKB1, PIK3R1, PLA2G1B, SRC |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 3.952E-06 | 4.506E-04 | AKT1, HIF1A, LMNA, P4HB, SRC, TP53 |
| BP | GO:0032502; developmental process | GO:0007568; aging | 4.230E-06 | 4.747E-04 | AKT1, AURKB, CDK1, CYP1A1, MPO, NOX4, POLB, TP53 |
Showing 1 to 10 of 73 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 6.086E-03 | 1.352E-02 | GAA; AKR1B1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 9.967E-08 | 2.243E-06 | CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.490E-04 | 5.608E-04 | CYP1A2; XDH |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.758E-05 | 1.055E-04 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.018E-02 | 3.396E-02 | GAA; PYGL |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 4.309E-06 | 4.082E-05 | CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 8.743E-08 | 2.243E-06 | CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4 |
| hsa00790 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.326E-03 | 3.671E-03 | ALPL; ALPI |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 5.451E-06 | 4.672E-05 | CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.847E-23 | 3.325E-21 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
Showing 1 to 10 of 114 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3 |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MET; AXL; KDR; IGF1R; IGF1R |
| C00-D49: Neoplasms | Multiple myeloma | C90 | SRC; IGF1R |
Showing 1 to 10 of 161 entries