CMAUP Plant Collective Molecular Activities

Plant Name: Melissa officinalis

Taxonomic Information:

Plant ID: NPO10932
Plant Latin Name: Melissa officinalis
Taxonomy Genus: Melissa
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 39338
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; Israel; Italy; Portugal; India; Jordan; Chile; China; Argentina

Traditional Medicine System:

TCM; Siddha

Medicinal Functions:

Antianxiety; Antibacterial; Antidepressant; Antiemetic; Antispasmodic; Antiviral; Aromatherapy; Carminative; Diaphoretic; Digestive; Emmenagogue; Febrifuge; Sedative; Tonic

Geographical Distribution:

Turkey; Israel; Italy; Portugal; India; China; Chile; Jordan; Argentina

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	TDP1; PLA2G1B; RECQL; PKM; AKR1B10; AKR1B1; POLB; APEX1;
Hydrolase	GAA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP1;
Unclassified	MCL1; TTR;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	TTR	Transthyretin	P02766	CHEMBL3194

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	9.167E-07	9.980E-03	APEX1, POLB
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	2.748E-06	1.050E-02	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	2.748E-06	1.050E-02	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	5.331E-06	1.495E-02	AKR1B1, APEX1, LMNA, MAPT, MCL1, POLB, PTPN1, RECQL, TDP1
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	5.494E-06	1.495E-02	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.445E-05	2.860E-02	NR1H4, PTPN1, PTPN2
MF	GO:0005488; binding	GO:0070324; thyroid hormone binding	1.919E-05	3.276E-02	PKM, TTR
MF	GO:0003824; catalytic activity	GO:0042578; phosphoric ester hydrolase activity	2.220E-05	3.276E-02	APEX1, CDC25B, PTPN1, PTPN2, TDP1
MF	GO:0005488; binding	GO:0032052; bile acid binding	3.286E-05	3.578E-02	NR1H4, PLA2G1B

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.904E-06	1.336E-04	AKR1B10, GAA, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5.284E-04	6.077E-03	AKR1B10, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4.170E-04	6.077E-03	AKR1B10, AKR1B1
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	4.436E-04	6.077E-03	POLB, APEX1
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	1.417E-03	1.303E-02	AKR1B10, AKR1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	5.067E-03	3.885E-02	PKM, AKR1B10, PLA2G1B, GAA, AKR1B1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.695E-03	5.057E-02	LMNA, MCL1
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	9.710E-03	5.583E-02	PTPN2, MCL1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.594E-02	8.148E-02	POLB, PKM
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	2.401E-02	1.004E-01	MAPT, CDC25B

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PKM;
C00-D49: Neoplasms	Solid tumours	C00-D48	PKM;
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases