CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	9.167E-07	9.980E-03	APEX1, POLB

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	2.904E-06	1.336E-04	AKR1B10; GAA; AKR1B1
hsa00040	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	5.284E-04	6.077E-03	AKR1B10; AKR1B1
hsa00051	Fructose and mannose metabolism_Homo sapiens_hsa00051	4.170E-04	6.077E-03	AKR1B10; AKR1B1
hsa03410	Base excision repair_Homo sapiens_hsa03410	4.436E-04	6.077E-03	POLB; APEX1
hsa00561	Glycerolipid metabolism_Homo sapiens_hsa00561	1.417E-03	1.303E-02	AKR1B10; AKR1B1
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	5.067E-03	3.885E-02	PKM; AKR1B10; PLA2G1B; GAA; AKR1B1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
I00-I99: Diseases of the circulatory system	Cardiomyopathy	I42.0	TTR
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	TTR
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; AKR1B1
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PKM
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1
E00-E89: Endocrine, nutritional and metabolic diseases	TTR amyloidosis	E85	TTR
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1; PLA2G1B
C00-D49: Neoplasms	Solid tumours	C00-D48	PKM
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B; MCL1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1; AKR1B1; PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1
C00-D49: Neoplasms	Ocular cancer	C69	APEX1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
NA: NA	Colour dead tissues	NA	PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Melissa officinalis

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases