CMAUP Plant Collective Molecular Activities

Plant Name: Cistanche deserticola

Taxonomic Information:

Plant ID: NPO10680
Plant Latin Name: Cistanche deserticola
Taxonomy Genus: Cistanche
Taxonomy Family: Orobanchaceae

Plant External Links:

NCBI TaxonomyDB: 161395
Plant-of-the-World-Online: 957757-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China; Mongolia

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; ALOX15; HSD17B10;
Protein Kinase	PRKCA;
Lyase	CA2; CA1; CA5B; CA5A; CA6; CA12;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Metallo protease	MMP2; MMP12;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.296E-13	2.392E-09	CA1, CA12, CA2, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.190E-12	6.476E-09	CA1, CA12, CA2, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.747E-12	2.449E-08	CA1, CA12, CA2, CA5A, CA5B, CA6, MMP12, MMP2, PPARA, PPARD, PRKCA
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.555E-16	1.863E-11	CA1, CA12, CA2, CA5A, CA5B, CA6
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.091E-05	1.485E-02	CA1, CA2
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	3.978E-05	4.828E-02	ALOX15, PPARA, PPARD
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	3.991E-05	4.828E-02	PPARA, PPARD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.715E-15	1.561E-13	CA12, CA1, CA5B, CA2, CA5A, CA6
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.724E-04	1.239E-02	ALOX15, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	1.772E-03	2.687E-02	CA2, PRKCA
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.633E-03	2.687E-02	PRKCA, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.543E-03	2.687E-02	PPARA, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.633E-03	2.687E-02	CA2, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	2.664E-03	3.305E-02	MMP2, PRKCA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3.268E-03	3.305E-02	MMP2, PRKCA
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	2.959E-03	3.305E-02	CA2, PRKCA
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	4.430E-03	3.359E-02	MMP2, PRKCA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases