Plant Name: Cistanche deserticola
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.296E-13 | 2.392E-09 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.190E-12 | 6.476E-09 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 6.747E-12 | 2.449E-08 | CA1, CA12, CA2, CA5A, CA5B, CA6, MMP12, MMP2, PPARA, PPARD, PRKCA |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 8.555E-16 | 1.863E-11 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.715E-15 | 1.561E-13 | CA12; CA1; CA5B; CA2; CA5A; CA6 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.724E-04 | 1.239E-02 | ALOX15; CYP3A4 |
| hsa04971 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.772E-03 | 2.687E-02 | CA2; PRKCA |
| hsa04918 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 1.633E-03 | 2.687E-02 | PRKCA; TSHR |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.543E-03 | 2.687E-02 | PPARA; PPARD |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 1.633E-03 | 2.687E-02 | CA2; CYP3A4 |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 2.664E-03 | 3.305E-02 | MMP2; PRKCA |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 3.268E-03 | 3.305E-02 | MMP2; PRKCA |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 4.292E-03 | 3.359E-02 | MMP2; PRKCA; PPARD |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.001E-03 | 3.359E-02 | ALOX15; PRKCA |
| hsa04972 | Pancreatic secretion_Homo sapiens_hsa04972 | 2.959E-03 | 3.305E-02 | CA2; PRKCA |
| hsa04310 | Wnt signaling pathway_Homo sapiens_hsa04310 | 6.348E-03 | 4.444E-02 | PRKCA; PPARD |
| hsa04670 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 4.430E-03 | 3.359E-02 | MMP2; PRKCA |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Ovarian cancer | C56 | MMP2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | MMP2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2 |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | MMP2 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | PPARD; MMP12 |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | MMP12 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MMP12; MMP12 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| I00-I99: Diseases of the circulatory system | Aortic aneurysm | I71 | MMP12 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |
| NA: NA | Edema | NA | CA2 |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PPARD |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MMP2 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA1; MMP2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | MMP2 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| NA: NA | Dyslipidemia | NA | PPARD |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PPARD; PPARD |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | MMP2 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MMP12 |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MMP2 |