CMAUP Plant Collective Molecular Activities

Plant Name: Gentiana lactea

Taxonomic Information:

Plant ID: NPO10647
Plant Latin Name: Gentiana lactea
Taxonomy Genus: Gentiana
Taxonomy Family: Gentianaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Phosphodiesterase 4	PDE4D;
Oxidoreductase	MAOA;
Cysteine protease	CTSV;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CTSV	Cathepsin L2	O60911	CHEMBL3272
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Phosphodiesterase 4	PDE4D	Phosphodiesterase 4D	Q08499	CHEMBL288

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:1901898; negative regulation of relaxation of cardiac muscle	3.106E-04	1.000E+00	PDE4D
BP	GO:0008152; metabolic process	GO:0042420; dopamine catabolic process	1.242E-03	1.000E+00	MAOA
BP	GO:0050896; response to stimulus	GO:0071872; cellular response to epinephrine stimulus	2.018E-03	1.000E+00	PDE4D
BP	GO:0008152; metabolic process	GO:0006198; cAMP catabolic process	2.173E-03	1.000E+00	PDE4D
BP	GO:0008152; metabolic process	GO:0016540; protein autoprocessing	2.173E-03	1.000E+00	CTSV
BP	GO:0022414; reproductive process	GO:0046697; decidualization	3.103E-03	1.000E+00	CTSV
BP	GO:0032501; multicellular organismal process	GO:0006939; smooth muscle contraction	7.437E-03	1.000E+00	PDE4D
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	1.222E-02	1.000E+00	CTSV
BP	GO:0008152; metabolic process	GO:0030814; regulation of cAMP metabolic process	1.791E-02	1.000E+00	PDE4D
BP	GO:0050896; response to stimulus	GO:0071222; cellular response to lipopolysaccharide	1.837E-02	1.000E+00	PDE4D
BP	GO:0050896; response to stimulus	GO:0009267; cellular response to starvation	2.082E-02	1.000E+00	CTSV
BP	GO:0009987; cellular process	GO:0050852; T cell receptor signaling pathway	2.235E-02	1.000E+00	PDE4D
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	3.196E-02	1.000E+00	PDE4D
CC	GO:0044464; cell part	GO:0043204; perikaryon	1.776E-02	1.000E+00	CTSV
MF	GO:0003824; catalytic activity	GO:0008131; primary amine oxidase activity	9.316E-04	1.000E+00	MAOA
MF	GO:0003824; catalytic activity	GO:0004115; 3',5'-cyclic-AMP phosphodiesterase activity	2.328E-03	1.000E+00	PDE4D
MF	GO:0005488; binding	GO:0030552; cAMP binding	3.568E-03	1.000E+00	PDE4D
MF	GO:0003824; catalytic activity	GO:0003824; catalytic activity	2.891E-02	1.000E+00	CTSV, MAOA, PDE4D
MF	GO:0003824; catalytic activity	GO:0004252; serine-type endopeptidase activity	3.803E-02	1.000E+00	CTSV
MF	GO:0005488; binding	GO:0042277; peptide binding	4.105E-02	1.000E+00	CTSV

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00340	Histidine metabolism	3.596E-03	1.924E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	2.548E-03	1.924E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	5.241E-03	1.924E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.988E-03	1.924E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5.988E-03	1.924E-02	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	7.332E-03	1.924E-02	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	1.002E-02	2.063E-02	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00330	Arginine and proline metabolism	7.482E-03	1.924E-02	MAOA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.031E-02	2.063E-02	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	1.359E-02	2.446E-02	PDE4D

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases