CMAUP Plant Collective Molecular Activities

Plant Name: Gentiana lactea

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	PDE4D
J00-J99: Diseases of the respiratory system	Asthma	J45	PDE4D; PDE4D
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	PDE4D; PDE4D; PDE4D
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA
J00-J99: Diseases of the respiratory system	Emphysema	J43	PDE4D
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA; MAOA
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	PDE4D
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	PDE4D

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases