CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	BLM; RECQL;
Protein Kinase	CDK2; AURKB; AURKA; CDK1; CDK4;
Unclassified	MAPT;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	CDK2	Cyclin-dependent kinase 2	P24941	CHEMBL301
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1901796; regulation of signal transduction by p53 class mediator	4.462E-08	1.388E-04	AURKA, AURKB, BLM, CDK2, L3MBTL1
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.300E-06	2.684E-03	CYP2C19, CYP3A4
BP	GO:0009987; cellular process	GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6.787E-06	3.102E-03	AURKA, CDK1, CDK2
BP	GO:0032502; developmental process	GO:0031100; animal organ regeneration	1.255E-05	4.392E-03	AURKA, CDK1, CDK4
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	1.271E-05	4.392E-03	BLM, RECQL
BP	GO:0008152; metabolic process	GO:0031145; anaphase-promoting complex-dependent catabolic process	1.465E-05	4.748E-03	AURKA, AURKB, CDK1
BP	GO:0009987; cellular process	GO:0035690; cellular response to drug	2.007E-05	5.987E-03	BLM, CDK1, CDK2, CDK4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.327E-05	6.581E-03	CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0035404; histone-serine phosphorylation	2.327E-05	6.581E-03	AURKA, AURKB
BP	GO:0051179; localization	GO:0034501; protein localization to kinetochore	2.749E-05	7.469E-03	AURKB, CDK1

Showing 1 to 10 of 23 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.328E-04	1.494E-03	CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7.571E-04	5.678E-03	CYP3A4, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	8.456E-06	3.805E-04	CDK4, CDK2, CDK1
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	4.796E-05	7.369E-04	CDK2, CDK1, AURKA
09140 Cellular Processes	09143 Cell growth and death	hsa04110	Cell cycle	4.913E-05	7.369E-04	CDK4, CDK2, CDK1
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1.519E-03	7.596E-03	CDK2, CDK1
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	2.181E-04	1.963E-03	CDK4, CDK2, CDK1
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	1.173E-03	6.598E-03	CDK4, CDK2
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.067E-03	6.598E-03	CYP3A4, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	2.897E-03	1.304E-02	CDK4, CDK2

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	CDK2;
C00-D49: Neoplasms	Breast cancer	C50	CDK1;
C00-D49: Neoplasms	Solid tumours	C00-D48	CDK2;
C00-D49: Neoplasms	Thymoma	C37, D15.0	CDK2;
C00-D49: Neoplasms	Cancer	C00-C96	CDK2; CDK1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CDK2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1;

Showing 1 to 8 of 8 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aconitum vilmorini

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities