Plant Name: Aconitum vilmorini
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:1901796; regulation of signal transduction by p53 class mediator | 4.462E-08 | 1.388E-04 | AURKA, AURKB, BLM, CDK2, L3MBTL1 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 5.300E-06 | 2.684E-03 | CYP2C19, CYP3A4 |
| BP | GO:0009987; cellular process | GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 6.787E-06 | 3.102E-03 | AURKA, CDK1, CDK2 |
| BP | GO:0032502; developmental process | GO:0031100; animal organ regeneration | 1.255E-05 | 4.392E-03 | AURKA, CDK1, CDK4 |
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 1.271E-05 | 4.392E-03 | BLM, RECQL |
| BP | GO:0008152; metabolic process | GO:0031145; anaphase-promoting complex-dependent catabolic process | 1.465E-05 | 4.748E-03 | AURKA, AURKB, CDK1 |
| BP | GO:0065007; biological regulation | GO:0051338; regulation of transferase activity | 1.483E-05 | 4.748E-03 | AURKB, BLM, CDK1, CDK2, CDK4, MAPT |
| BP | GO:0009987; cellular process | GO:0035690; cellular response to drug | 2.007E-05 | 5.987E-03 | BLM, CDK1, CDK2, CDK4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 2.327E-05 | 6.581E-03 | CYP2C19, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0035404; histone-serine phosphorylation | 2.327E-05 | 6.581E-03 | AURKA, AURKB |
Showing 1 to 10 of 24 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.328E-04 | 1.494E-03 | CYP3A4; CYP2C19 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 7.571E-04 | 5.678E-03 | CYP3A4; CYP2C19 |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 4.913E-05 | 7.369E-04 | CDK4; CDK2; CDK1 |
| hsa04114 | Oocyte meiosis_Homo sapiens_hsa04114 | 4.796E-05 | 7.369E-04 | CDK2; CDK1; AURKA |
| hsa04115 | p53 signaling pathway_Homo sapiens_hsa04115 | 8.456E-06 | 3.805E-04 | CDK4; CDK2; CDK1 |
| hsa04914 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.519E-03 | 7.596E-03 | CDK2; CDK1 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 3.330E-03 | 1.362E-02 | CDK4; CDK2 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 2.897E-03 | 1.304E-02 | CDK4; CDK2 |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 5.285E-03 | 1.982E-02 | CDK2; CDK1 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 6.268E-03 | 2.170E-02 | CDK2; CDK1 |
Showing 1 to 10 of 13 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Small-cell lung cancer | C33-C34 | CDK4 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CDK2 |
| C00-D49: Neoplasms | Breast cancer | C50 | CDK1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CDK2; AURKB; AURKA; CDK4 |
| C00-D49: Neoplasms | Thymoma | C37, D15.0 | CDK2 |
| C00-D49: Neoplasms | Mantle cell lymphoma | C81-C86, C85.7, C90.0, C91-C95 | CDK4 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDK2; AURKA; CDK1; CDK4 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | AURKA; CDK4 |
Showing 1 to 10 of 22 entries