CMAUP Plant Collective Molecular Activities

Plant Name: Rubia tinctorum

Taxonomic Information:

Plant ID: NPO10014
Plant Latin Name: Rubia tinctorum
Taxonomy Genus: Rubia
Taxonomy Family: Rubiaceae

Plant External Links:

NCBI TaxonomyDB: 29802
Plant-of-the-World-Online: 765369-1

Used in Medicines:

Country/Region:

Turkey; Italy; India; Lebanon; Jordan; China

Traditional Medicine System:

Indian Folk; TCM

Medicinal Functions:

Aperient; Astringent; Cholagogue; Diuretic; Emmenagogue

Geographical Distribution:

Turkey; Afghanistan; Italy; Turkmenistan; Lebanon; France; Argentina; Uzbekistan; Iran; Algeria; Jordan; Chile; China; Germany; Kazakhstan; Spain; Ukraine; Netherlands; Libya; Iraq; Morocco; Vietnam; Switzerland; Russia; Bulgaria; Pakistan; Albania; Portugal; Tunisia; Tajikistan; India; United Kingdom; Austria; Greece; Hungary; Cyprus

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; RECQL; ALOX15; HSD17B10; ALOX12; GFER; ALDH1A1;
Miscellaneous ion channel	BCL2;
Protein Kinase	LCK; LIMK1;
Lyase	CA12; CA9; CA7;
Cysteine protease	CASP7; CASP1;
Unclassified	MCL1; NPC1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Protein Kinase	LCK	Tyrosine-protein kinase LCK	P06239	CHEMBL258
Protein Kinase	LIMK1	LIM domain kinase 1	P53667	CHEMBL3836
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	9.167E-07	3.992E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.644E-07	3.992E-03	CA12, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	9.167E-07	3.992E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	2.748E-06	7.481E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	2.748E-06	7.481E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.644E-06	1.229E-02	CA12, CA7, CA9
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	9.151E-06	1.533E-02	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0051434; BH3 domain binding	9.151E-06	1.533E-02	BCL2, MCL1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.042E-05	1.620E-02	CA12, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.901E-07	2.696E-05	CA12, CA7, CA9
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.996E-04	6.268E-03	CASP7, BCL2, MCL1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.419E-04	6.268E-03	CYP1A2, ALOX15
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	1.060E-03	1.348E-02	BCL2, CASP1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.232E-03	1.348E-02	CASP7, CASP1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.563E-03	1.348E-02	ALOX15, ALOX12
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.716E-03	1.348E-02	CYP1A2, ALDH1A1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.277E-03	1.565E-02	CASP7, CASP1
Unclassified	Unclassified	hsa01100	Metabolic pathways	5.067E-03	2.322E-02	CYP1A2, ALOX15, ALDH1A1, ALOX12, HSD17B10
09130 Environmental Information Processing	09132 Signal transduction	hsa04064	NF-kappa B signaling pathway	3.474E-03	2.123E-02	LCK, BCL2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	LCK;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases