Plant Name: Rubia tinctorum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 9.167E-07 | 3.992E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 3.644E-07 | 3.992E-03 | CA12, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 9.167E-07 | 3.992E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 2.748E-06 | 7.481E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 2.748E-06 | 7.481E-03 | ALOX12, ALOX15 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 4.901E-07 | 2.696E-05 | CA12; CA7; CA9 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 2.996E-04 | 6.268E-03 | CASP7; BCL2; MCL1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 3.419E-04 | 6.268E-03 | CYP1A2; ALOX15 |
| hsa05014 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.060E-03 | 1.348E-02 | BCL2; CASP1 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 1.232E-03 | 1.348E-02 | CASP7; CASP1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.563E-03 | 1.348E-02 | ALOX15; ALOX12 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.716E-03 | 1.348E-02 | CYP1A2; ALDH1A1 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 2.277E-03 | 1.565E-02 | CASP7; CASP1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 5.067E-03 | 2.322E-02 | CYP1A2; ALOX15; ALDH1A1; ALOX12; HSD17B10 |
| hsa04064 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 3.474E-03 | 2.123E-02 | LCK; BCL2 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.994E-03 | 2.322E-02 | ALOX15; ALOX12 |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 9.710E-03 | 4.108E-02 | BCL2; MCL1 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 1.092E-02 | 4.290E-02 | CASP7; HSD17B10 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 4.741E-03 | 2.322E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | BCL2 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Advanced melanoma | C43 | BCL2 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Cancer | C00-C96 | BCL2; BCL2; MCL1; CA9 |
| G00-G99: Diseases of the nervous system G00-G99 | Amyotrophic lateral sclerosis | G12.2 | BCL2 |
| C00-D49: Neoplasms | Leukemia | C90-C95 | BCL2 |
| C00-D49: Neoplasms | Prostate cancer | C61 | BCL2 |
| C00-D49: Neoplasms | Breast cancer | C50 | BCL2; CA9 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | BCL2 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | BCL2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | LCK |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2; CA9 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |