Molecular Weight:   | 358.11 |
Volume:   | 351.951 |
LogP:   | 3.305 |
LogD:   | 2.906 |
LogS:   | -4.397 |
# Rotatable Bonds:   | 5 |
TPSA:   | 87.36 |
# H-Bond Aceptor:   | 7 |
# H-Bond Donor:   | 1 |
# Rings:   | 3 |
# Heavy Atoms:   | 7 |
QED Drug-Likeness Score:   | 0.749 |
Synthetic Accessibility Score:   | 2.246 |
Fsp3:   | 0.211 |
Lipinski Rule-of-5:   | Accepted |
Pfizer Rule:   | Accepted |
GSK Rule:   | Accepted |
BMS Rule:   | 0 |
Golden Triangle Rule:   | Accepted |
Chelating Alert:   | 0 |
PAINS Alert:   | 0 |
Caco-2 Permeability:   | -4.704 |
MDCK Permeability:   | 3.5863384255208075e-05 |
Pgp-inhibitor:   | 0.998 |
Pgp-substrate:   | 0.001 |
Human Intestinal Absorption (HIA):   | 0.009 |
20% Bioavailability (F20%):   | 0.003 |
30% Bioavailability (F30%):   | 0.009 |
Blood-Brain-Barrier Penetration (BBB):   | 0.019 |
Plasma Protein Binding (PPB):   | 81.54876708984375% |
Volume Distribution (VD):   | 0.86 |
Pgp-substrate:   | 17.187210083007812% |
CYP1A2-inhibitor:   | 0.873 |
CYP1A2-substrate:   | 0.974 |
CYP2C19-inhibitor:   | 0.744 |
CYP2C19-substrate:   | 0.601 |
CYP2C9-inhibitor:   | 0.699 |
CYP2C9-substrate:   | 0.925 |
CYP2D6-inhibitor:   | 0.381 |
CYP2D6-substrate:   | 0.926 |
CYP3A4-inhibitor:   | 0.756 |
CYP3A4-substrate:   | 0.427 |
Clearance (CL):   | 6.298 |
Half-life (T1/2):   | 0.662 |
hERG Blockers:   | 0.034 |
Human Hepatotoxicity (H-HT):   | 0.161 |
Drug-inuced Liver Injury (DILI):   | 0.963 |
AMES Toxicity:   | 0.47 |
Rat Oral Acute Toxicity:   | 0.146 |
Maximum Recommended Daily Dose:   | 0.132 |
Skin Sensitization:   | 0.141 |
Carcinogencity:   | 0.034 |
Eye Corrosion:   | 0.004 |
Eye Irritation:   | 0.218 |
Respiratory Toxicity:   | 0.26 |
Natural Product ID:   | NPC236769 |
Common Name*:   | Retusin |
IUPAC Name:   | 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,7-dimethoxychromen-4-one |
Synonyms:   | NSC-61837 |
Standard InCHIKey:   | HHGPYJLEJGNWJA-UHFFFAOYSA-N |
Standard InCHI:   | InChI=1S/C19H18O7/c1-22-11-8-12(20)16-15(9-11)26-18(19(25-4)17(16)21)10-5-6-13(23-2)14(7-10)24-3/h5-9,20H,1-4H3 |
SMILES:   | COc1cc(c2c(c1)oc(c1ccc(c(c1)OC)OC)c(c2=O)OC)O |
Synthetic Gene Cluster:   | n.a. |
ChEMBL Identifier:   | CHEMBL77966 |
PubChem CID:   |
5352005 |
Chemical Classification**:   |
|
*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.
Organism ID | Organism Name | Taxonomy Level | Family | SuperKingdom | Isolation Part | Collection Location | Collection Time | Reference |
---|---|---|---|---|---|---|---|---|
NPO1373 | Pulsatilla chinensis | Species | Ranunculaceae | Eukaryota | roots | n.a. | n.a. |
PMID[10514313] |
NPO1373 | Pulsatilla chinensis | Species | Ranunculaceae | Eukaryota | n.a. | root | n.a. |
PMID[10514313] |
NPO27986 | Lonchocarpus chiricanus | Species | Fabaceae | Eukaryota | Root barks | n.a. | n.a. |
PMID[11421729] |
NPO20244 | Melicope semecarpifolia | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[11575945] |
NPO1373 | Pulsatilla chinensis | Species | Ranunculaceae | Eukaryota | roots | n.a. | n.a. |
PMID[11575962] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | stem | n.a. |
PMID[12575075] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | leaf | n.a. |
PMID[12575075] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | whole plant | n.a. |
PMID[15577255] |
NPO27695 | Centaurea sonchifolia | Species | n.a. | n.a. | n.a. | n.a. | n.a. |
PMID[1624943] |
NPO27600 | Boesenbergia pandurata | Species | Zingiberaceae | Eukaryota | rhizomes | Pindaya Township, Shan State, Myanmar | 2004-NOV |
PMID[17896818] |
NPO20244 | Melicope semecarpifolia | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[18163582] |
NPO13135 | Campylotropis hirtella | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[19481938] |
NPO17376 | Bacillus amyloliquefaciens | Species | Bacillaceae | Bacteria | n.a. | n.a. | n.a. |
PMID[23265519] |
NPO17376 | Bacillus amyloliquefaciens | Species | Bacillaceae | Bacteria | n.a. | n.a. | n.a. |
PMID[24698790] |
NPO27600 | Boesenbergia pandurata | Species | Zingiberaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[27508308] |
NPO17376 | Bacillus amyloliquefaciens | Species | Bacillaceae | Bacteria | n.a. | n.a. | n.a. |
PMID[27934031] |
NPO27600 | Boesenbergia pandurata | Species | Zingiberaceae | Eukaryota | Rhizomes | n.a. | n.a. |
PMID[28099006] |
NPO12796 | Periploca sepium | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[28294615] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[30188125] |
NPO865 | Dendrobium loddigesii | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[31291099] |
NPO19745 | Esox lucius | Species | Esocidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[3349210] |
NPO28159 | Rubia akane | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[8176404] |
NPO19745 | Esox lucius | Species | Esocidae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO19745 | Esox lucius | Species | Esocidae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO12796 | Periploca sepium | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO20244 | Melicope semecarpifolia | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO21600 | Aconitum variegatum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO18591 | Senecio vulgaris | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO1373 | Pulsatilla chinensis | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO3642 | Crotalaria spartioides | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO7773 | Crinum moorei | Species | Amaryllidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO21175 | Senecio retrorsus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO13135 | Campylotropis hirtella | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO3392 | Agastache rugosus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO22500 | Stephania dielsiana | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO2379 | Senecio oryzetorum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO865 | Dendrobium loddigesii | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO6731 | Ononis spinosa | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO1373 | Pulsatilla chinensis | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO13135 | Campylotropis hirtella | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO865 | Dendrobium loddigesii | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO20244 | Melicope semecarpifolia | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22683 | Pteris bella | Species | Pteridaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO23156 | Maclura cochinchinensis | Species | Moraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22500 | Stephania dielsiana | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO27882 | Boswellia ovalifoliolata | Species | Burseraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO6731 | Ononis spinosa | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO12796 | Periploca sepium | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO27397 | Drymaria cordata | Species | Caryophyllaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO24496 | Gymnopetalum integrifolium | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO3642 | Crotalaria spartioides | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO3392 | Agastache rugosus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO2379 | Senecio oryzetorum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO18591 | Senecio vulgaris | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21600 | Aconitum variegatum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21175 | Senecio retrorsus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO7773 | Crinum moorei | Species | Amaryllidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO865 | Dendrobium loddigesii | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO1373 | Pulsatilla chinensis | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO6731 | Ononis spinosa | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO18591 | Senecio vulgaris | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO12796 | Periploca sepium | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO21600 | Aconitum variegatum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO2379 | Senecio oryzetorum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO12796 | Periploca sepium | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO28159 | Rubia akane | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO1373 | Pulsatilla chinensis | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO865 | Dendrobium loddigesii | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO27882 | Boswellia ovalifoliolata | Species | Burseraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27397 | Drymaria cordata | Species | Caryophyllaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12565 | Hypericum polyanthemum | Species | Hypericaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO18591 | Senecio vulgaris | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7822.1 | Eucalyptus globulus subsp. bicostata | Subspecies | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27145 | Euphorbia hylonoma | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27234 | Thalassiosira weissflogii | Species | Thalassiosiraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO26553 | Lemonia spectabilis | Species | Lemoniidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21175 | Senecio retrorsus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27702 | Matricaria sabulosa | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1373 | Pulsatilla chinensis | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28206 | Aniba santalodora | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23426 | Andromeda polifolia | Species | Ericaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19383 | Lactarius mitissimus | Species | Russulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3711 | Acalypha australis | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13135 | Campylotropis hirtella | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3642 | Crotalaria spartioides | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11190 | Veronica polita | Species | Plantaginaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24014 | Scapania bolanderi | Species | Scapaniaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19778 | Streptomyces flaveus | Species | Streptomycetaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11576 | Glycosmis macrophylla | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28426 | Etmopterus spinax | Species | Etmopteridae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO26321 | Salvia patens | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24576 | Genista lydia | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9354 | Lepechinia urbanii | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27854 | Sphaeria rousseliana | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27614 | Salix rosmarinifolia | Species | Salicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28083 | Salvia lavanduloides | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13008 | Methanobrevibacter arboriphilus | Species | Methanobacteriaceae | Archaea | n.a. | n.a. | n.a. | Database[UNPD] |
NPO26342 | Dialium excelsum | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28412 | Amorphophallus konjac | Species | Araceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6289 | Ceropegia dichotoma | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23156 | Maclura cochinchinensis | Species | Moraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27695 | Centaurea sonchifolia | Species | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10922 | Pentaclethra macrophylla | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20584 | Cheilanthes fragrans | Species | Pteridaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28289 | Nepytia freemani | Species | Geometridae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1815 | Breonia chinensis | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2030 | Mimosa pigra | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5456 | Juniperus drupacea | Species | Cupressaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12091 | Martensia denticulata | Species | Delesseriaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27600 | Boesenbergia pandurata | Species | Zingiberaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9704 | Sonneratia caseolaris | Species | Lythraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25499 | Campanula choziatowskyi | Species | Campanulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28044 | Erythrina hypaphorus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7773 | Crinum moorei | Species | Amaryllidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23300 | Trichilia heudelotii | Species | Meliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27986 | Lonchocarpus chiricanus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23384 | Rhodiola semenovii | Species | Crassulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16156 | Mucuna holtonii | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27338 | Senecio platyphylloides | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24184 | Argyrochosma pilifera | Species | Pteridaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5043 | Eria japonica | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28063 | Beilschmiedia madang | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16298 | Quercus marilandica | Species | Fagaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5970.1 | Petunia axillaris subsp. parodii | Subspecies | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22500 | Stephania dielsiana | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4164 | Salvia virgata | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21534 | Ostrya carpinifolia | Species | Betulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27613 | Helleborus macranthus | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO865 | Dendrobium loddigesii | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11849 | Cynoglossum macrostylum | Species | Boraginaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1257 | Distephanus angulifolius | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO29463 | Pogostemon cablin | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO526 | Salvia sessei | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28159 | Rubia akane | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10605 | Tristania conferta | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25835 | Parmotrema nilgherrense | Species | Parmeliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27816 | Pterocaulon serrulatum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6731 | Ononis spinosa | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21600 | Aconitum variegatum | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8934 | Gypsophila perfoliata | Species | Caryophyllaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10638 | Plectranthus myrianthus | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24139 | Calamus strictus | Species | Sparidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12796 | Periploca sepium | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2379 | Senecio oryzetorum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1184 | Colchicum filifolium | Species | Colchicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22691 | Mentha cardiaca | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3873 | Crotalaria candicans | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22683 | Pteris bella | Species | Pteridaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17337 | Centaurea scoparia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27642 | Podocarpus dacrydioides | Species | Podocarpaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28385 | Iris kashmiriana | Species | Tarachodidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9532 | Vernonia cistifolia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27637 | Heliotropium scabrum | Species | Heliotropiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17376 | Bacillus amyloliquefaciens | Species | Bacillaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27506 | Orgyia pseudotsugata | Species | Lymantriidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9319 | Pterocaulon virgatum | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12205 | Eucalyptus apodophylla | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25120 | Vincetoxicum forrestii | Species | Apocynaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27916 | Hardenbergia violacea | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO19745 | Esox lucius | Species | Esocidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28313 | Mentzelia decapetala | Species | Loasaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO20244 | Melicope semecarpifolia | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28003 | Astragalus circassicus | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27455 | Dysidea fragilis | Species | Dysideidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO26476 | Preussia terricola | Species | Sporormiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8961 | Bethencourtia palmensis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11843 | Stephania zippeliana | Species | Menispermaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16803 | Libanothamnus occultus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21720 | Talaromyces variabilis | Species | Trichocomaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27057 | Matsucoccus josephi | Species | Margarodidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24496 | Gymnopetalum integrifolium | Species | Cucurbitaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21344 | Fadogia agrestis | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
---|
☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT517 | Cell Line | Panel NCI-60 (60 carcinoma cell lines) | Homo sapiens | GI50 | = | 65000.0 | nM | PMID[527456] |
NPT91 | Cell Line | KB | Homo sapiens | ED50 | > | 25.0 | ug ml-1 | PMID[527459] |
NPT91 | Cell Line | KB | Homo sapiens | ED50 | = | 41.0 | ug ml-1 | PMID[527460] |
NPT1422 | Individual Protein | ATP-binding cassette sub-family G member 2 | Homo sapiens | IC50 | = | 390.0 | nM | PMID[527462] |
NPT1422 | Individual Protein | ATP-binding cassette sub-family G member 2 | Homo sapiens | IC50 | = | 900.0 | nM | PMID[527462] |
NPT1594 | Individual Protein | Multidrug resistance-associated protein 1 | Homo sapiens | IC50 | = | 50000.0 | nM | PMID[527462] |
NPT520 | Cell Line | 3T3-L1 | Mus musculus | Activity | = | 21.0 | % | PMID[527463] |
NPT520 | Cell Line | 3T3-L1 | Mus musculus | Activity | = | 11.2 | % | PMID[527463] |
NPT520 | Cell Line | 3T3-L1 | Mus musculus | Activity | = | 3.8 | % | PMID[527463] |
NPT367 | Cell Line | MDA-N | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT369 | Cell Line | ACHN | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT371 | Cell Line | UO-31 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT116 | Cell Line | HL-60 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT90 | Cell Line | DU-145 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT373 | Cell Line | SK-MEL-5 | Homo sapiens | GI50 | n.a. | 82035.15 | nM | PMID[527464] |
NPT375 | Cell Line | Malme-3M | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT111 | Cell Line | K562 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT376 | Cell Line | A498 | Homo sapiens | GI50 | n.a. | 16106.46 | nM | PMID[527464] |
NPT377 | Cell Line | OVCAR-3 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT112 | Cell Line | MOLT-4 | Homo sapiens | GI50 | n.a. | 10000.0 | nM | PMID[527464] |
NPT379 | Cell Line | HOP-62 | Homo sapiens | GI50 | n.a. | 58479.01 | nM | PMID[527464] |
NPT378 | Cell Line | NCI/ADR-RES | Homo sapiens | GI50 | n.a. | 62661.39 | nM | PMID[527464] |
NPT380 | Cell Line | U-251 | Homo sapiens | GI50 | n.a. | 15135.61 | nM | PMID[527464] |
NPT381 | Cell Line | OVCAR-8 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT382 | Cell Line | OVCAR-5 | Homo sapiens | GI50 | n.a. | 22961.49 | nM | PMID[527464] |
NPT383 | Cell Line | SNB-19 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT82 | Cell Line | MDA-MB-231 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT385 | Cell Line | SR | Homo sapiens | GI50 | n.a. | 10000.0 | nM | PMID[527464] |
NPT384 | Cell Line | TK-10 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT323 | Cell Line | SW-620 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT455 | Cell Line | NCI-H522 | Homo sapiens | GI50 | n.a. | 2786.12 | nM | PMID[527464] |
NPT387 | Cell Line | M14 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT388 | Cell Line | NCI-H322M | Homo sapiens | GI50 | n.a. | 41020.41 | nM | PMID[527464] |
NPT389 | Cell Line | RPMI-8226 | Homo sapiens | GI50 | n.a. | 87700.08 | nM | PMID[527464] |
NPT456 | Cell Line | OVCAR-4 | Homo sapiens | GI50 | n.a. | 61801.64 | nM | PMID[527464] |
NPT390 | Cell Line | LOX IMVI | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT391 | Cell Line | HCC 2998 | Homo sapiens | GI50 | n.a. | 94406.09 | nM | PMID[527464] |
NPT81 | Cell Line | A549 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT148 | Cell Line | HCT-15 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT393 | Cell Line | HCT-116 | Homo sapiens | GI50 | n.a. | 68706.84 | nM | PMID[527464] |
NPT395 | Cell Line | SF-268 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT394 | Cell Line | EKVX | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT83 | Cell Line | MCF7 | Homo sapiens | GI50 | n.a. | 45708.82 | nM | PMID[527464] |
NPT306 | Cell Line | PC-3 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT146 | Cell Line | SK-OV-3 | Homo sapiens | GI50 | n.a. | 5023.43 | nM | PMID[527464] |
NPT397 | Cell Line | NCI-H460 | Homo sapiens | GI50 | n.a. | 19952.62 | nM | PMID[527464] |
NPT396 | Cell Line | T47D | Homo sapiens | GI50 | n.a. | 31045.6 | nM | PMID[527464] |
NPT308 | Cell Line | CAKI-1 | Homo sapiens | GI50 | n.a. | 6165.95 | nM | PMID[527464] |
NPT398 | Cell Line | UACC-62 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT400 | Cell Line | MDA-MB-435 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT458 | Cell Line | IGROV-1 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT399 | Cell Line | SF-295 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT403 | Cell Line | UACC-257 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT404 | Cell Line | CCRF-CEM | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT139 | Cell Line | HT-29 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT170 | Cell Line | SK-MEL-28 | Homo sapiens | GI50 | n.a. | 18030.18 | nM | PMID[527464] |
NPT407 | Cell Line | COLO 205 | Homo sapiens | GI50 | n.a. | 100000.0 | nM | PMID[527464] |
NPT1628 | Individual Protein | Thrombin | Oryctolagus cuniculus | TT | = | 14.2 | s | PMID[527465] |
NPT1628 | Individual Protein | Thrombin | Oryctolagus cuniculus | PT | = | 5.4 | s | PMID[527465] |
NPT1628 | Individual Protein | Thrombin | Oryctolagus cuniculus | APTT | = | 42.4 | s | PMID[527465] |
NPT1628 | Individual Protein | Thrombin | Oryctolagus cuniculus | Activity | = | 8.4 | g/L | PMID[527465] |
NPT1460 | Cell Line | L929 | Mus musculus | IC50 | > | 100000.0 | nM | PMID[527466] |
NPT1422 | Individual Protein | ATP-binding cassette sub-family G member 2 | Homo sapiens | FC | = | 13.0 | n.a. | PMID[527466] |
NPT1422 | Individual Protein | ATP-binding cassette sub-family G member 2 | Homo sapiens | FC | = | 19.3 | n.a. | PMID[527466] |
NPT1594 | Individual Protein | Multidrug resistance-associated protein 1 | Homo sapiens | FC | = | 0.7 | n.a. | PMID[527466] |
NPT1380 | Individual Protein | Avian myoblastosis virus polyprotein II | Avian myeloblastosis virus | Inhibition | = | 9.2 | % | PMID[527467] |
NPT1422 | Individual Protein | ATP-binding cassette sub-family G member 2 | Homo sapiens | IC50 | = | 570.0 | nM | PMID[527469] |
NPT1422 | Individual Protein | ATP-binding cassette sub-family G member 2 | Homo sapiens | IC50 | = | 540.0 | nM | PMID[527469] |
NPT81 | Cell Line | A549 | Homo sapiens | IC50 | > | 50000.0 | nM | PMID[527471] |
NPT1668 | Cell Line | NCI-H157 | Homo sapiens | IC50 | > | 50000.0 | nM | PMID[527471] |
NPT1669 | Cell Line | NCI-H1792 | Homo sapiens | IC50 | > | 50000.0 | nM | PMID[527471] |
NPT455 | Cell Line | NCI-H522 | Homo sapiens | IC50 | > | 50000.0 | nM | PMID[527471] |
NPT379 | Cell Line | HOP-62 | Homo sapiens | IC50 | > | 50000.0 | nM | PMID[527471] |
NPT387 | Cell Line | M14 | Homo sapiens | IC50 | = | 380.0 | nM | PMID[527471] |
NPT165 | Cell Line | HeLa | Homo sapiens | IC50 | = | 46370.0 | nM | PMID[527471] |
NPT762 | Cell Line | A-431 | Homo sapiens | IC50 | = | 82250.0 | nM | PMID[527473] |
NPT1719 | Cell Line | 2008 | Homo sapiens | IC50 | > | 100000.0 | nM | PMID[527473] |
NPT762 | Cell Line | A-431 | Homo sapiens | Ratio IC50 | = | 1.4 | n.a. | PMID[527473] |
NPT71 | Cell Line | HEK293 | Homo sapiens | IC50 | = | 141870.0 | nM | PMID[527473] |
NPT71 | Cell Line | HEK293 | Homo sapiens | Ratio IC50 | = | 1.6 | n.a. | PMID[527473] |
NPT1083 | Cell Line | A-375 | Homo sapiens | IC50 | = | 69720.0 | nM | PMID[527473] |
NPT148 | Cell Line | HCT-15 | Homo sapiens | IC50 | = | 68110.0 | nM | PMID[527473] |
NPT83 | Cell Line | MCF7 | Homo sapiens | IC50 | > | 100000.0 | nM | PMID[527473] |
NPT762 | Cell Line | A-431 | Homo sapiens | IC50 | = | 57540.0 | nM | PMID[527473] |
NPT1048 | Organism | Poliovirus | Human enterovirus C | Max non-toxic dose | > | 50.0 | ug ml-1 | PMID[527455] |
NPT1048 | Organism | Poliovirus | Human enterovirus C | Reduction factor | = | 1.0 | n.a. | PMID[527455] |
NPT6 | Organism | Plasmodium falciparum | Plasmodium falciparum | IC50 | = | 73300.0 | nM | PMID[527457] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 1.43 | ug.mL-1 | PMID[527458] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 1.69 | ug.mL-1 | PMID[527458] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | deltaA | = | 0.23 | n.a. | PMID[527461] |
NPT2 | Others | Unspecified | IC50 | = | 12000.0 | nM | PMID[527462] | |
NPT668 | Individual Protein | P-glycoprotein 1 | Homo sapiens | IC50 | = | 16000.0 | nM | PMID[527462] |
NPT27 | Others | Unspecified | IC50 | > | 100000.0 | nM | PMID[527466] | |
NPT2 | Others | Unspecified | FC | = | 3.7 | n.a. | PMID[527466] | |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 28000.0 | nM | PMID[527470] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | > | 50000.0 | nM | PMID[527471] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 10460.0 | nM | PMID[527471] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 6530.0 | nM | PMID[527471] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | = | 390.0 | nM | PMID[527471] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | IC50 | > | 100000.0 | nM | PMID[527473] |
NPT23294 | CELL-LINE | C13 | n.a. | Ratio IC50 | = | 1.6 | n.a. | PMID[527473] |
NPT35 | Others | n.a. | Activity | = | 2.5 | % | PMID[527473] | |
NPT2 | Others | Unspecified | IC50 | > | 50000.0 | nM | PMID[527475] | |
NPT2 | Others | Unspecified | Ratio IC50 | = | 1.6 | n.a. | PMID[25906385] | |
NPT2 | Others | Unspecified | IC50 | > | 100000 | nM | PMID[25906385] |
☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.
Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC236769 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
0.9931 | High Similarity | NPC166753 |
0.9931 | High Similarity | NPC50728 |
0.9863 | High Similarity | NPC236223 |
0.9863 | High Similarity | NPC78326 |
0.9863 | High Similarity | NPC179126 |
0.9863 | High Similarity | NPC270620 |
0.9862 | High Similarity | NPC76376 |
0.9861 | High Similarity | NPC159103 |
0.9796 | High Similarity | NPC32557 |
0.9796 | High Similarity | NPC189960 |
0.9795 | High Similarity | NPC82325 |
0.9795 | High Similarity | NPC279989 |
0.9793 | High Similarity | NPC219330 |
0.9792 | High Similarity | NPC261548 |
0.9792 | High Similarity | NPC195202 |
0.973 | High Similarity | NPC178854 |
0.973 | High Similarity | NPC265511 |
0.9728 | High Similarity | NPC246204 |
0.9728 | High Similarity | NPC86485 |
0.9728 | High Similarity | NPC58382 |
0.9728 | High Similarity | NPC162351 |
0.9726 | High Similarity | NPC200740 |
0.9726 | High Similarity | NPC125062 |
0.9726 | High Similarity | NPC252933 |
0.9726 | High Similarity | NPC54394 |
0.9722 | High Similarity | NPC12200 |
0.9722 | High Similarity | NPC33265 |
0.9722 | High Similarity | NPC62536 |
0.9664 | High Similarity | NPC203891 |
0.9664 | High Similarity | NPC110070 |
0.9664 | High Similarity | NPC101830 |
0.966 | High Similarity | NPC123886 |
0.966 | High Similarity | NPC301123 |
0.966 | High Similarity | NPC55205 |
0.9658 | High Similarity | NPC188871 |
0.9658 | High Similarity | NPC149127 |
0.9658 | High Similarity | NPC286342 |
0.9653 | High Similarity | NPC310259 |
0.96 | High Similarity | NPC22472 |
0.96 | High Similarity | NPC176300 |
0.96 | High Similarity | NPC19687 |
0.96 | High Similarity | NPC4481 |
0.96 | High Similarity | NPC204854 |
0.96 | High Similarity | NPC288669 |
0.96 | High Similarity | NPC7846 |
0.96 | High Similarity | NPC18607 |
0.96 | High Similarity | NPC25495 |
0.96 | High Similarity | NPC115798 |
0.96 | High Similarity | NPC9609 |
0.96 | High Similarity | NPC18772 |
0.96 | High Similarity | NPC143828 |
0.96 | High Similarity | NPC191459 |
0.96 | High Similarity | NPC105242 |
0.96 | High Similarity | NPC300943 |
0.96 | High Similarity | NPC152166 |
0.96 | High Similarity | NPC130894 |
0.96 | High Similarity | NPC261004 |
0.96 | High Similarity | NPC253634 |
0.9597 | High Similarity | NPC43243 |
0.9597 | High Similarity | NPC55619 |
0.9597 | High Similarity | NPC200388 |
0.9597 | High Similarity | NPC49824 |
0.9597 | High Similarity | NPC292107 |
0.9597 | High Similarity | NPC245546 |
0.9597 | High Similarity | NPC100916 |
0.9597 | High Similarity | NPC266960 |
0.9592 | High Similarity | NPC28274 |
0.9592 | High Similarity | NPC50403 |
0.9592 | High Similarity | NPC226973 |
0.9592 | High Similarity | NPC308451 |
0.9592 | High Similarity | NPC133953 |
0.9592 | High Similarity | NPC208043 |
0.9592 | High Similarity | NPC260895 |
0.9589 | High Similarity | NPC287101 |
0.9589 | High Similarity | NPC270465 |
0.9589 | High Similarity | NPC87125 |
0.9589 | High Similarity | NPC223579 |
0.9589 | High Similarity | NPC328119 |
0.9589 | High Similarity | NPC183950 |
0.9589 | High Similarity | NPC52005 |
0.9589 | High Similarity | NPC48479 |
0.9589 | High Similarity | NPC137062 |
0.9589 | High Similarity | NPC177298 |
0.9586 | High Similarity | NPC299923 |
0.9533 | High Similarity | NPC75215 |
0.9533 | High Similarity | NPC472438 |
0.9533 | High Similarity | NPC224137 |
0.9533 | High Similarity | NPC7973 |
0.9533 | High Similarity | NPC227192 |
0.9533 | High Similarity | NPC29841 |
0.9533 | High Similarity | NPC287979 |
0.9533 | High Similarity | NPC189179 |
0.9533 | High Similarity | NPC471479 |
0.9533 | High Similarity | NPC305663 |
0.9533 | High Similarity | NPC78302 |
0.9533 | High Similarity | NPC93376 |
0.9533 | High Similarity | NPC471515 |
0.9533 | High Similarity | NPC176665 |
0.9533 | High Similarity | NPC235215 |
0.9533 | High Similarity | NPC163524 |
0.953 | High Similarity | NPC44079 |
0.953 | High Similarity | NPC56786 |
0.953 | High Similarity | NPC201451 |
0.953 | High Similarity | NPC26227 |
0.953 | High Similarity | NPC80534 |
0.953 | High Similarity | NPC133392 |
0.9527 | High Similarity | NPC60972 |
0.9527 | High Similarity | NPC134677 |
0.9527 | High Similarity | NPC39732 |
0.9524 | High Similarity | NPC306821 |
0.9521 | High Similarity | NPC120464 |
0.947 | High Similarity | NPC193842 |
0.9467 | High Similarity | NPC98661 |
0.9467 | High Similarity | NPC471500 |
0.9467 | High Similarity | NPC474520 |
0.9467 | High Similarity | NPC247017 |
0.9467 | High Similarity | NPC268161 |
0.9463 | High Similarity | NPC47781 |
0.9463 | High Similarity | NPC22519 |
0.9463 | High Similarity | NPC176775 |
0.9463 | High Similarity | NPC160951 |
0.9463 | High Similarity | NPC274327 |
0.9463 | High Similarity | NPC255350 |
0.9463 | High Similarity | NPC145379 |
0.9463 | High Similarity | NPC69394 |
0.9463 | High Similarity | NPC183878 |
0.9463 | High Similarity | NPC231018 |
0.9456 | High Similarity | NPC69752 |
0.9452 | High Similarity | NPC108406 |
0.9444 | High Similarity | NPC70853 |
0.9444 | High Similarity | NPC9966 |
0.9408 | High Similarity | NPC246478 |
0.9408 | High Similarity | NPC269906 |
0.9404 | High Similarity | NPC174908 |
0.9404 | High Similarity | NPC67876 |
0.94 | High Similarity | NPC146165 |
0.94 | High Similarity | NPC196439 |
0.94 | High Similarity | NPC138360 |
0.94 | High Similarity | NPC2476 |
0.94 | High Similarity | NPC50715 |
0.94 | High Similarity | NPC4455 |
0.94 | High Similarity | NPC213622 |
0.94 | High Similarity | NPC280339 |
0.94 | High Similarity | NPC167815 |
0.94 | High Similarity | NPC214138 |
0.94 | High Similarity | NPC201136 |
0.94 | High Similarity | NPC163780 |
0.94 | High Similarity | NPC20830 |
0.94 | High Similarity | NPC128863 |
0.94 | High Similarity | NPC183597 |
0.94 | High Similarity | NPC227325 |
0.94 | High Similarity | NPC92659 |
0.94 | High Similarity | NPC256612 |
0.9396 | High Similarity | NPC471982 |
0.9396 | High Similarity | NPC275722 |
0.9396 | High Similarity | NPC239128 |
0.9396 | High Similarity | NPC25270 |
0.9396 | High Similarity | NPC71334 |
0.9396 | High Similarity | NPC37684 |
0.9396 | High Similarity | NPC304954 |
0.9396 | High Similarity | NPC100887 |
0.9396 | High Similarity | NPC301323 |
0.9396 | High Similarity | NPC187498 |
0.9396 | High Similarity | NPC156222 |
0.9396 | High Similarity | NPC63187 |
0.9396 | High Similarity | NPC131624 |
0.9396 | High Similarity | NPC198826 |
0.9396 | High Similarity | NPC188203 |
0.9396 | High Similarity | NPC293183 |
0.9396 | High Similarity | NPC241498 |
0.9396 | High Similarity | NPC162313 |
0.9396 | High Similarity | NPC120163 |
0.9396 | High Similarity | NPC275836 |
0.9396 | High Similarity | NPC256283 |
0.9396 | High Similarity | NPC222830 |
0.9396 | High Similarity | NPC212678 |
0.9396 | High Similarity | NPC57030 |
0.9396 | High Similarity | NPC157784 |
0.9396 | High Similarity | NPC83508 |
0.9392 | High Similarity | NPC259058 |
0.9392 | High Similarity | NPC201547 |
0.9392 | High Similarity | NPC338131 |
0.9384 | High Similarity | NPC20791 |
0.9384 | High Similarity | NPC179271 |
0.9379 | High Similarity | NPC113089 |
0.9375 | High Similarity | NPC29536 |
0.9375 | High Similarity | NPC90582 |
0.9375 | High Similarity | NPC262094 |
0.9342 | High Similarity | NPC280680 |
0.9342 | High Similarity | NPC152904 |
0.9342 | High Similarity | NPC195832 |
0.9338 | High Similarity | NPC326037 |
0.9338 | High Similarity | NPC320825 |
0.9338 | High Similarity | NPC13858 |
0.9333 | High Similarity | NPC250822 |
0.9333 | High Similarity | NPC280937 |
0.9333 | High Similarity | NPC276409 |
0.9333 | High Similarity | NPC75279 |
0.9333 | High Similarity | NPC472915 |
0.9333 | High Similarity | NPC18727 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC236769 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
0.9463 | High Similarity | NPD2801 | Approved |
0.94 | High Similarity | NPD3817 | Phase 2 |
0.9384 | High Similarity | NPD1512 | Approved |
0.9338 | High Similarity | NPD3882 | Suspended |
0.9267 | High Similarity | NPD1934 | Approved |
0.9247 | High Similarity | NPD1511 | Approved |
0.9184 | High Similarity | NPD4378 | Clinical (unspecified phase) |
0.9079 | High Similarity | NPD2393 | Clinical (unspecified phase) |
0.9045 | High Similarity | NPD6167 | Clinical (unspecified phase) |
0.9045 | High Similarity | NPD6166 | Phase 2 |
0.9045 | High Similarity | NPD6168 | Clinical (unspecified phase) |
0.8889 | High Similarity | NPD7808 | Phase 3 |
0.8882 | High Similarity | NPD6797 | Phase 2 |
0.8827 | High Similarity | NPD7251 | Discontinued |
0.8773 | High Similarity | NPD4338 | Clinical (unspecified phase) |
0.8758 | High Similarity | NPD7054 | Approved |
0.8733 | High Similarity | NPD6799 | Approved |
0.8704 | High Similarity | NPD7472 | Approved |
0.8696 | High Similarity | NPD3818 | Discontinued |
0.8662 | High Similarity | NPD7075 | Discontinued |
0.859 | High Similarity | NPD7096 | Clinical (unspecified phase) |
0.8589 | High Similarity | NPD7074 | Phase 3 |
0.8581 | High Similarity | NPD1550 | Clinical (unspecified phase) |
0.8581 | High Similarity | NPD1552 | Clinical (unspecified phase) |
0.8571 | High Similarity | NPD1510 | Phase 2 |
0.8526 | High Similarity | NPD6801 | Discontinued |
0.8523 | High Similarity | NPD1549 | Phase 2 |
0.8516 | High Similarity | NPD4380 | Phase 2 |
0.8514 | High Similarity | NPD2796 | Approved |
0.8447 | Intermediate Similarity | NPD6232 | Discontinued |
0.8438 | Intermediate Similarity | NPD5494 | Approved |
0.8431 | Intermediate Similarity | NPD7410 | Clinical (unspecified phase) |
0.8428 | Intermediate Similarity | NPD4381 | Clinical (unspecified phase) |
0.8425 | Intermediate Similarity | NPD1240 | Approved |
0.8418 | Intermediate Similarity | NPD5402 | Approved |
0.8415 | Intermediate Similarity | NPD7804 | Clinical (unspecified phase) |
0.8405 | Intermediate Similarity | NPD7473 | Discontinued |
0.8397 | Intermediate Similarity | NPD6599 | Discontinued |
0.8385 | Intermediate Similarity | NPD1247 | Approved |
0.8375 | Intermediate Similarity | NPD919 | Approved |
0.8365 | Intermediate Similarity | NPD4868 | Clinical (unspecified phase) |
0.8323 | Intermediate Similarity | NPD5403 | Approved |
0.8311 | Intermediate Similarity | NPD1607 | Approved |
0.8282 | Intermediate Similarity | NPD3926 | Phase 2 |
0.8278 | Intermediate Similarity | NPD970 | Clinical (unspecified phase) |
0.8239 | Intermediate Similarity | NPD7819 | Suspended |
0.8194 | Intermediate Similarity | NPD5401 | Approved |
0.8187 | Intermediate Similarity | NPD8443 | Clinical (unspecified phase) |
0.8113 | Intermediate Similarity | NPD7411 | Suspended |
0.8095 | Intermediate Similarity | NPD7993 | Clinical (unspecified phase) |
0.8084 | Intermediate Similarity | NPD5844 | Phase 1 |
0.8054 | Intermediate Similarity | NPD943 | Approved |
0.8052 | Intermediate Similarity | NPD3750 | Approved |
0.8049 | Intermediate Similarity | NPD6959 | Discontinued |
0.8012 | Intermediate Similarity | NPD1465 | Phase 2 |
0.8 | Intermediate Similarity | NPD447 | Suspended |
0.7975 | Intermediate Similarity | NPD6980 | Clinical (unspecified phase) |
0.7919 | Intermediate Similarity | NPD6859 | Clinical (unspecified phase) |
0.7908 | Intermediate Similarity | NPD2935 | Discontinued |
0.7908 | Intermediate Similarity | NPD1551 | Phase 2 |
0.7905 | Intermediate Similarity | NPD1529 | Clinical (unspecified phase) |
0.7871 | Intermediate Similarity | NPD2800 | Approved |
0.7844 | Intermediate Similarity | NPD7184 | Clinical (unspecified phase) |
0.7843 | Intermediate Similarity | NPD651 | Clinical (unspecified phase) |
0.7838 | Intermediate Similarity | NPD1530 | Clinical (unspecified phase) |
0.7836 | Intermediate Similarity | NPD6559 | Discontinued |
0.7815 | Intermediate Similarity | NPD1613 | Approved |
0.7815 | Intermediate Similarity | NPD1612 | Clinical (unspecified phase) |
0.7805 | Intermediate Similarity | NPD7768 | Phase 2 |
0.7798 | Intermediate Similarity | NPD7852 | Clinical (unspecified phase) |
0.7785 | Intermediate Similarity | NPD6143 | Clinical (unspecified phase) |
0.7763 | Intermediate Similarity | NPD1933 | Approved |
0.7763 | Intermediate Similarity | NPD230 | Phase 1 |
0.7758 | Intermediate Similarity | NPD3749 | Approved |
0.7756 | Intermediate Similarity | NPD7421 | Clinical (unspecified phase) |
0.7736 | Intermediate Similarity | NPD2533 | Approved |
0.7736 | Intermediate Similarity | NPD2532 | Approved |
0.7736 | Intermediate Similarity | NPD2534 | Approved |
0.7733 | Intermediate Similarity | NPD3027 | Phase 3 |
0.7727 | Intermediate Similarity | NPD3748 | Approved |
0.7707 | Intermediate Similarity | NPD1878 | Clinical (unspecified phase) |
0.7706 | Intermediate Similarity | NPD3751 | Discontinued |
0.7679 | Intermediate Similarity | NPD3787 | Discontinued |
0.7677 | Intermediate Similarity | NPD6099 | Approved |
0.7677 | Intermediate Similarity | NPD6100 | Approved |
0.7658 | Intermediate Similarity | NPD6190 | Approved |
0.7643 | Intermediate Similarity | NPD1243 | Approved |
0.764 | Intermediate Similarity | NPD920 | Approved |
0.7628 | Intermediate Similarity | NPD2344 | Approved |
0.7619 | Intermediate Similarity | NPD7199 | Phase 2 |
0.7597 | Intermediate Similarity | NPD6651 | Approved |
0.7595 | Intermediate Similarity | NPD4628 | Phase 3 |
0.7586 | Intermediate Similarity | NPD4419 | Clinical (unspecified phase) |
0.7584 | Intermediate Similarity | NPD1203 | Approved |
0.7568 | Intermediate Similarity | NPD4379 | Clinical (unspecified phase) |
0.7566 | Intermediate Similarity | NPD2313 | Discontinued |
0.7546 | Intermediate Similarity | NPD3226 | Approved |
0.7541 | Intermediate Similarity | NPD7501 | Clinical (unspecified phase) |
0.7517 | Intermediate Similarity | NPD1548 | Phase 1 |
0.7516 | Intermediate Similarity | NPD642 | Clinical (unspecified phase) |
0.75 | Intermediate Similarity | NPD643 | Clinical (unspecified phase) |
0.75 | Intermediate Similarity | NPD2799 | Discontinued |
0.75 | Intermediate Similarity | NPD1509 | Clinical (unspecified phase) |
0.7485 | Intermediate Similarity | NPD2403 | Approved |
0.7485 | Intermediate Similarity | NPD1653 | Approved |
0.7483 | Intermediate Similarity | NPD9494 | Approved |
0.7473 | Intermediate Similarity | NPD8090 | Clinical (unspecified phase) |
0.7471 | Intermediate Similarity | NPD5953 | Discontinued |
0.7457 | Intermediate Similarity | NPD7286 | Phase 2 |
0.7453 | Intermediate Similarity | NPD7390 | Discontinued |
0.7451 | Intermediate Similarity | NPD3268 | Approved |
0.7451 | Intermediate Similarity | NPD6798 | Discontinued |
0.7444 | Intermediate Similarity | NPD7879 | Clinical (unspecified phase) |
0.7438 | Intermediate Similarity | NPD2309 | Approved |
0.7434 | Intermediate Similarity | NPD6832 | Phase 2 |
0.7434 | Intermediate Similarity | NPD4908 | Phase 1 |
0.7432 | Intermediate Similarity | NPD422 | Phase 1 |
0.7419 | Intermediate Similarity | NPD1899 | Clinical (unspecified phase) |
0.7417 | Intermediate Similarity | NPD2798 | Approved |
0.741 | Intermediate Similarity | NPD37 | Approved |
0.7405 | Intermediate Similarity | NPD2346 | Discontinued |
0.7403 | Intermediate Similarity | NPD6233 | Phase 2 |
0.7396 | Intermediate Similarity | NPD6234 | Discontinued |
0.7389 | Intermediate Similarity | NPD7033 | Discontinued |
0.7384 | Intermediate Similarity | NPD7784 | Clinical (unspecified phase) |
0.7383 | Intermediate Similarity | NPD9717 | Approved |
0.7381 | Intermediate Similarity | NPD4966 | Approved |
0.7381 | Intermediate Similarity | NPD4965 | Approved |
0.7381 | Intermediate Similarity | NPD4967 | Phase 2 |
0.7375 | Intermediate Similarity | NPD6398 | Clinical (unspecified phase) |
0.7368 | Intermediate Similarity | NPD3018 | Phase 2 |
0.736 | Intermediate Similarity | NPD8055 | Clinical (unspecified phase) |
0.7351 | Intermediate Similarity | NPD2797 | Approved |
0.7338 | Intermediate Similarity | NPD4907 | Clinical (unspecified phase) |
0.7333 | Intermediate Similarity | NPD8397 | Clinical (unspecified phase) |
0.7329 | Intermediate Similarity | NPD5536 | Phase 2 |
0.7326 | Intermediate Similarity | NPD5242 | Approved |
0.7315 | Intermediate Similarity | NPD1547 | Clinical (unspecified phase) |
0.7315 | Intermediate Similarity | NPD1610 | Phase 2 |
0.7312 | Intermediate Similarity | NPD2654 | Approved |
0.7308 | Intermediate Similarity | NPD6355 | Discontinued |
0.7285 | Intermediate Similarity | NPD3225 | Approved |
0.7278 | Intermediate Similarity | NPD4308 | Phase 3 |
0.7268 | Intermediate Similarity | NPD4360 | Phase 2 |
0.7268 | Intermediate Similarity | NPD4363 | Phase 3 |
0.7267 | Intermediate Similarity | NPD1608 | Approved |
0.7246 | Intermediate Similarity | NPD6385 | Approved |
0.7246 | Intermediate Similarity | NPD6386 | Approved |
0.7244 | Intermediate Similarity | NPD4060 | Phase 1 |
0.7239 | Intermediate Similarity | NPD4357 | Discontinued |
0.7232 | Intermediate Similarity | NPD7685 | Pre-registration |
0.7226 | Intermediate Similarity | NPD411 | Approved |
0.7222 | Intermediate Similarity | NPD8434 | Phase 2 |
0.7222 | Intermediate Similarity | NPD2354 | Approved |
0.7219 | Intermediate Similarity | NPD2983 | Phase 2 |
0.7219 | Intermediate Similarity | NPD2982 | Phase 2 |
0.7219 | Intermediate Similarity | NPD5353 | Approved |
0.7202 | Intermediate Similarity | NPD6844 | Discontinued |
0.72 | Intermediate Similarity | NPD2163 | Approved |
0.7195 | Intermediate Similarity | NPD7004 | Clinical (unspecified phase) |
0.7195 | Intermediate Similarity | NPD3688 | Clinical (unspecified phase) |
0.7195 | Intermediate Similarity | NPD3146 | Approved |
0.7188 | Intermediate Similarity | NPD1471 | Phase 3 |
0.7168 | Intermediate Similarity | NPD5710 | Approved |
0.7168 | Intermediate Similarity | NPD5711 | Approved |
0.7161 | Intermediate Similarity | NPD7095 | Approved |
0.7161 | Intermediate Similarity | NPD4625 | Phase 3 |
0.7152 | Intermediate Similarity | NPD9269 | Phase 2 |
0.7152 | Intermediate Similarity | NPD2981 | Phase 2 |
0.7135 | Intermediate Similarity | NPD4361 | Phase 2 |
0.7135 | Intermediate Similarity | NPD4362 | Clinical (unspecified phase) |
0.7124 | Intermediate Similarity | NPD3266 | Approved |
0.7124 | Intermediate Similarity | NPD3267 | Approved |
0.7118 | Intermediate Similarity | NPD4288 | Approved |
0.7117 | Intermediate Similarity | NPD3887 | Approved |
0.7114 | Intermediate Similarity | NPD9268 | Approved |
0.7105 | Intermediate Similarity | NPD4749 | Approved |
0.7102 | Intermediate Similarity | NPD7228 | Approved |
0.7099 | Intermediate Similarity | NPD1652 | Phase 2 |
0.7089 | Intermediate Similarity | NPD4340 | Discontinued |
0.7086 | Intermediate Similarity | NPD1201 | Approved |
0.7081 | Intermediate Similarity | NPD2355 | Clinical (unspecified phase) |
0.7081 | Intermediate Similarity | NPD2353 | Approved |
0.7074 | Intermediate Similarity | NPD6782 | Approved |
0.7074 | Intermediate Similarity | NPD6779 | Approved |
0.7074 | Intermediate Similarity | NPD6777 | Approved |
0.7074 | Intermediate Similarity | NPD6778 | Approved |
0.7074 | Intermediate Similarity | NPD6781 | Approved |
0.7074 | Intermediate Similarity | NPD6780 | Approved |
0.7074 | Intermediate Similarity | NPD6776 | Approved |
0.707 | Intermediate Similarity | NPD4062 | Phase 3 |
0.7069 | Intermediate Similarity | NPD7229 | Phase 3 |
0.7067 | Intermediate Similarity | NPD17 | Approved |
0.7056 | Intermediate Similarity | NPD8313 | Approved |
0.7056 | Intermediate Similarity | NPD8312 | Approved |
0.7053 | Intermediate Similarity | NPD7435 | Discontinued |
0.7048 | Intermediate Similarity | NPD5049 | Phase 3 |
0.7047 | Intermediate Similarity | NPD9545 | Approved |
0.7041 | Intermediate Similarity | NPD7615 | Clinical (unspecified phase) |
0.7039 | Intermediate Similarity | NPD7038 | Approved |
Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.