Structure

Physi-Chem Properties

Molecular Weight:  300.06
Volume:  291.273
LogP:  3.154
LogD:  2.444
LogS:  -3.631
# Rotatable Bonds:  2
TPSA:  100.13
# H-Bond Aceptor:  6
# H-Bond Donor:  3
# Rings:  3
# Heavy Atoms:  6

MedChem Properties

QED Drug-Likeness Score:  0.672
Synthetic Accessibility Score:  2.389
Fsp3:  0.062
Lipinski Rule-of-5:  Accepted
Pfizer Rule:  Accepted
GSK Rule:  Accepted
BMS Rule:  0
Golden Triangle Rule:  Accepted
Chelating Alert:  1
PAINS Alert:  0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:  -4.882
MDCK Permeability:  1.230998805112904e-05
Pgp-inhibitor:  0.011
Pgp-substrate:  0.928
Human Intestinal Absorption (HIA):  0.017
20% Bioavailability (F20%):  0.463
30% Bioavailability (F30%):  0.985

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):  0.004
Plasma Protein Binding (PPB):  96.96226501464844%
Volume Distribution (VD):  0.52
Pgp-substrate:  7.814716339111328%

ADMET: Metabolism

CYP1A2-inhibitor:  0.971
CYP1A2-substrate:  0.824
CYP2C19-inhibitor:  0.391
CYP2C19-substrate:  0.059
CYP2C9-inhibitor:  0.686
CYP2C9-substrate:  0.894
CYP2D6-inhibitor:  0.676
CYP2D6-substrate:  0.495
CYP3A4-inhibitor:  0.524
CYP3A4-substrate:  0.156

ADMET: Excretion

Clearance (CL):  4.798
Half-life (T1/2):  0.857

ADMET: Toxicity

hERG Blockers:  0.099
Human Hepatotoxicity (H-HT):  0.057
Drug-inuced Liver Injury (DILI):  0.913
AMES Toxicity:  0.395
Rat Oral Acute Toxicity:  0.073
Maximum Recommended Daily Dose:  0.139
Skin Sensitization:  0.906
Carcinogencity:  0.225
Eye Corrosion:  0.004
Eye Irritation:  0.924
Respiratory Toxicity:  0.241

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs  

  Natural Product: NPC241498

Natural Product ID:  NPC241498
Common Name*:   Hispidulin
IUPAC Name:   5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one
Synonyms:   NSC-122415; TCMDC-123942
Standard InCHIKey:  IHFBPDAQLQOCBX-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
SMILES:  COc1c(cc2c(c(=O)cc(c3ccc(cc3)O)o2)c1O)O
Synthetic Gene Cluster:   n.a.
ChEMBL Identifier:   CHEMBL293776
PubChem CID:   5281628
Chemical Classification**:  
  • CHEMONTID:0000000 [Organic compounds]
    • [CHEMONTID:0000261] Phenylpropanoids and polyketides
      • [CHEMONTID:0000334] Flavonoids
        • [CHEMONTID:0002585] O-methylated flavonoids
          • [CHEMONTID:0002591] 6-O-methylated flavonoids

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO14367 Hypericum hirsutum Species Hypericaceae Eukaryota n.a. n.a. n.a. DOI[10.1007/BF00597593]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. DOI[10.1007/s11746-997-0093-1]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. Wrocław, Poland 2004–2005 DOI[10.1016/J.FOODCHEM.2006.08.014]
NPO28276 Artemisia argyi Species Asteraceae Eukaryota n.a. n.a. n.a. DOI[10.1016/j.jep.2005.01.054]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. retail stores, supermarkets and market stalls in Forssa and in the Helsinki area 2003–2005 DOI[10.1016/j.jfca.2006.05.007]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. DOI[10.1021/jf950732o]
NPO17829 Ibervillea sonorae Species Cucurbitaceae Eukaryota n.a. n.a. n.a. DOI[10.1055/s-2007-967117]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[10096857]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[10775096]
NPO6987 Tolypothrix byssoidea Species Tolypothrichaceae Bacteria n.a. n.a. n.a. PMID[11429991]
NPO16484 Muraltia heisteria Species Polygalaceae Eukaryota n.a. n.a. n.a. PMID[11858755]
NPO17270 Warionia saharae Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[11975493]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota Leaves n.a. n.a. PMID[12088434]
NPO6596 Vaccinium ashei Species Ericaceae Eukaryota n.a. fruit n.a. PMID[12372879]
NPO15289 Scoparia dulcis Species Plantaginaceae Eukaryota n.a. n.a. n.a. PMID[12880314]
NPO15289 Scoparia dulcis Species Plantaginaceae Eukaryota n.a. whole plant n.a. PMID[1294695]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. n.a. PMID[15019787]
NPO15289 Scoparia dulcis Species Plantaginaceae Eukaryota n.a. n.a. n.a. PMID[15104516]
NPO20756 Aspergillus unilateralis Species Aspergillaceae Eukaryota n.a. n.a. n.a. PMID[15602607]
NPO11318 Eriodictyon californicum Species Namaceae Eukaryota n.a. n.a. n.a. PMID[1593282]
NPO17691 Santalum album Species Santalaceae Eukaryota n.a. n.a. n.a. PMID[15974602]
NPO22460 Vernonia pachyclada Species Asteraceae Eukaryota n.a. Madagascar rainforest n.a. PMID[16180816]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. root n.a. PMID[1622242]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. root n.a. PMID[16441081]
NPO15289 Scoparia dulcis Species Plantaginaceae Eukaryota leaves and twigs Taiwan n.a. PMID[1659612]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[16659156]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[16668466]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[16675659]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. whole plant n.a. PMID[16755060]
NPO23838 Kitasatospora kifunensis Species Streptomycetaceae Bacteria n.a. n.a. n.a. PMID[17191679]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. aerial part n.a. PMID[17666848]
NPO22874 Bombyx mori Species Bombycidae Eukaryota n.a. n.a. n.a. PMID[18071251]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. aerial part n.a. PMID[18239311]
NPO22874 Bombyx mori Species Bombycidae Eukaryota n.a. faeces n.a. PMID[18323202]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[18460139]
NPO2865 Abrus precatorius Species Fabaceae Eukaryota aerial parts n.a. n.a. PMID[19299148]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[19388660]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[19785430]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[19962306]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[20078074]
NPO25456 Cortinarius infractus Species Cortinariaceae Eukaryota Toadstool n.a. n.a. PMID[20176490]
NPO25579 Alstonia pneumatophora Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[20576577]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[20963508]
NPO17462 Pouteria sapota Species Sapotaceae Eukaryota n.a. ripe fruit n.a. PMID[21214217]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[21524573]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[21707257]
NPO20096 Cirsium japonicum Species Asteraceae Eukaryota n.a. whole plant n.a. PMID[21899269]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. n.a. PMID[22029392]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[22074222]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. root n.a. PMID[22074222]
NPO2865 Abrus precatorius Species Fabaceae Eukaryota n.a. leaf n.a. PMID[22210168]
NPO2865 Abrus precatorius Species Fabaceae Eukaryota n.a. stem n.a. PMID[22210168]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[22537213]
NPO2286 Fischerella muscicola Species Hapalosiphonaceae Bacteria n.a. n.a. n.a. PMID[22863526]
NPO8881 Centipeda minima Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[23189738]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[23507152]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. n.a. PMID[23517479]
NPO17620 Rhodopirellula baltica Species Planctomycetaceae Bacteria n.a. n.a. n.a. PMID[23826385]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. root n.a. PMID[23867078]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. rhizome n.a. PMID[23867078]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[24479468]
NPO7635 Glycine max Species Fabaceae Eukaryota Seeds Tekirdag, Turkey PMID[24499198]
NPO15289 Scoparia dulcis Species Plantaginaceae Eukaryota aerial parts Nanning, Guangxi Zhuang Autonomous Region, Peoples Republic of China 2012-OCT PMID[24955889]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota roots n.a. n.a. PMID[24957203]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[25053043]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[25070365]
NPO10051 Phyla nodiflora Species Verbenaceae Eukaryota n.a. aerial part n.a. PMID[25140335]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. seed n.a. PMID[25369450]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[25369450]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[25445757]
NPO12737.1 Torreya fargesii var. yunnanensis Varieties Taxaceae Eukaryota n.a. n.a. n.a. PMID[25495612]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota whole plants Nanning District, Guangxi Province, China 2012-Sep PMID[25647077]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[25744461]
NPO17462 Pouteria sapota Species Sapotaceae Eukaryota n.a. n.a. n.a. PMID[26057604]
NPO18671 Saussurea involucrata Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[26214875]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota aerial parts Seoul, Korea n.a. PMID[26331882]
NPO8918 Plantago depressa Species Plantaginaceae Eukaryota n.a. n.a. n.a. PMID[26562611]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[26841168]
NPO2865 Abrus precatorius Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[2691636]
NPO2865 Abrus precatorius Species Fabaceae Eukaryota Leaves n.a. n.a. PMID[2691636]
NPO17346 Salvia plebeia Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[27933899]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. PMID[28362501]
NPO17346 Salvia plebeia Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[28960981]
NPO759 Asphodelus tenuifolius Species Asphodelaceae Eukaryota n.a. n.a. n.a. PMID[30063349]
NPO40718 Indian beech tree Strain n.a. n.a. n.a. n.a. n.a. PMID[30108931]
NPO15473 Ocotea heterochroma Species Lauraceae Eukaryota leaves n.a. n.a. PMID[30188730]
NPO28276 Artemisia argyi Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[31181920]
NPO28276 Artemisia argyi Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[31418264]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[32196343]
NPO22657 Centaurea sp. Species n.a. n.a. n.a. n.a. n.a. PMID[6512542]
NPO7635 Glycine max Species Fabaceae Eukaryota Seed n.a. n.a. Database[FooDB]
NPO42012 Rosmarinus officinalis Species Lamiaceae Eukaryota Leaf n.a. n.a. Database[FooDB]
NPO794 Lippia graveolens Species Verbenaceae Eukaryota Shoot n.a. n.a. Database[FooDB]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota Leaf n.a. n.a. Database[FooDB]
NPO41199 Origanum x majoricum Strain Lamiaceae Eukaryota n.a. n.a. Database[FooDB]
NPO42012 Rosmarinus officinalis Species Lamiaceae Eukaryota Shoot n.a. n.a. Database[FooDB]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota Leaf n.a. n.a. Database[FooDB]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. Database[FooDB]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota Shoot n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Leaf n.a. n.a. Database[FooDB]
NPO1786 Pyrus pyrifolia Species Rosaceae Eukaryota n.a. n.a. Database[FooDB]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota Shoot n.a. n.a. Database[FooDB]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota Leaf Essent. Oil n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Oil n.a. n.a. Database[FooDB]
NPO17462 Pouteria sapota Species Sapotaceae Eukaryota n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Sprout Seedling n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Pericarp n.a. n.a. Database[FooDB]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota Stem n.a. n.a. Database[FooDB]
NPO42012 Rosmarinus officinalis Species Lamiaceae Eukaryota Plant n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Stem n.a. n.a. Database[FooDB]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota Plant n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Testa n.a. n.a. Database[FooDB]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota Plant n.a. n.a. Database[FooDB]
NPO42012 Rosmarinus officinalis Species Lamiaceae Eukaryota Tissue Culture n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Plant n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. Database[FooDB]
NPO794 Lippia graveolens Species Verbenaceae Eukaryota n.a. n.a. Database[FooDB]
NPO794 Lippia graveolens Species Verbenaceae Eukaryota Root n.a. n.a. Database[FooDB]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Cotyledon n.a. n.a. Database[FooDB]
NPO42012 Rosmarinus officinalis Species Lamiaceae Eukaryota n.a. n.a. Database[FooDB]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota Root n.a. n.a. Database[FooDB]
NPO42012 Rosmarinus officinalis Species Lamiaceae Eukaryota n.a. n.a. Database[FooDB]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota Essential Oil n.a. n.a. Database[FooDB]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Root n.a. n.a. Database[FooDB]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Fruit n.a. n.a. Database[FooDB]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota n.a. n.a. Database[FooDB]
NPO20640 Aloysia triphylla Species Verbenaceae Eukaryota n.a. n.a. Database[FooDB]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota Seed n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. Database[FooDB]
NPO7635 Glycine max Species Fabaceae Eukaryota Hypocotyl n.a. n.a. Database[FooDB]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota Seed n.a. n.a. Database[FooDB]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. Database[FooDB]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota Latex Exudate n.a. n.a. Database[FooDB]
NPO28508 Flourensia cernua Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO22245 Digitalis lanata Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO21824 Lycopus lucidus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO2865 Abrus precatorius Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO13969 Clerodendron indicum n.a. n.a. n.a. n.a. n.a. n.a. Database[HerDing]
NPO17464 Uncaria sessilifructus Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO18671 Saussurea involucrata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO20096 Cirsium japonicum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO21263 Fructus kochiae n.a. n.a. n.a. n.a. n.a. n.a. Database[HerDing]
NPO9295 Clerodendron fragrans n.a. n.a. n.a. n.a. n.a. n.a. Database[HerDing]
NPO7176 Citrus sudachii Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO8881 Centipeda minima Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17949 Gentiana thunbergii Species Gentianaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO15289 Scoparia dulcis Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO27772 Flos inulae Species Lycaenidae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO28276 Artemisia argyi Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO228 Physostigma venenosum Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO8918 Plantago depressa Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO26233 Helenium autumnale Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17346 Salvia plebeia Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7527 Isodon leucophyllus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO29384.1 Glycyrrhiza glabra var. typica Varieties Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17691 Santalum album Species Santalaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17270 Warionia saharae Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO1786 Pyrus pyrifolia Species Rosaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5788 Millingtonia hortensis Species Bignoniaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO22769 Iva frutescens Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO11874 Ambrosia hispida Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5095 Digitalis ferruginea Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23653 Nepeta hindostana Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17106 Phyllanthus discoides Species Leiothrichidae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO22874 Bombyx mori Species Bombycidae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO18920 Hexalobus crispiflorus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17827 Scutellaria przewalskii Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO11697 Cirsium setosum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO19162 Tsuga heterophylla Species Pinaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. Database[MetaboLights]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. seed n.a. Database[MetaboLights]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota n.a. n.a. Database[Phenol-Explorer]
NPO41199 Origanum x majoricum Strain Lamiaceae Eukaryota n.a. n.a. Database[Phenol-Explorer]
NPO42012 Rosmarinus officinalis Species Lamiaceae Eukaryota n.a. n.a. Database[Phenol-Explorer]
NPO7635 Glycine max Species Fabaceae Eukaryota Seeds n.a. Database[Phenol-Explorer]
NPO13969 Clerodendron indicum n.a. n.a. n.a. n.a. n.a. n.a. Database[TCMID]
NPO8918 Plantago depressa Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO18671 Saussurea involucrata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19162 Tsuga heterophylla Species Pinaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23653 Nepeta hindostana Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO18920 Hexalobus crispiflorus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26233 Helenium autumnale Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9295 Clerodendron fragrans n.a. n.a. n.a. n.a. n.a. n.a. Database[TCMID]
NPO17270 Warionia saharae Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11697 Cirsium setosum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19689 Radix cirsii japonici Species Lymnaeidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5095 Digitalis ferruginea Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21263 Fructus kochiae n.a. n.a. n.a. n.a. n.a. n.a. Database[TCMID]
NPO22874 Bombyx mori Species Bombycidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23795 Herba seu radix cirsii japonici n.a. n.a. n.a. n.a. n.a. n.a. Database[TCMID]
NPO25890 Herba cirsii japonici n.a. n.a. n.a. n.a. n.a. n.a. Database[TCMID]
NPO29384.1 Glycyrrhiza glabra var. typica Varieties Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28276 Artemisia argyi Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12737.1 Torreya fargesii var. yunnanensis Varieties Taxaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15771 Polygonatum prattii Species Asparagaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17691 Santalum album Species Santalaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21346 Eriocaulon buergerianum Species Eriocaulaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO20096 Cirsium japonicum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO14039 Leucaena leucocephala Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO22245 Digitalis lanata Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17949 Gentiana thunbergii Species Gentianaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO29082 Persicaria hydropiper Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO2865 Abrus precatorius Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7176 Citrus sudachii Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8964 Herba lagotidis n.a. n.a. n.a. n.a. n.a. n.a. Database[TCMID]
NPO22657 Centaurea sp. Species n.a. n.a. n.a. n.a. n.a. Database[TCMID]
NPO17346 Salvia plebeia Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO27772 Flos inulae Species Lycaenidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8881 Centipeda minima Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11874 Ambrosia hispida Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21824 Lycopus lucidus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15289 Scoparia dulcis Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO1786 Pyrus pyrifolia Species Rosaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17106 Phyllanthus discoides Species Leiothrichidae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO20969 Pseudognaphalium affine Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO10051 Phyla nodiflora Species Verbenaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO228 Physostigma venenosum Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28508 Flourensia cernua Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5788 Millingtonia hortensis Species Bignoniaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17827 Scutellaria przewalskii Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO22769 Iva frutescens Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7527 Isodon leucophyllus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17464 Uncaria sessilifructus Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5788 Millingtonia hortensis Species Bignoniaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO14367 Hypericum hirsutum Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17106 Phyllanthus discoides Species Leiothrichidae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO2865 Abrus precatorius Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO228 Physostigma venenosum Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO20096 Cirsium japonicum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO23653 Nepeta hindostana Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO21824 Lycopus lucidus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO21346 Eriocaulon buergerianum Species Eriocaulaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO22874 Bombyx mori Species Bombycidae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO8881 Centipeda minima Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO8918 Plantago depressa Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17346 Salvia plebeia Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO28276 Artemisia argyi Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO26233 Helenium autumnale Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO31048 Papaver sommiferum Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO9295 Clerodendron fragrans n.a. n.a. n.a. n.a. n.a. n.a. Database[TCM_Taiwan]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17691 Santalum album Species Santalaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO15289 Scoparia dulcis Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO22245 Digitalis lanata Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO1278 Eriocaulon sieboldianum Species Eriocaulaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO21346 Eriocaulon buergerianum Species Eriocaulaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO11697 Cirsium setosum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO23706 Breea segeta n.a. n.a. n.a. n.a. n.a. n.a. Database[TM-MC]
NPO22245 Digitalis lanata Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO8918 Plantago depressa Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO20096 Cirsium japonicum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO17691 Santalum album Species Santalaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO18671 Saussurea involucrata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO21824 Lycopus lucidus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO8881 Centipeda minima Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO28276 Artemisia argyi Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO22170 Actinoplanes awajinensis Species Micromonosporaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO9498 Papaver somniferum Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6596 Vaccinium ashei Species Ericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25688 Mikania congesta Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11318 Eriodictyon californicum Species Namaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO759 Asphodelus tenuifolius Species Asphodelaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12737.1 Torreya fargesii var. yunnanensis Varieties Taxaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1399 Xylosma longifolia Species Salicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23653 Nepeta hindostana Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20868 Heterocentrotus mammillatus Species Echinometridae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2709 Flindersia dissosperma Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25551 Monodora grandiflora Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9497 Myrtopsis novae-caledoniae Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16065 Micromeria japonica Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO290 Gibberella lateritium n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO6987 Tolypothrix byssoidea Species Tolypothrichaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO25066 Werneria stuebelii Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26233 Helenium autumnale Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22769 Iva frutescens Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6098 Salvia officinalis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3342 Kniphofia pumila Species Xanthorrhoeaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12871 Arenaria kumaonensis Species Scolopacidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11798 Anthemis pseudocotula Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2286 Fischerella muscicola Species Hapalosiphonaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO17949 Gentiana thunbergii Species Gentianaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19430 Chondrococcus hornemanni n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO17462 Pouteria sapota Species Sapotaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15473 Ocotea heterochroma Species Lauraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5788 Millingtonia hortensis Species Bignoniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17270 Warionia saharae Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24959 Chaenomeles cathayensis Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18835 Aloe nobilis Species Asphodelaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17875 Erythroxylum microphyllum Species Erythroxylaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17640 Omphalotus nidiformis Species Omphalotaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8634 Podocarpus mannii Species Podocarpaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1958 Eupatorium leucolepis Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21346 Eriocaulon buergerianum Species Eriocaulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3676 Fusarium sambucinum Species Nectriaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9353 Solidago spathulata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8719 Fusarium vasinfectum Species Nectriaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23338 Cribrochalina dura Species Niphatidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17827 Scutellaria przewalskii Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO794 Lippia graveolens Species Verbenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10051 Phyla nodiflora Species Verbenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10826 Rabdosia weisiensis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19005 Engleromyces goetzei n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO19162 Tsuga heterophylla Species Pinaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16515 Siphonoglossa mexicana n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO11437 Alluaudia ascendens Species Didiereaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16763 Marrubium globosum Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14367 Hypericum hirsutum Species Hypericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20399 Turbinellus floccosus Species Gomphaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7527 Isodon leucophyllus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15971 Teclea boiviniana Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20096 Cirsium japonicum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1786 Pyrus pyrifolia Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10196 Echinocereus blanckii Species Cactaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8881 Centipeda minima Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8231 Jaspis digonoxea Species Ancorinidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7656 Pachyrhizus tuberosus Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17691 Santalum album Species Santalaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22245 Digitalis lanata Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11698 Drosera spatulata Species Droseraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25456 Cortinarius infractus Species Cortinariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15031 Senecio microglossus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20969 Pseudognaphalium affine Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17205 Laurencia thyrsifera Species Rhodomelaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4489 Achillea serbica Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19509 Euodia lunu-ankenda Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13706 Barleria acanthoides Species Acanthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7566 Ptelea viscosa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9599 Delphinium hybr Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12059 Triticum estivum Species Poaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22874 Bombyx mori Species Bombycidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11546 Ledebouria floribunda Species Hyacinthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24861 Usnea aciculifera Species Parmeliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17106 Phyllanthus discoides Species Leiothrichidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17346 Salvia plebeia Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22460 Vernonia pachyclada Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20640 Aloysia triphylla Species Verbenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18671 Saussurea involucrata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17105 Phaenocoma prolifera Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2865 Abrus precatorius Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23838 Kitasatospora kifunensis Species Streptomycetaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO18920 Hexalobus crispiflorus Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29082 Persicaria hydropiper Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8918 Plantago depressa Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21969 Veronicastrum virginicum Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2590 Cordia elaeagnoides Species Cordiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10889 Heterochordaria abietina n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO16738 Leptogorgia gilchristi Species Gorgoniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17155 Selaginella apoda Species Selaginellaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24451 Gaylussacia frondosa Species Ericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28508 Flourensia cernua Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17407 Bauhinia splendens Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11874 Ambrosia hispida Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19601 Albizia amara Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13470 Satureja odora Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14133 Eupatorium perfoliatum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13193 Procambarus clarkii Species Cambaridae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15819 Hunteria zeylanica Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7154 Glycyrrhiza uralensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14201 Riccia fluitans Species Ricciaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21518 Senecio tricephalus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6710 Sinapis nigra Species Brassicaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO669 Crepis pygmaea Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16352 Peperomia villipetiola Species Piperaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15289 Scoparia dulcis Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9405 Siphocampylus foliosus Species Campanulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17792 Penicillium lapidosum Species Aspergillaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12534 Gastrophysa cyanea Species Chrysomelidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO228 Physostigma venenosum Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4214 Centaurea collina Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14027 Dacryodes normandii Species Burseraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11697 Cirsium setosum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5445 Euonymus nanus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16484 Muraltia heisteria Species Polygalaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18445 Puccinia coronata Species Pucciniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11189 Anabaena sphaerica Species 0stocaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO24904 Mangifera gabonensis Species Anacardiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20756 Aspergillus unilateralis Species Aspergillaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6388 Mulguraea tridens Species Verbenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17620 Rhodopirellula baltica Species Planctomycetaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO17464 Uncaria sessilifructus Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28276 Artemisia argyi Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17829 Ibervillea sonorae Species Cucurbitaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25270 Trichoderma roseum Species Hypocreaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24761 Enicostema littorale Species Gentianaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14039 Leucaena leucocephala Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7635 Glycine max Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25579 Alstonia pneumatophora Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15771 Polygonatum prattii Species Asparagaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19268 Climacostomum virens Species Climacostomidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21824 Lycopus lucidus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17032 Knautia silvatica Species Caprifoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5095 Digitalis ferruginea Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14588 Baccharis trimera Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26459 Lissoclinum fragile Species Didemnidae Eukaryota n.a. n.a. n.a. Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  NP Quantity Composition/Concentration

Organism ID NP ID Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference
NPO20640 NPC241498 Dried Or Powder n.a. 29.13750001 n.a. n.a. mg/100g Database [PHENOL EXPLORER]
NPO794 NPC241498 Dried Or Powder n.a. 105.5944061 n.a. n.a. mg/100g Database [PHENOL EXPLORER]
NPO6098 NPC241498 Raw n.a. 16.29999924 n.a. n.a. mg/100g Database [PHENOL EXPLORER]
NPO41199 NPC241498 Raw n.a. 48.70000076 n.a. n.a. mg/100g Database [PHENOL EXPLORER]
NPO19472 NPC241498 Raw n.a. 20.79999924 n.a. n.a. mg/100g Database [PHENOL EXPLORER]
NPO42012 NPC241498 Raw n.a. 10.85000038 n.a. n.a. mg/100g Database [PHENOL EXPLORER]
NPO19472 NPC241498 n.a. n.a. 20.8 n.a. n.a. mg/100g of FW Database [Phenol-Explorer]
NPO41199 NPC241498 n.a. n.a. 48.7 n.a. n.a. mg/100g of FW Database [Phenol-Explorer]
NPO42012 NPC241498 n.a. n.a. 10.85 n.a. n.a. mg/100g of FW Database [Phenol-Explorer]
NPO42032 NPC241498 n.a. n.a. 29.1375 n.a. n.a. mg/100g of FW Database [Phenol-Explorer]

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT1315 Individual Protein Adenosine A1 receptor Rattus norvegicus pKi(uM) = -0.21 n.a. PMID[450928]
NPT1316 Individual Protein Adenosine A2a receptor Rattus norvegicus pKi(uM) = -0.88 n.a. PMID[450928]
NPT517 Cell Line Panel NCI-60 (60 carcinoma cell lines) Homo sapiens GI50 = 33000.0 nM PMID[450929]
NPT1315 Individual Protein Adenosine A1 receptor Rattus norvegicus Ki = 1610.0 nM PMID[450930]
NPT1316 Individual Protein Adenosine A2a receptor Rattus norvegicus Ki = 6480.0 nM PMID[450930]
NPT218 Individual Protein Adenosine A3 receptor Homo sapiens Displacement = 63.0 % PMID[450930]
NPT91 Cell Line KB Homo sapiens ED50 = 22.0 ug ml-1 PMID[450933]
NPT1512 Individual Protein Cell division protein kinase 5 Rattus norvegicus EC50 = 19100.0 nM PMID[450935]
NPT1851 Cell Line Col2 Homo sapiens ED50 > 20.0 ug ml-1 PMID[450937]
NPT453 Cell Line HT-1080 Homo sapiens ED50 = 5.2 ug ml-1 PMID[450937]
NPT91 Cell Line KB Homo sapiens ED50 = 5.6 ug ml-1 PMID[450937]
NPT1034 Cell Line Lu1 Homo sapiens ED50 = 17.6 ug ml-1 PMID[450937]
NPT147 Cell Line SK-MEL-2 Homo sapiens ED50 = 11.5 ug ml-1 PMID[450937]
NPT168 Cell Line P388 Mus musculus ED50 = 0.8 ug ml-1 PMID[450937]
NPT91 Cell Line KB Homo sapiens ED50 = 96.0 ug ml-1 PMID[450938]
NPT2049 Cell Line HT Homo sapiens ED50 = 10.1 ug ml-1 PMID[450939]
NPT1034 Cell Line Lu1 Homo sapiens ED50 > 20.0 ug ml-1 PMID[450939]
NPT1851 Cell Line Col2 Homo sapiens ED50 > 20.0 ug ml-1 PMID[450939]
NPT91 Cell Line KB Homo sapiens ED50 = 18.8 ug ml-1 PMID[450939]
NPT762 Cell Line A-431 Homo sapiens ED50 = 1.2 ug ml-1 PMID[450939]
NPT858 Cell Line LNCaP Homo sapiens ED50 = 7.1 ug ml-1 PMID[450939]
NPT133 Cell Line ZR-75-1 Homo sapiens ED50 = 1.2 ug ml-1 PMID[450939]
NPT493 Individual Protein Neuraminidase Influenza A virus IC50 = 46300.0 nM PMID[450940]
NPT493 Individual Protein Neuraminidase Influenza A virus IC50 = 26000.0 nM PMID[450940]
NPT493 Individual Protein Neuraminidase Influenza A virus IC50 = 33200.0 nM PMID[450940]
NPT616 Cell Line MDCK Canis lupus familiaris CC50 = 172460.0 nM PMID[450940]
NPT616 Cell Line MDCK Canis lupus familiaris MNCC = 24.7 uM PMID[450940]
NPT65 Cell Line HepG2 Homo sapiens Inhibition = 6.0 % PMID[450941]
NPT1602 Individual Protein Neuraminidase Influenza A virus (A/Puerto Rico/8/1934(H1N1)) IC50 = 13.9 ug.mL-1 PMID[450942]
NPT1602 Individual Protein Neuraminidase Influenza A virus (A/Puerto Rico/8/1934(H1N1)) logIC50 = 1.143 n.a. PMID[450942]
NPT537 Individual Protein Ras-related protein Rab-9A Homo sapiens Potency = 3162.3 nM PMID[450943]
NPT50 Individual Protein Tyrosyl-DNA phosphodiesterase 1 Homo sapiens Potency = 22387.2 nM PMID[450943]
NPT50 Individual Protein Tyrosyl-DNA phosphodiesterase 1 Homo sapiens Potency = 70794.6 nM PMID[450944]
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 19952.6 nM PMID[450943]
NPT531 Individual Protein Nuclear receptor ROR-gamma Mus musculus Potency = 35481.3 nM PMID[450943]
NPT54 Individual Protein Nonstructural protein 1 Influenza A virus Potency = 11220.2 nM PMID[450943]
NPT538 Individual Protein Niemann-Pick C1 protein Homo sapiens Potency = 4466.8 nM PMID[450943]
NPT524 Individual Protein Serine-protein kinase ATM Homo sapiens Potency = 25118.9 nM PMID[450943]
NPT531 Individual Protein Nuclear receptor ROR-gamma Mus musculus Potency = 35481.3 nM PMID[450944]
NPT59 Individual Protein DNA polymerase beta Homo sapiens Potency = 89125.1 nM PMID[450943]
NPT61 Individual Protein Beta-glucocerebrosidase Homo sapiens Potency n.a. 25118.9 nM PMID[450943]
NPT2629 Individual Protein FAD-linked sulfhydryl oxidase ALR Homo sapiens AC50 = 572.0 nM PMID[450943]
NPT539 Individual Protein Cellular tumor antigen p53 Homo sapiens Potency n.a. 39810.7 nM PMID[450943]
NPT64 Individual Protein ATPase family AAA domain-containing protein 5 Homo sapiens Potency n.a. 9196.2 nM PMID[450943]
NPT64 Individual Protein ATPase family AAA domain-containing protein 5 Homo sapiens Potency n.a. 5802.4 nM PMID[450943]
NPT199 Individual Protein DNA polymerase kappa Homo sapiens Potency n.a. 33587.5 nM PMID[450944]
NPT484 Individual Protein Luciferin 4-monooxygenase Photinus pyralis Potency n.a. 849.2 nM PMID[450943]
NPT367 Cell Line MDA-N Homo sapiens GI50 n.a. 37153.52 nM PMID[450945]
NPT368 Cell Line SN12C Homo sapiens GI50 n.a. 39355.01 nM PMID[450945]
NPT369 Cell Line ACHN Homo sapiens GI50 n.a. 26791.68 nM PMID[450945]
NPT370 Cell Line NCI-H23 Homo sapiens GI50 n.a. 42169.65 nM PMID[450945]
NPT371 Cell Line UO-31 Homo sapiens GI50 n.a. 25118.86 nM PMID[450945]
NPT116 Cell Line HL-60 Homo sapiens GI50 n.a. 24490.63 nM PMID[450945]
NPT372 Cell Line HOP-92 Homo sapiens GI50 n.a. 2910.72 nM PMID[450945]
NPT90 Cell Line DU-145 Homo sapiens GI50 n.a. 30478.95 nM PMID[450945]
NPT374 Cell Line SF-539 Homo sapiens GI50 n.a. 26977.39 nM PMID[450945]
NPT373 Cell Line SK-MEL-5 Homo sapiens GI50 n.a. 15523.87 nM PMID[450945]
NPT375 Cell Line Malme-3M Homo sapiens GI50 n.a. 74816.95 nM PMID[450945]
NPT111 Cell Line K562 Homo sapiens GI50 n.a. 34753.62 nM PMID[450945]
NPT376 Cell Line A498 Homo sapiens GI50 n.a. 2570.4 nM PMID[450945]
NPT377 Cell Line OVCAR-3 Homo sapiens GI50 n.a. 44055.49 nM PMID[450945]
NPT112 Cell Line MOLT-4 Homo sapiens GI50 n.a. 25351.29 nM PMID[450945]
NPT379 Cell Line HOP-62 Homo sapiens GI50 n.a. 46665.94 nM PMID[450945]
NPT378 Cell Line NCI/ADR-RES Homo sapiens GI50 n.a. 36140.99 nM PMID[450945]
NPT380 Cell Line U-251 Homo sapiens GI50 n.a. 42657.95 nM PMID[450945]
NPT382 Cell Line OVCAR-5 Homo sapiens GI50 n.a. 75162.29 nM PMID[450945]
NPT383 Cell Line SNB-19 Homo sapiens GI50 n.a. 56104.8 nM PMID[450945]
NPT82 Cell Line MDA-MB-231 Homo sapiens GI50 n.a. 74473.2 nM PMID[450945]
NPT385 Cell Line SR Homo sapiens GI50 n.a. 27925.44 nM PMID[450945]
NPT384 Cell Line TK-10 Homo sapiens GI50 n.a. 39174.19 nM PMID[450945]
NPT323 Cell Line SW-620 Homo sapiens GI50 n.a. 34119.29 nM PMID[450945]
NPT455 Cell Line NCI-H522 Homo sapiens GI50 n.a. 36224.3 nM PMID[450945]
NPT386 Cell Line KM12 Homo sapiens GI50 n.a. 31477.48 nM PMID[450945]
NPT387 Cell Line M14 Homo sapiens GI50 n.a. 38636.7 nM PMID[450945]
NPT388 Cell Line NCI-H322M Homo sapiens GI50 n.a. 49090.79 nM PMID[450945]
NPT389 Cell Line RPMI-8226 Homo sapiens GI50 n.a. 46344.69 nM PMID[450945]
NPT456 Cell Line OVCAR-4 Homo sapiens GI50 n.a. 35809.64 nM PMID[450945]
NPT390 Cell Line LOX IMVI Homo sapiens GI50 n.a. 39174.19 nM PMID[450945]
NPT457 Cell Line BT-549 Homo sapiens GI50 n.a. 28313.92 nM PMID[450945]
NPT147 Cell Line SK-MEL-2 Homo sapiens GI50 n.a. 27164.39 nM PMID[450945]
NPT391 Cell Line HCC 2998 Homo sapiens GI50 n.a. 28707.81 nM PMID[450945]
NPT81 Cell Line A549 Homo sapiens GI50 n.a. 35481.34 nM PMID[450945]
NPT392 Cell Line SNB-75 Homo sapiens GI50 n.a. 17298.16 nM PMID[450945]
NPT393 Cell Line HCT-116 Homo sapiens GI50 n.a. 35318.32 nM PMID[450945]
NPT148 Cell Line HCT-15 Homo sapiens GI50 n.a. 38725.76 nM PMID[450945]
NPT394 Cell Line EKVX Homo sapiens GI50 n.a. 8072.35 nM PMID[450945]
NPT395 Cell Line SF-268 Homo sapiens GI50 n.a. 46558.61 nM PMID[450945]
NPT306 Cell Line PC-3 Homo sapiens GI50 n.a. 34197.94 nM PMID[450945]
NPT83 Cell Line MCF7 Homo sapiens GI50 n.a. 51999.6 nM PMID[450945]
NPT146 Cell Line SK-OV-3 Homo sapiens GI50 n.a. 48194.78 nM PMID[450945]
NPT396 Cell Line T47D Homo sapiens GI50 n.a. 33419.5 nM PMID[450945]
NPT397 Cell Line NCI-H460 Homo sapiens GI50 n.a. 30760.97 nM PMID[450945]
NPT398 Cell Line UACC-62 Homo sapiens GI50 n.a. 18967.06 nM PMID[450945]
NPT400 Cell Line MDA-MB-435 Homo sapiens GI50 n.a. 36307.81 nM PMID[450945]
NPT399 Cell Line SF-295 Homo sapiens GI50 n.a. 44055.49 nM PMID[450945]
NPT458 Cell Line IGROV-1 Homo sapiens GI50 n.a. 22698.65 nM PMID[450945]
NPT402 Cell Line Hs-578T Homo sapiens GI50 n.a. 18923.44 nM PMID[450945]
NPT401 Cell Line 786-0 Homo sapiens GI50 n.a. 60117.37 nM PMID[450945]
NPT403 Cell Line UACC-257 Homo sapiens GI50 n.a. 100000.0 nM PMID[450945]
NPT404 Cell Line CCRF-CEM Homo sapiens GI50 n.a. 20606.3 nM PMID[450945]
NPT139 Cell Line HT-29 Homo sapiens GI50 n.a. 45708.82 nM PMID[450945]
NPT405 Cell Line NCI-H226 Homo sapiens GI50 n.a. 77624.71 nM PMID[450945]
NPT170 Cell Line SK-MEL-28 Homo sapiens GI50 n.a. 45708.82 nM PMID[450945]
NPT407 Cell Line COLO 205 Homo sapiens GI50 n.a. 90364.95 nM PMID[450945]
NPT406 Cell Line RXF 393 Homo sapiens GI50 n.a. 51522.86 nM PMID[450945]
NPT1380 Individual Protein Avian myoblastosis virus polyprotein II Avian myeloblastosis virus Inhibition = 23.3 % PMID[450947]
NPT50 Individual Protein Tyrosyl-DNA phosphodiesterase 1 Homo sapiens Potency n.a. 29092.9 nM PMID[450943]
NPT585 Individual Protein Nuclear receptor subfamily 0 group B member 1 Homo sapiens IC50 > 833.72 nM PMID[450943]
NPT444 Individual Protein Ubiquitin carboxyl-terminal hydrolase 1 Homo sapiens Potency n.a. 6309.6 nM PMID[450943]
NPT535 Individual Protein Parathyroid hormone receptor Homo sapiens Potency n.a. 7079.5 nM PMID[450943]
NPT49 Individual Protein DNA-(apurinic or apyrimidinic site) lyase Homo sapiens Potency n.a. 19952.6 nM PMID[450944]
NPT1618 Individual Protein Peroxisome proliferator-activated receptor gamma Mus musculus Emax = 11.3 n.a. PMID[450949]
NPT1618 Individual Protein Peroxisome proliferator-activated receptor gamma Mus musculus EC50 = 7300.0 nM PMID[450949]
NPT1265 Individual Protein Serine/threonine-protein kinase PIM1 Homo sapiens IC50 = 2710.0 nM PMID[450951]
NPT4184 Individual Protein Dipeptidyl peptidase IV Sus scrofa IC50 = 490.0 nM PMID[450953]
NPT1603 Individual Protein Cytochrome P450 1A1 Homo sapiens Inhibition = 86.0 % PMID[450954]
NPT1265 Individual Protein Serine/threonine-protein kinase PIM1 Homo sapiens IC50 = 2710.0 nM PMID[450955]
NPT3213 Individual Protein MAP kinase signal-integrating kinase 2 Homo sapiens Inhibition = 93.0 % PMID[450958]
NPT3213 Individual Protein MAP kinase signal-integrating kinase 2 Homo sapiens IC50 = 252.0 nM PMID[450958]
NPT3283 Individual Protein MAP kinase-interacting serine/threonine-protein kinase MNK1 Homo sapiens Inhibition > 70.0 % PMID[450958]
NPT3283 Individual Protein MAP kinase-interacting serine/threonine-protein kinase MNK1 Homo sapiens IC50 = 1205.0 nM PMID[450958]
NPT6530 Cell Line MOLM-13 Homo sapiens IC50 = 6400.0 nM PMID[450958]
NPT1649 Cell Line MV4-11 Homo sapiens IC50 = 8200.0 nM PMID[450958]
NPT996 Protein Complex GABA-A receptor; anion channel Homo sapiens Ki = 1000.0 nM PMID[450927]
NPT2 Others Unspecified logKi = 0.0 n.a. PMID[450931]
NPT2 Others Unspecified Inhibition = -92.0 % PMID[450932]
NPT2 Others Unspecified Inhibition = -75.0 % PMID[450932]
NPT2 Others Unspecified Inhibition = -18.0 % PMID[450932]
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 125.0 ug.mL-1 PMID[450936]
NPT79 Organism Bacillus subtilis Bacillus subtilis MBC > 250.0 ug ml-1 PMID[450936]
NPT766 Organism Proteus vulgaris Proteus vulgaris MIC = 125.0 ug.mL-1 PMID[450936]
NPT766 Organism Proteus vulgaris Proteus vulgaris MBC > 250.0 ug ml-1 PMID[450936]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 = 19.0 ug ml-1 PMID[450937]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 = 2.8 ug ml-1 PMID[450937]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 > 20.0 ug ml-1 PMID[450939]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 = 1.3 ug ml-1 PMID[450939]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 = 8.7 ug ml-1 PMID[450939]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 = 8.8 ug ml-1 PMID[450939]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. ED50 = 14.6 ug ml-1 PMID[450939]
NPT742 Organism Influenza A virus Influenza A virus IC50 = 24700.0 nM PMID[450940]
NPT2 Others Unspecified Ratio CC50/IC50 = 6.98 n.a. PMID[450940]
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Inhibition = 0.0 % PMID[450941]
NPT2 Others Unspecified IFI = 1.49 % PMID[450941]
NPT6 Organism Plasmodium falciparum Plasmodium falciparum XC50 = 770.96 nM PMID[450941]
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Inhibition = 96.0 % PMID[450941]
NPT536 Uncleic Acid microRNA 21 Homo sapiens Potency = 2328.1 nM PMID[450943]
NPT197 Protein-Protein Interaction Menin/Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 31622.8 nM PMID[450944]
NPT2 Others Unspecified Potency n.a. 35481.3 nM PMID[450943]
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency n.a. 329.4 nM PMID[450943]
NPT2 Others Unspecified Potency n.a. 28183.8 nM PMID[450943]
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency n.a. 2616.9 nM PMID[450943]
NPT191 Organism Hepatitis C virus Hepatitis C virus EC50 = 36300.0 nM PMID[450946]
NPT27 Others Unspecified CC50 > 50000.0 nM PMID[450946]
NPT790 Organism Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC = 100.0 ug.mL-1 PMID[450948]
NPT790 Organism Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv logMIC = 4.605 n.a. PMID[450948]
NPT35 Others n.a. IC50 > 67536.0 nM PMID[450943]
NPT2 Others Unspecified Potency n.a. 11220.2 nM PMID[450944]
NPT2 Others Unspecified IC50 = 13700.0 nM PMID[450949]
NPT942 Individual Protein Glucose transporter Homo sapiens Inhibition = 1.18 % PMID[450950]
NPT943 Individual Protein Hexose transporter 1 Plasmodium falciparum Inhibition = 1.7 % PMID[450950]
NPT944 Individual Protein Glucose transporter Leishmania mexicana Inhibition = 3.31 % PMID[450950]
NPT2 Others Unspecified Potency n.a. 707.9 nM PMID[450943]
NPT2535 Tissue Plasma Oryctolagus cuniculus PT = 6.25 s PMID[450952]
NPT2535 Tissue Plasma Oryctolagus cuniculus TT = 25.96 s PMID[450952]
NPT2535 Tissue Plasma Oryctolagus cuniculus APTT = 33.1 s PMID[450952]
NPT2535 Tissue Plasma Oryctolagus cuniculus Activity = 5.38 g/L PMID[450952]
NPT35 Others n.a. IC50 = 23670.0 nM PMID[450952]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Inhibition = 88.05 % PMID[450952]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. Inhibition = 62.39 % PMID[450952]
NPT35 Others n.a. Solubility = 4.27 ug.mL-1 PMID[450952]
NPT35 Others n.a. LogP = 1.765 n.a. PMID[450952]
NPT35 Others n.a. LogP = 1.681 n.a. PMID[450952]
NPT35 Others n.a. LogP = 1.018 n.a. PMID[450952]
NPT20556 SINGLE PROTEIN Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus 2 Inhibition = 0.94 % PMID[450956]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Inhibition = -0.09 % PMID[450957]
NPT22245 PROTEIN FAMILY MAP kinase-interacting serine/threonine-protein kinase 1/2 Homo sapiens Inhibition = 100.0 % PMID[450958]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

  Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC241498 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC71334
1.0 High Similarity NPC83508
1.0 High Similarity NPC120163
1.0 High Similarity NPC222830
1.0 High Similarity NPC188203
1.0 High Similarity NPC57030
1.0 High Similarity NPC256283
1.0 High Similarity NPC100887
1.0 High Similarity NPC156222
1.0 High Similarity NPC275722
1.0 High Similarity NPC275836
1.0 High Similarity NPC187498
1.0 High Similarity NPC212678
1.0 High Similarity NPC162313
1.0 High Similarity NPC239128
1.0 High Similarity NPC293183
1.0 High Similarity NPC131624
1.0 High Similarity NPC25270
1.0 High Similarity NPC198826
1.0 High Similarity NPC301323
0.9932 High Similarity NPC255350
0.9932 High Similarity NPC176775
0.9932 High Similarity NPC274327
0.9932 High Similarity NPC231018
0.9932 High Similarity NPC183878
0.9932 High Similarity NPC69394
0.9932 High Similarity NPC160951
0.9932 High Similarity NPC47781
0.9932 High Similarity NPC145379
0.9932 High Similarity NPC22519
0.9864 High Similarity NPC146165
0.9864 High Similarity NPC227325
0.9864 High Similarity NPC163780
0.9864 High Similarity NPC201136
0.9864 High Similarity NPC167815
0.9864 High Similarity NPC128863
0.9864 High Similarity NPC44079
0.9864 High Similarity NPC256612
0.9864 High Similarity NPC213622
0.9864 High Similarity NPC2476
0.9864 High Similarity NPC280339
0.9864 High Similarity NPC201451
0.9864 High Similarity NPC4455
0.9864 High Similarity NPC26227
0.9864 High Similarity NPC138360
0.9864 High Similarity NPC92659
0.9864 High Similarity NPC50715
0.9864 High Similarity NPC20830
0.9864 High Similarity NPC183597
0.9864 High Similarity NPC196439
0.9863 High Similarity NPC142540
0.9862 High Similarity NPC306821
0.9862 High Similarity NPC184136
0.9797 High Similarity NPC266960
0.9797 High Similarity NPC43243
0.9797 High Similarity NPC98661
0.9797 High Similarity NPC247017
0.9797 High Similarity NPC245546
0.9797 High Similarity NPC49824
0.9796 High Similarity NPC250822
0.9796 High Similarity NPC75279
0.9796 High Similarity NPC276409
0.9795 High Similarity NPC226973
0.9795 High Similarity NPC208043
0.9793 High Similarity NPC287101
0.9793 High Similarity NPC296197
0.9793 High Similarity NPC17286
0.9793 High Similarity NPC183950
0.9793 High Similarity NPC223579
0.9793 High Similarity NPC52005
0.9793 High Similarity NPC137062
0.9793 High Similarity NPC216318
0.9793 High Similarity NPC259713
0.9732 High Similarity NPC305663
0.9732 High Similarity NPC287979
0.9732 High Similarity NPC470402
0.9732 High Similarity NPC75215
0.9732 High Similarity NPC203891
0.9732 High Similarity NPC227192
0.9732 High Similarity NPC176665
0.9732 High Similarity NPC224137
0.9732 High Similarity NPC163524
0.9732 High Similarity NPC101830
0.9732 High Similarity NPC93376
0.9732 High Similarity NPC189179
0.9732 High Similarity NPC110070
0.973 High Similarity NPC208197
0.973 High Similarity NPC2928
0.9728 High Similarity NPC39732
0.9728 High Similarity NPC180234
0.9728 High Similarity NPC120537
0.9728 High Similarity NPC301123
0.9728 High Similarity NPC199100
0.9728 High Similarity NPC60972
0.9726 High Similarity NPC45873
0.9724 High Similarity NPC120464
0.9667 High Similarity NPC143828
0.9667 High Similarity NPC300943
0.9667 High Similarity NPC4481
0.9667 High Similarity NPC152166
0.9667 High Similarity NPC204854
0.9667 High Similarity NPC22472
0.9667 High Similarity NPC191459
0.9667 High Similarity NPC19687
0.9667 High Similarity NPC7846
0.9667 High Similarity NPC288669
0.9667 High Similarity NPC105242
0.9667 High Similarity NPC176300
0.9667 High Similarity NPC253634
0.9667 High Similarity NPC25495
0.9667 High Similarity NPC18772
0.9667 High Similarity NPC115798
0.9667 High Similarity NPC9609
0.9667 High Similarity NPC18607
0.9667 High Similarity NPC261004
0.9667 High Similarity NPC130894
0.9664 High Similarity NPC472916
0.9664 High Similarity NPC255106
0.9664 High Similarity NPC474520
0.9664 High Similarity NPC235165
0.9664 High Similarity NPC292107
0.9662 High Similarity NPC206238
0.9662 High Similarity NPC271779
0.9662 High Similarity NPC88645
0.9662 High Similarity NPC292214
0.9662 High Similarity NPC86485
0.9662 High Similarity NPC167091
0.966 High Similarity NPC200740
0.966 High Similarity NPC54394
0.966 High Similarity NPC225731
0.966 High Similarity NPC117579
0.966 High Similarity NPC252933
0.966 High Similarity NPC125062
0.966 High Similarity NPC308451
0.9658 High Similarity NPC328119
0.9658 High Similarity NPC48479
0.9658 High Similarity NPC177298
0.9655 High Similarity NPC61871
0.9655 High Similarity NPC108406
0.9655 High Similarity NPC239312
0.9655 High Similarity NPC130230
0.9655 High Similarity NPC275772
0.9655 High Similarity NPC30647
0.9655 High Similarity NPC55557
0.9655 High Similarity NPC12200
0.9603 High Similarity NPC476980
0.96 High Similarity NPC472911
0.96 High Similarity NPC78302
0.96 High Similarity NPC48208
0.96 High Similarity NPC245758
0.96 High Similarity NPC156057
0.96 High Similarity NPC210084
0.96 High Similarity NPC7973
0.96 High Similarity NPC78225
0.96 High Similarity NPC472914
0.96 High Similarity NPC29841
0.96 High Similarity NPC99597
0.96 High Similarity NPC475267
0.96 High Similarity NPC472910
0.96 High Similarity NPC235215
0.96 High Similarity NPC162869
0.96 High Similarity NPC472913
0.96 High Similarity NPC472438
0.96 High Similarity NPC474208
0.96 High Similarity NPC474836
0.96 High Similarity NPC222814
0.96 High Similarity NPC96167
0.9597 High Similarity NPC32557
0.9597 High Similarity NPC189960
0.9597 High Similarity NPC214138
0.9595 High Similarity NPC209487
0.9595 High Similarity NPC269451
0.9595 High Similarity NPC245382
0.9595 High Similarity NPC55205
0.9595 High Similarity NPC39007
0.9595 High Similarity NPC27208
0.9595 High Similarity NPC131266
0.9595 High Similarity NPC100971
0.9595 High Similarity NPC35763
0.9595 High Similarity NPC216769
0.9595 High Similarity NPC181209
0.9595 High Similarity NPC121522
0.9595 High Similarity NPC82325
0.9595 High Similarity NPC161277
0.9595 High Similarity NPC100263
0.9595 High Similarity NPC101996
0.9595 High Similarity NPC291802
0.9595 High Similarity NPC279989
0.9592 High Similarity NPC61620
0.9592 High Similarity NPC62042
0.9589 High Similarity NPC195202
0.9589 High Similarity NPC118726
0.9589 High Similarity NPC12367
0.9539 High Similarity NPC258331
0.9536 High Similarity NPC193842
0.9533 High Similarity NPC191146
0.9533 High Similarity NPC100916
0.9533 High Similarity NPC55619
0.9533 High Similarity NPC200388
0.9533 High Similarity NPC268161

  Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC241498 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9932 High Similarity NPD2801 Approved
0.9463 High Similarity NPD1934 Approved
0.9448 High Similarity NPD1511 Approved
0.932 High Similarity NPD1512 Approved
0.915 High Similarity NPD3882 Suspended
0.9145 High Similarity NPD2393 Clinical (unspecified phase)
0.8961 High Similarity NPD3817 Phase 2
0.8875 High Similarity NPD3818 Discontinued
0.8868 High Similarity NPD6168 Clinical (unspecified phase)
0.8868 High Similarity NPD6167 Clinical (unspecified phase)
0.8868 High Similarity NPD6166 Phase 2
0.8834 High Similarity NPD4338 Clinical (unspecified phase)
0.882 High Similarity NPD7054 Approved
0.8765 High Similarity NPD7472 Approved
0.8742 High Similarity NPD4378 Clinical (unspecified phase)
0.865 High Similarity NPD7074 Phase 3
0.8616 High Similarity NPD5494 Approved
0.8598 High Similarity NPD6797 Phase 2
0.8545 High Similarity NPD7251 Discontinued
0.8544 High Similarity NPD4868 Clinical (unspecified phase)
0.8523 High Similarity NPD1552 Clinical (unspecified phase)
0.8523 High Similarity NPD1550 Clinical (unspecified phase)
0.8514 High Similarity NPD1510 Phase 2
0.8494 Intermediate Similarity NPD7808 Phase 3
0.8467 Intermediate Similarity NPD1549 Phase 2
0.8462 Intermediate Similarity NPD4380 Phase 2
0.8395 Intermediate Similarity NPD6232 Discontinued
0.8375 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.8367 Intermediate Similarity NPD943 Approved
0.8367 Intermediate Similarity NPD1240 Approved
0.8365 Intermediate Similarity NPD5402 Approved
0.8354 Intermediate Similarity NPD7473 Discontinued
0.8333 Intermediate Similarity NPD1247 Approved
0.8333 Intermediate Similarity NPD2796 Approved
0.8312 Intermediate Similarity NPD6799 Approved
0.8302 Intermediate Similarity NPD1465 Phase 2
0.8261 Intermediate Similarity NPD7075 Discontinued
0.8258 Intermediate Similarity NPD7410 Clinical (unspecified phase)
0.8255 Intermediate Similarity NPD1607 Approved
0.8224 Intermediate Similarity NPD970 Clinical (unspecified phase)
0.8187 Intermediate Similarity NPD7096 Clinical (unspecified phase)
0.8144 Intermediate Similarity NPD5844 Phase 1
0.8125 Intermediate Similarity NPD6801 Discontinued
0.8095 Intermediate Similarity NPD1529 Clinical (unspecified phase)
0.8075 Intermediate Similarity NPD7819 Suspended
0.8067 Intermediate Similarity NPD230 Phase 1
0.8067 Intermediate Similarity NPD447 Suspended
0.8047 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.8036 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.8027 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.8025 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.8012 Intermediate Similarity NPD3926 Phase 2
0.8 Intermediate Similarity NPD6599 Discontinued
0.8 Intermediate Similarity NPD1612 Clinical (unspecified phase)
0.8 Intermediate Similarity NPD3750 Approved
0.8 Intermediate Similarity NPD1613 Approved
0.7988 Intermediate Similarity NPD919 Approved
0.7974 Intermediate Similarity NPD2935 Discontinued
0.795 Intermediate Similarity NPD7411 Suspended
0.7935 Intermediate Similarity NPD2800 Approved
0.7925 Intermediate Similarity NPD5403 Approved
0.7911 Intermediate Similarity NPD5401 Approved
0.7908 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.7892 Intermediate Similarity NPD6959 Discontinued
0.7857 Intermediate Similarity NPD1551 Phase 2
0.7818 Intermediate Similarity NPD3749 Approved
0.7812 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.78 Intermediate Similarity NPD3027 Phase 3
0.7791 Intermediate Similarity NPD6559 Discontinued
0.7785 Intermediate Similarity NPD9494 Approved
0.7771 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.7764 Intermediate Similarity NPD1653 Approved
0.7748 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.7712 Intermediate Similarity NPD1933 Approved
0.7702 Intermediate Similarity NPD920 Approved
0.7692 Intermediate Similarity NPD2344 Approved
0.7688 Intermediate Similarity NPD2534 Approved
0.7688 Intermediate Similarity NPD2532 Approved
0.7688 Intermediate Similarity NPD2533 Approved
0.7684 Intermediate Similarity NPD8397 Clinical (unspecified phase)
0.7677 Intermediate Similarity NPD3748 Approved
0.7661 Intermediate Similarity NPD3751 Discontinued
0.7651 Intermediate Similarity NPD7768 Phase 2
0.7647 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.7635 Intermediate Similarity NPD4379 Clinical (unspecified phase)
0.7632 Intermediate Similarity NPD2313 Discontinued
0.7625 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.761 Intermediate Similarity NPD6190 Approved
0.7607 Intermediate Similarity NPD3226 Approved
0.7595 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7595 Intermediate Similarity NPD1243 Approved
0.7578 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.7574 Intermediate Similarity NPD7199 Phase 2
0.7564 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.756 Intermediate Similarity NPD6234 Discontinued
0.7547 Intermediate Similarity NPD4628 Phase 3
0.7533 Intermediate Similarity NPD1203 Approved
0.7529 Intermediate Similarity NPD3787 Discontinued
0.7516 Intermediate Similarity NPD6099 Approved
0.7516 Intermediate Similarity NPD6100 Approved
0.75 Intermediate Similarity NPD2309 Approved
0.75 Intermediate Similarity NPD7501 Clinical (unspecified phase)
0.7485 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7468 Intermediate Similarity NPD2346 Discontinued
0.7466 Intermediate Similarity NPD1548 Phase 1
0.7453 Intermediate Similarity NPD643 Clinical (unspecified phase)
0.7452 Intermediate Similarity NPD2799 Discontinued
0.745 Intermediate Similarity NPD9269 Phase 2
0.7443 Intermediate Similarity NPD4419 Clinical (unspecified phase)
0.7436 Intermediate Similarity NPD6651 Approved
0.7429 Intermediate Similarity NPD5953 Discontinued
0.7416 Intermediate Similarity NPD8055 Clinical (unspecified phase)
0.7414 Intermediate Similarity NPD7286 Phase 2
0.7403 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7386 Intermediate Similarity NPD7685 Pre-registration
0.7383 Intermediate Similarity NPD422 Phase 1
0.7372 Intermediate Similarity NPD1899 Clinical (unspecified phase)
0.7365 Intermediate Similarity NPD6844 Discontinued
0.7365 Intermediate Similarity NPD37 Approved
0.7337 Intermediate Similarity NPD4965 Approved
0.7337 Intermediate Similarity NPD4967 Phase 2
0.7337 Intermediate Similarity NPD4966 Approved
0.7333 Intermediate Similarity NPD9717 Approved
0.7301 Intermediate Similarity NPD7390 Discontinued
0.729 Intermediate Similarity NPD3268 Approved
0.7283 Intermediate Similarity NPD5242 Approved
0.7273 Intermediate Similarity NPD6832 Phase 2
0.7273 Intermediate Similarity NPD4908 Phase 1
0.7267 Intermediate Similarity NPD1610 Phase 2
0.7267 Intermediate Similarity NPD1547 Clinical (unspecified phase)
0.7257 Intermediate Similarity NPD7228 Approved
0.7255 Intermediate Similarity NPD2798 Approved
0.7244 Intermediate Similarity NPD6233 Phase 2
0.7237 Intermediate Similarity NPD3225 Approved
0.7233 Intermediate Similarity NPD7033 Discontinued
0.7233 Intermediate Similarity NPD4308 Phase 3
0.7222 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.7219 Intermediate Similarity NPD1608 Approved
0.7208 Intermediate Similarity NPD3018 Phase 2
0.7202 Intermediate Similarity NPD6385 Approved
0.7202 Intermediate Similarity NPD6386 Approved
0.7195 Intermediate Similarity NPD4357 Discontinued
0.719 Intermediate Similarity NPD2797 Approved
0.7182 Intermediate Similarity NPD8434 Phase 2
0.7181 Intermediate Similarity NPD9268 Approved
0.7179 Intermediate Similarity NPD4907 Clinical (unspecified phase)
0.7179 Intermediate Similarity NPD411 Approved
0.7176 Intermediate Similarity NPD5353 Approved
0.7162 Intermediate Similarity NPD5536 Phase 2
0.716 Intermediate Similarity NPD2654 Approved
0.7152 Intermediate Similarity NPD7422 Clinical (unspecified phase)
0.7151 Intermediate Similarity NPD8090 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD2403 Approved
0.7135 Intermediate Similarity NPD4363 Phase 3
0.7135 Intermediate Similarity NPD4360 Phase 2
0.7128 Intermediate Similarity NPD6778 Approved
0.7128 Intermediate Similarity NPD6780 Approved
0.7128 Intermediate Similarity NPD6776 Approved
0.7128 Intermediate Similarity NPD6782 Approved
0.7128 Intermediate Similarity NPD6781 Approved
0.7128 Intermediate Similarity NPD6777 Approved
0.7128 Intermediate Similarity NPD6779 Approved
0.7126 Intermediate Similarity NPD5710 Approved
0.7126 Intermediate Similarity NPD5711 Approved
0.7111 Intermediate Similarity NPD8313 Approved
0.7111 Intermediate Similarity NPD8312 Approved
0.7108 Intermediate Similarity NPD1940 Clinical (unspecified phase)
0.7105 Intermediate Similarity NPD1481 Phase 2
0.7103 Intermediate Similarity NPD228 Approved
0.7097 Intermediate Similarity NPD2861 Phase 2
0.7078 Intermediate Similarity NPD3266 Approved
0.7078 Intermediate Similarity NPD1470 Approved
0.7078 Intermediate Similarity NPD3267 Approved
0.7076 Intermediate Similarity NPD4288 Approved
0.707 Intermediate Similarity NPD6798 Discontinued
0.7059 Intermediate Similarity NPD2982 Phase 2
0.7059 Intermediate Similarity NPD2983 Phase 2
0.7056 Intermediate Similarity NPD7549 Discontinued
0.7055 Intermediate Similarity NPD1652 Phase 2
0.7048 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7039 Intermediate Similarity NPD1535 Discovery
0.7039 Intermediate Similarity NPD1201 Approved
0.7035 Intermediate Similarity NPD2899 Discontinued
0.7029 Intermediate Similarity NPD7229 Phase 3
0.702 Intermediate Similarity NPD17 Approved
0.7016 Intermediate Similarity NPD7435 Discontinued
0.7006 Intermediate Similarity NPD4625 Phase 3
0.7005 Intermediate Similarity NPD4362 Clinical (unspecified phase)
0.7005 Intermediate Similarity NPD4361 Phase 2
0.7 Intermediate Similarity NPD7615 Clinical (unspecified phase)
0.7 Intermediate Similarity NPD9545 Approved
0.6995 Remote Similarity NPD7584 Approved
0.6995 Remote Similarity NPD8150 Discontinued
0.6993 Remote Similarity NPD2981 Phase 2
0.6981 Remote Similarity NPD1558 Phase 1
0.6981 Remote Similarity NPD4307 Phase 2
0.698 Remote Similarity NPD9493 Approved
0.6977 Remote Similarity NPD2296 Approved
0.697 Remote Similarity NPD2354 Approved
0.6962 Remote Similarity NPD1296 Phase 2

  Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity
B: biological targets similarity
C: networks similarity
D: cell-based bioactivity similarity
E: similarity based on clinical data